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Items: 1 to 20 of 81

1.

In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds.

Evenseth LM, Warszycki D, Bojarski AJ, Gabrielsen M, Sylte I.

Molecules. 2019 Mar 7;24(5). pii: E935. doi: 10.3390/molecules24050935.

2.

The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases.

Sylte I, Dawadi R, Malla N, von Hofsten S, Nguyen TM, Solli AI, Berg E, Adekoya OA, Svineng G, Winberg JO.

PLoS One. 2018 Aug 3;13(8):e0200237. doi: 10.1371/journal.pone.0200237. eCollection 2018.

3.

In Silico Site-Directed Mutagenesis Informs Species-Specific Predictions of Chemical Susceptibility Derived From the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) Tool.

Doering JA, Lee S, Kristiansen K, Evenseth L, Barron MG, Sylte I, LaLone CA.

Toxicol Sci. 2018 Nov 1;166(1):131-145. doi: 10.1093/toxsci/kfy186.

PMID:
30060110
4.

Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol.

Al-Kazaale N, Tran PT, Haidari F, Solum EJ, Liekens S, Vervaeke P, Sylte I, Cheng JJ, Vik A, Hansen TV.

Steroids. 2018 Aug;136:47-55. doi: 10.1016/j.steroids.2018.05.002. Epub 2018 May 18.

PMID:
29772242
5.

In Vitro and in Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants with Human and Gull Thyroid Hormone Transport Proteins.

Hill KL, Mortensen ÅK, Teclechiel D, Willmore WG, Sylte I, Jenssen BM, Letcher RJ.

Environ Sci Technol. 2018 Feb 6;52(3):1533-1541. doi: 10.1021/acs.est.7b04617. Epub 2018 Jan 16.

PMID:
29283575
6.

Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations.

Ara A, Kadoya R, Ishimura H, Shimamura K, Sylte I, Kurita N.

J Mol Graph Model. 2017 Aug;75:277-286. doi: 10.1016/j.jmgm.2017.05.013. Epub 2017 Jun 8.

PMID:
28618335
7.

Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents.

Chilmonczyk Z, Bojarski AJ, Pilc A, Sylte I.

Pharmacol Rep. 2017 Jun;69(3):469-478. doi: 10.1016/j.pharep.2017.01.011. Epub 2017 Jan 22. Review.

PMID:
28324844
8.

Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor.

Freyd T, Warszycki D, Mordalski S, Bojarski AJ, Sylte I, Gabrielsen M.

PLoS One. 2017 Mar 21;12(3):e0173889. doi: 10.1371/journal.pone.0173889. eCollection 2017.

9.

From Homology Models to a Set of Predictive Binding Pockets-a 5-HT1A Receptor Case Study.

Warszycki D, Rueda M, Mordalski S, Kristiansen K, Satała G, Rataj K, Chilmonczyk Z, Sylte I, Abagyan R, Bojarski AJ.

J Chem Inf Model. 2017 Feb 27;57(2):311-321. doi: 10.1021/acs.jcim.6b00263. Epub 2017 Jan 18.

10.

Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations.

Viktorsson EÖ, Gabrielsen M, Kumarachandran N, Sylte I, Rongved P, Åstrand OA, Kase ET.

Steroids. 2017 Feb;118:119-127. doi: 10.1016/j.steroids.2016.12.003. Epub 2016 Dec 21.

PMID:
28011133
11.

Environmental Chemicals Modulate Polar Bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and Adipogenesis in Vitro.

Routti H, Lille-Langøy R, Berg MK, Fink T, Harju M, Kristiansen K, Rostkowski P, Rusten M, Sylte I, Øygarden L, Goksøyr A.

Environ Sci Technol. 2016 Oct 4;50(19):10708-10720. Epub 2016 Sep 19.

PMID:
27602593
12.

Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors.

Åstrand OAH, Viktorsson EÖ, Kristensen AL, Ekeberg D, Røberg-Larsen H, Wilson SR, Gabrielsen M, Sylte I, Rustan AC, Thoresen GH, Rongved P, Kase ET.

J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):323-330. doi: 10.1016/j.jsbmb.2016.07.010. Epub 2016 Jul 26.

PMID:
27471149
13.

Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.

Sjøli S, Nuti E, Camodeca C, Bilto I, Rossello A, Winberg JO, Sylte I, Adekoya OA.

Eur J Med Chem. 2016 Jan 27;108:141-153. doi: 10.1016/j.ejmech.2015.11.019. Epub 2015 Nov 28.

PMID:
26638045
14.

Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands.

Chilmonczyk Z, Bojarski AJ, Pilc A, Sylte I.

Int J Mol Sci. 2015 Aug 7;16(8):18474-506. doi: 10.3390/ijms160818474. Review.

15.

High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification.

Odunuga OO, Adekoya OA, Sylte I.

Protein Expr Purif. 2015 Sep;113:79-84. doi: 10.1016/j.pep.2015.05.005. Epub 2015 May 12.

PMID:
25979480
16.

Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618.

Kaupang Å, Paulsen SM, Steindal CC, Ravna AW, Sylte I, Halvorsen TG, Thoresen GH, Hansen TV.

Eur J Med Chem. 2015 Apr 13;94:229-36. doi: 10.1016/j.ejmech.2015.03.006. Epub 2015 Mar 5.

PMID:
25768705
17.

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.

Adekoya OA, Sjøli S, Wuxiuer Y, Bilto I, Marques SM, Santos MA, Nuti E, Cercignani G, Rossello A, Winberg JO, Sylte I.

Eur J Med Chem. 2015 Jan 7;89:340-8. doi: 10.1016/j.ejmech.2014.10.009. Epub 2014 Oct 18.

PMID:
25462250
18.

Ligand-directed trafficking of receptor stimulus.

Chilmonczyk Z, Bojarski AJ, Sylte I.

Pharmacol Rep. 2014 Dec;66(6):1011-21. doi: 10.1016/j.pharep.2014.06.006. Epub 2014 Jun 26. Review.

PMID:
25443729
19.

Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines.

Jantan I, Bukhari SN, Adekoya OA, Sylte I.

Drug Des Devel Ther. 2014 Sep 16;8:1405-18. doi: 10.2147/DDDT.S67370. eCollection 2014.

20.

PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors.

Sjøli S, Solli AI, Akselsen O, Jiang Y, Berg E, Hansen TV, Sylte I, Winberg JO.

Biochim Biophys Acta. 2014 Oct;1840(10):3162-9. doi: 10.1016/j.bbagen.2014.07.011. Epub 2014 Jul 18.

PMID:
25046380

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