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Items: 1 to 20 of 32


Using SHAPE-MaP to probe small molecule-RNA interactions.

Martin S, Blankenship C, Rausch JW, Sztuba-Solinska J.

Methods. 2019 Apr 19. pii: S1046-2023(18)30366-9. doi: 10.1016/j.ymeth.2019.04.009. [Epub ahead of print] Review.


Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome.

Shilo A, Tosto FA, Rausch JW, Le Grice SFJ, Misteli T.

Nucleic Acids Res. 2019 Apr 22. pii: gkz259. doi: 10.1093/nar/gkz259. [Epub ahead of print]


APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R.

Okamoto K, Rausch JW, Wakashin H, Fu Y, Chung JY, Dummer PD, Shin MK, Chandra P, Suzuki K, Shrivastav S, Rosenberg AZ, Hewitt SM, Ray PE, Noiri E, Le Grice SFJ, Hoek M, Han Z, Winkler CA, Kopp JB.

Commun Biol. 2018 Nov 7;1:188. doi: 10.1038/s42003-018-0188-2. eCollection 2018.


Probing the Structures of Viral RNA Regulatory Elements with SHAPE and Related Methodologies.

Rausch JW, Sztuba-Solinska J, Le Grice SFJ.

Front Microbiol. 2018 Jan 9;8:2634. doi: 10.3389/fmicb.2017.02634. eCollection 2017. Review.


Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA: a structural scaffold for nuclear, cytoplasmic and viral proteins.

Sztuba-Solinska J, Rausch JW, Smith R, Miller JT, Whitby D, Le Grice SFJ.

Nucleic Acids Res. 2017 Jun 20;45(11):6805-6821. doi: 10.1093/nar/gkx241.


Reverse Transcription in the Saccharomyces cerevisiae Long-Terminal Repeat Retrotransposon Ty3.

Rausch JW, Miller JT, Le Grice SF.

Viruses. 2017 Mar 15;9(3). pii: E44. doi: 10.3390/v9030044. Review.


Novel Biochemical Tools for Probing HIV RNA Structure.

Rausch JW, Sztuba-Solinska J, Lusvarghi S, Le Grice SF.

Methods Mol Biol. 2016;1354:91-117. doi: 10.1007/978-1-4939-3046-3_7.


HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective.

Rausch JW, Le Grice SF.

Viruses. 2015 Jun 12;7(6):3053-75. doi: 10.3390/v7062760. Review.


SiRNA-induced mutation in HIV-1 polypurine tract region and its influence on viral fitness.

Rausch JW, Tian M, Li Y, Angelova L, Bagaya BS, Krebs KC, Qian F, Zhu C, Arts EJ, Le Grice SF, Gao Y.

PLoS One. 2015 Apr 10;10(4):e0122953. doi: 10.1371/journal.pone.0122953. eCollection 2015.


The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication.

Sherpa C, Rausch JW, Le Grice SF, Hammarskjold ML, Rekosh D.

Nucleic Acids Res. 2015 May 19;43(9):4676-86. doi: 10.1093/nar/gkv313. Epub 2015 Apr 8.


An unusual topological structure of the HIV-1 Rev response element.

Fang X, Wang J, O'Carroll IP, Mitchell M, Zuo X, Wang Y, Yu P, Liu Y, Rausch JW, Dyba MA, Kjems J, Schwieters CD, Seifert S, Winans RE, Watts NR, Stahl SJ, Wingfield PT, Byrd RA, Le Grice SF, Rein A, Wang YX.

Cell. 2013 Oct 24;155(3):594-605. doi: 10.1016/j.cell.2013.10.008. Epub 2013 Oct 24.


RNA secondary structure prediction using high-throughput SHAPE.

Lusvarghi S, Sztuba-Solinska J, Purzycka KJ, Rausch JW, Le Grice SF.

J Vis Exp. 2013 May 31;(75):e50243. doi: 10.3791/50243.


The HIV-2 Rev-response element: determining secondary structure and defining folding intermediates.

Lusvarghi S, Sztuba-Solinska J, Purzycka KJ, Pauly GT, Rausch JW, Grice SF.

Nucleic Acids Res. 2013 Jul;41(13):6637-49. doi: 10.1093/nar/gkt353. Epub 2013 May 2.


Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

Masaoka T, Chung S, Caboni P, Rausch JW, Wilson JA, Taskent-Sezgin H, Beutler JA, Tocco G, Le Grice SF.

J Med Chem. 2013 Jul 11;56(13):5436-45. doi: 10.1021/jm400405z. Epub 2013 Jun 20.


Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome.

Sztuba-Solinska J, Teramoto T, Rausch JW, Shapiro BA, Padmanabhan R, Le Grice SF.

Nucleic Acids Res. 2013 May;41(9):5075-89. doi: 10.1093/nar/gkt203. Epub 2013 Mar 26.


Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid.

Nowak E, Potrzebowski W, Konarev PV, Rausch JW, Bona MK, Svergun DI, Bujnicki JM, Le Grice SF, Nowotny M.

Nucleic Acids Res. 2013 Apr 1;41(6):3874-87. doi: 10.1093/nar/gkt053. Epub 2013 Feb 4.


Synthesis, activity, and structural analysis of novel ╬▒-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

Chung S, Himmel DM, Jiang JK, Wojtak K, Bauman JD, Rausch JW, Wilson JA, Beutler JA, Thomas CJ, Arnold E, Le Grice SF.

J Med Chem. 2011 Jul 14;54(13):4462-73. doi: 10.1021/jm2000757. Epub 2011 Jun 2.


Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.

Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF.

Antimicrob Agents Chemother. 2010 Sep;54(9):3913-21. doi: 10.1128/AAC.00434-10. Epub 2010 Jun 14.


HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN).

Chung NP, Breun SK, Bashirova A, Baumann JG, Martin TD, Karamchandani JM, Rausch JW, Le Grice SF, Wu L, Carrington M, Kewalramani VN.

J Biol Chem. 2010 Jan 15;285(3):2100-12. doi: 10.1074/jbc.M109.030619. Epub 2009 Oct 15.

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