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Items: 1 to 20 of 30

1.

Dehydroevodiamine•HCl Protects Against Memory Impairment and Cerebral Amyloid-β Production in Tg2576 Mice by Acting as a β-Secretase Inhibitor.

Shin KY, Noh SJ, Park CH, Jeong YH, Chang KA, Yoo J, Kim HJ, Ha S, Kim HS, Park HJ, Lee JH, Moon C, Suh YH.

CNS Neurol Disord Drug Targets. 2016;15(8):935-944.

PMID:
27577574
2.

Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.

Yoo J, Kim SJ, Son D, Seo H, Baek SY, Maeng CY, Lee C, Kim IS, Jung YH, Lee SM, Park HJ.

Eur J Med Chem. 2016 Jun 30;116:126-135. doi: 10.1016/j.ejmech.2016.03.046. Epub 2016 Mar 19.

PMID:
27060764
3.

Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases.

Song J, Yoo J, Kwon A, Kim D, Nguyen HK, Lee BY, Suh W, Min KH.

PLoS One. 2015 Sep 24;10(9):e0138823. doi: 10.1371/journal.pone.0138823. eCollection 2015.

4.

The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of L,D-Carboxypeptidase.

Kim HS, Im HN, An DR, Yoon JY, Jang JY, Mobashery S, Hesek D, Lee M, Yoo J, Cui M, Choi S, Kim C, Lee NK, Kim SJ, Kim JY, Bang G, Han BW, Lee BI, Yoon HJ, Suh SW.

J Biol Chem. 2015 Oct 9;290(41):25103-17. doi: 10.1074/jbc.M115.658781. Epub 2015 Aug 25.

5.

Resveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents.

Aldawsari FS, Aguayo-Ortiz R, Kapilashrami K, Yoo J, Luo M, Medina-Franco JL, Velázquez-Martínez CA.

J Enzyme Inhib Med Chem. 2016 Oct;31(5):695-703. doi: 10.3109/14756366.2015.1058256. Epub 2015 Jun 29.

6.

Discovery and development of DNA methyltransferase inhibitors using in silico approaches.

Medina-Franco JL, Méndez-Lucio O, Dueñas-González A, Yoo J.

Drug Discov Today. 2015 May;20(5):569-77. doi: 10.1016/j.drudis.2014.12.007. Epub 2014 Dec 16. Review.

PMID:
25526932
7.

Rationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking.

Medina-Franco JL, Méndez-Lucio O, Yoo J.

Int J Mol Sci. 2014 Feb 21;15(2):3253-61. doi: 10.3390/ijms15023253.

8.

Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.

Nayak A, Chandra G, Hwang I, Kim K, Hou X, Kim HO, Sahu PK, Roy KK, Yoo J, Lee Y, Cui M, Choi S, Moss SM, Phan K, Gao ZG, Ha H, Jacobson KA, Jeong LS.

J Med Chem. 2014 Feb 27;57(4):1344-54. doi: 10.1021/jm4015313. Epub 2014 Feb 5.

9.

Molecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: implications for the mechanism of inhibition of DNMTs.

Yoo J, Choi S, Medina-Franco JL.

PLoS One. 2013 Apr 25;8(4):e62152. doi: 10.1371/journal.pone.0062152. Print 2013.

10.

Docking of a novel DNA methyltransferase inhibitor identified from high-throughput screening: insights to unveil inhibitors in chemical databases.

Medina-Franco JL, Yoo J.

Mol Divers. 2013 May;17(2):337-44. doi: 10.1007/s11030-013-9428-z. Epub 2013 Feb 28.

PMID:
23447100
11.

Molecular modeling and virtual screening of DNA methyltransferase inhibitors.

Medina-Franco JL, Yoo J.

Curr Pharm Des. 2013;19(12):2138-47. Review.

PMID:
23016844
12.

CASE plots for the chemotype-based activity and selectivity analysis: a CASE study of cyclooxygenase inhibitors.

Pérez-Villanueva J, Medina-Franco JL, Méndez-Lucio O, Yoo J, Soria-Arteche O, Izquierdo T, Lozada MC, Castillo R.

Chem Biol Drug Des. 2012 Nov;80(5):752-62. doi: 10.1111/cbdd.12019. Epub 2012 Sep 10.

PMID:
22883137
13.
14.

Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor.

Yoo J, Kim JH, Robertson KD, Medina-Franco JL.

Adv Protein Chem Struct Biol. 2012;87:219-47. doi: 10.1016/B978-0-12-398312-1.00008-1. Review.

15.

Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors.

Castellano S, Kuck D, Viviano M, Yoo J, López-Vallejo F, Conti P, Tamborini L, Pinto A, Medina-Franco JL, Sbardella G.

J Med Chem. 2011 Nov 10;54(21):7663-77. doi: 10.1021/jm2010404. Epub 2011 Oct 7.

PMID:
21958292
16.

Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants.

Wang J, Singh US, Rawal RK, Sugiyama M, Yoo J, Jha AK, Scroggin M, Huang Z, Murray MG, Govindarajan R, Tanaka Y, Korba B, Chu CK.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6328-31. doi: 10.1016/j.bmcl.2011.08.113. Epub 2011 Sep 1. Erratum in: Bioorg Med Chem Lett. 2012 Apr 1;22(7):2641. Sugiyama, Massaya [corrected to Sugiyama, Masaya].

PMID:
21930377
17.

Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies.

Yoo J, Medina-Franco JL.

J Mol Model. 2012 Apr;18(4):1583-9. doi: 10.1007/s00894-011-1191-4. Epub 2011 Jul 30.

PMID:
21805123
18.

Homology modeling, docking and structure-based pharmacophore of inhibitors of DNA methyltransferase.

Yoo J, Medina-Franco JL.

J Comput Aided Mol Des. 2011 Jun;25(6):555-67. doi: 10.1007/s10822-011-9441-1. Epub 2011 Jun 10.

PMID:
21660514
19.

Synthesis and biological evaluation of 4(5)-(6-methylpyridin-2-yl)imidazoles and -pyrazoles as transforming growth factor-beta type 1 receptor kinase inhibitors.

Kim DK, Lee YI, Lee YW, Dewang PM, Sheen YY, Kim YW, Park HJ, Yoo J, Lee HS, Kim YK.

Bioorg Med Chem. 2010 Jun 15;18(12):4459-67. doi: 10.1016/j.bmc.2010.04.071. Epub 2010 Apr 28.

PMID:
20472445
20.

Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase.

Kim YA, Rawal RK, Yoo J, Sharon A, Jha AK, Chu CK, Rais RH, Al Safarjalani ON, Naguib FN, El Kouni MH.

Bioorg Med Chem. 2010 May 15;18(10):3403-12. doi: 10.1016/j.bmc.2010.04.003. Epub 2010 Apr 8.

PMID:
20456959

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