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New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises.

Lapoumeroulie C, Connes P, El Hoss S, Hierso R, Charlot K, Lemonne N, Elion J, Le Van Kim C, Romana M, Hardy-Dessources MD.

Br J Haematol. 2018 Nov 22. doi: 10.1111/bjh.15686. [Epub ahead of print] No abstract available.


Newborn screening for sickle cell disease in Europe: recommendations from a Pan-European Consensus Conference.

Lobitz S, Telfer P, Cela E, Allaf B, Angastiniotis M, Backman Johansson C, Badens C, Bento C, Bouva MJ, Canatan D, Charlton M, Coppinger C, Daniel Y, de Montalembert M, Ducoroy P, Dulin E, Fingerhut R, Frömmel C, García-Morin M, Gulbis B, Holtkamp U, Inusa B, James J, Kleanthous M, Klein J, Kunz JB, Langabeer L, Lapouméroulie C, Marcao A, Marín Soria JL, McMahon C, Ohene-Frempong K, Périni JM, Piel FB, Russo G, Sainati L, Schmugge M, Streetly A, Tshilolo L, Turner C, Venturelli D, Vilarinho L, Yahyaoui R, Elion J, Colombatti R; with the endorsement of EuroBloodNet, the European Reference Network in Rare Haematological Diseases.

Br J Haematol. 2018 Nov;183(4):648-660. doi: 10.1111/bjh.15600. Epub 2018 Oct 18.


The missing middle of sickle therapeutics: Multi-agent therapy, targeting risk, using biomarkers.

Hebbel RP, Elion J, Kutlar A.

Am J Hematol. 2018 Dec;93(12):1439-1443. doi: 10.1002/ajh.25289. Epub 2018 Oct 23. No abstract available.


A microfluidic approach to study the effect of mechanical stress on erythrocytes in sickle cell disease.

Lizarralde Iragorri MA, El Hoss S, Brousse V, Lefevre SD, Dussiot M, Xu T, Ferreira AR, Lamarre Y, Silva Pinto AC, Kashima S, Lapouméroulie C, Covas DT, Le Van Kim C, Colin Y, Elion J, Français O, Le Pioufle B, El Nemer W.

Lab Chip. 2018 Sep 26;18(19):2975-2984. doi: 10.1039/c8lc00637g.


New approach to accurate interpretation of sickle cell disease newborn screening by applying multiple of median cutoffs and ratios.

Allaf B, Patin F, Elion J, Couque N.

Pediatr Blood Cancer. 2018 Sep;65(9):e27230. doi: 10.1002/pbc.27230. Epub 2018 May 21.


Degree of anemia, indirect markers of hemolysis, and vascular complications of sickle cell disease in Africa.

Dubert M, Elion J, Tolo A, Diallo DA, Diop S, Diagne I, Sanogo I, Belinga S, Guifo O, Wamba G, Ngo Sack F, Boidy K, Kamara I, Traore Y, Diakite CO, Gbonon V, Faye BF, Seck M, Deme Ly I, Chelo D, N'Guetta R, Diop IB, Gaye B, Jouven X, Ranque B.

Blood. 2017 Nov 16;130(20):2215-2223. doi: 10.1182/blood-2016-12-755777. Epub 2017 Sep 20.


Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria.

Tétard M, Milet J, Dechavanne S, Fievet N, Dorin-Semblat D, Elion J, Fairhurst RM, Deloron P, Tuikue-Ndam N, Gamain B.

Sci Rep. 2017 May 3;7(1):1414. doi: 10.1038/s41598-017-01495-9.


Haemoglobin F, A2, and S levels in subjects with or without sickle cell trait in south-eastern Gabon.

Mombo LE, Mabioko-Mbembo G, Kassa-Kassa RF, Ontsitsagui E, Mboui-Ondo S, Nzé-Kamsi L, Nkoghé D, Elion J.

Hematology. 2017 Sep;22(8):508-513. doi: 10.1080/10245332.2017.1292622. Epub 2017 Feb 23.


[Dominique Labie (1920-2016)].

Elion J.

Med Sci (Paris). 2016 May;32(5):523-6. doi: 10.1051/medsci/20163205023. Epub 2016 May 25. French. No abstract available.


Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength.

Cita KC, Brureau L, Lemonne N, Billaud M, Connes P, Ferdinand S, Tressières B, Tarer V, Etienne-Julan M, Blanchet P, Elion J, Romana M.

PLoS One. 2016 May 4;11(5):e0154866. doi: 10.1371/journal.pone.0154866. eCollection 2016.


Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia.

Cita KC, Ferdinand S, Connes P, Brudey L, Tressières B, Etienne-Julan M, Lemonne N, Tarer V, Elion J, Romana M.

Blood Cells Mol Dis. 2016 May;58:21-5. doi: 10.1016/j.bcmd.2016.02.006. Epub 2016 Feb 18.


Improvement of medical care in a cohort of newborns with sickle-cell disease in North Paris: impact of national guidelines.

Couque N, Girard D, Ducrocq R, Boizeau P, Haouari Z, Missud F, Holvoet L, Ithier G, Belloy M, Odièvre MH, Benemou M, Benhaim P, Retali B, Bensaid P, Monier B, Brousse V, Amira R, Orzechowski C, Lesprit E, Mangyanda L, Garrec N, Elion J, Alberti C, Baruchel A, Benkerrou M.

Br J Haematol. 2016 Jun;173(6):927-37. doi: 10.1111/bjh.14015. Epub 2016 Apr 7.


The European Hematology Association Roadmap for European Hematology Research: a consensus document.

Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, de Wit TD, Eichinger S, Fibbe W, Green T, de Haas F, Iolascon A, Jaffredo T, Rodeghiero F, Salles G, Schuringa JJ; EHA Roadmap for European Hematology Research.

Haematologica. 2016 Feb;101(2):115-208. doi: 10.3324/haematol.2015.136739. Epub 2016 Jan 27.


Clinical and haematological risk factors for cerebral macrovasculopathy in a sickle cell disease newborn cohort: a prospective study.

Sommet J, Alberti C, Couque N, Verlhac S, Haouari Z, Mohamed D, François M, Missud F, Holvoet L, Elmaleh M, Ithier G, Denjean A, Elion J, Baruchel A, Benkerrou M.

Br J Haematol. 2016 Mar;172(6):966-77. doi: 10.1111/bjh.13916. Epub 2016 Jan 5.


[Sickle cell disease: pneumococcus escapes prevention and adapts to the disease. Consequences on vaccine design].

Labie D, Elion J.

Med Sci (Paris). 2014 Nov;30(11):946-8. doi: 10.1051/medsci/20143011005. Epub 2014 Nov 10. French. No abstract available.


Hydroxycarbamide modulates components involved in the regulation of adenosine levels in blood cells from sickle-cell anemia patients.

Silva-Pinto AC, Dias-Carlos C, Saldanha-Araujo F, Ferreira FI, Palma PV, Araujo AG, Queiroz RH, Elion J, Covas DT, Zago MA, Panepucci RA.

Ann Hematol. 2014 Sep;93(9):1457-65. doi: 10.1007/s00277-014-2066-4. Epub 2014 Apr 3.


Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation.

Chaar V, Laurance S, Lapoumeroulie C, Cochet S, De Grandis M, Colin Y, Elion J, Le Van Kim C, El Nemer W.

J Biol Chem. 2014 Apr 18;289(16):11512-21. doi: 10.1074/jbc.M113.506121. Epub 2014 Mar 10.


Impact of glucose-6-phosphate dehydrogenase deficiency on sickle cell anaemia expression in infancy and early childhood: a prospective study.

Benkerrou M, Alberti C, Couque N, Haouari Z, Ba A, Missud F, Boizeau P, Holvoet L, Ithier G, Elion J, Baruchel A, Ducrocq R.

Br J Haematol. 2013 Dec;163(5):646-54. doi: 10.1111/bjh.12590. Epub 2013 Oct 10.


Prior exposure of endothelial cells to hydroxycarbamide alters the flow dynamics and adhesion of sickle red blood cells.

Verger E, Schoëvaërt D, Carrivain P, Victor JM, Lapouméroulie C, Elion J.

Clin Hemorheol Microcirc. 2014;57(1):9-22. doi: 10.3233/CH-131762.


Fetal hemoglobin and hydroxycarbamide moduate both plasma concentration and cellular origin of circulating microparticles in sickle cell anemia children.

Nébor D, Romana M, Santiago R, Vachiery N, Picot J, Broquere C, Chaar V, Doumdo L, Odièvre MH, Benkerrou M, Elion J.

Haematologica. 2013 Jun;98(6):862-7. doi: 10.3324/haematol.2012.073619. Epub 2013 Feb 12.

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