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Items: 1 to 20 of 59

1.

3-Furan-2-yl-N-p-tolyl-acrylamide, a highly selective positive allosteric modulator of α7 nicotinic receptors, produces anxiolytic-like activity in mice.

Targowska-Duda KM, Budzynska B, Michalak A, Jozwiak K, Biala G, Arias HR.

J Psychopharmacol. 2019 May;33(5):558-567. doi: 10.1177/0269881118821100. Epub 2019 Jan 15.

PMID:
30644335
2.

Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms.

Arias HR, Vázquez-Gómez E, Hernández-Abrego A, Gallino S, Feuerbach D, Ortells MO, Elgoyhen AB, García-Colunga J.

Int J Biochem Cell Biol. 2018 Jul;100:1-10. doi: 10.1016/j.biocel.2018.04.017. Epub 2018 Apr 25.

PMID:
29704625
3.

Positive allosteric modulators of α7* or β2* nicotinic acetylcholine receptors trigger different kinase pathways in mitochondria.

Uspenska K, Lykhmus O, Arias HR, Pons S, Maskos U, Komisarenko S, Skok M.

Int J Biochem Cell Biol. 2018 Jun;99:226-235. doi: 10.1016/j.biocel.2018.04.018. Epub 2018 Apr 25.

PMID:
29704624
4.

Drimane Sesquiterpenoids Noncompetitively Inhibit Human α4β2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human α3β4 and α7 Subtypes.

Arias HR, Feuerbach D, Schmidt B, Heydenreich M, Paz C, Ortells MO.

J Nat Prod. 2018 Apr 27;81(4):811-817. doi: 10.1021/acs.jnatprod.7b00893. Epub 2018 Apr 10.

PMID:
29634269
5.

Molecular interactions of type I and type II positive allosteric modulators with the human α7 nicotinic acetylcholine receptor: an in silico study.

Targowska-Duda KM, Kaczor AA, Jozwiak K, Arias HR.

J Biomol Struct Dyn. 2019 Feb;37(2):411-439. doi: 10.1080/07391102.2018.1427634. Epub 2018 Feb 16.

PMID:
29363414
6.

Coronaridine congeners modulate mitochondrial α3β4* nicotinic acetylcholine receptors with different potency and through distinct intra-mitochondrial pathways.

Arias HR, Lykhmus O, Uspenska K, Skok M.

Neurochem Int. 2018 Mar;114:26-32. doi: 10.1016/j.neuint.2017.12.008. Epub 2017 Dec 23.

PMID:
29277577
7.

Selectivity of coronaridine congeners at nicotinic acetylcholine receptors and inhibitory activity on mouse medial habenula.

Arias HR, Jin X, Feuerbach D, Drenan RM.

Int J Biochem Cell Biol. 2017 Nov;92:202-209. doi: 10.1016/j.biocel.2017.10.006. Epub 2017 Oct 16.

8.

Nicotine facilitates nicotinic acetylcholine receptor targeting to mitochondria but makes them less susceptible to selective ligands.

Uspenska K, Lykhmus O, Gergalova G, Chernyshov V, Arias HR, Komisarenko S, Skok M.

Neurosci Lett. 2017 Aug 24;656:43-50. doi: 10.1016/j.neulet.2017.07.009. Epub 2017 Jul 9.

PMID:
28700952
9.

Significance of the nicotinic alpha7 receptor in cognition and antipsychotic-like behavior in the rat.

Wadenberg MG, Manetti D, Romanelli MN, Arias HR.

Behav Brain Res. 2017 Aug 30;333:129-134. doi: 10.1016/j.bbr.2017.07.001. Epub 2017 Jul 3.

PMID:
28684359
10.

3-Furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic receptor, reverses schizophrenia-like cognitive and social deficits in rats.

Potasiewicz A, Hołuj M, Kos T, Popik P, Arias HR, Nikiforuk A.

Neuropharmacology. 2017 Feb;113(Pt A):188-197. doi: 10.1016/j.neuropharm.2016.10.002. Epub 2016 Oct 4.

PMID:
27717880
11.

Bupropion and its photoreactive analog (±)-SADU-3-72 interact with luminal and non-luminal sites at human α4β2 nicotinic acetylcholine receptors.

Arias HR, Feuerbach D, Ortells MO.

Neurochem Int. 2016 Nov;100:67-77. doi: 10.1016/j.neuint.2016.08.013. Epub 2016 Sep 6.

PMID:
27612850
12.

Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.

Arias HR, Ravazzini F, Targowska-Duda KM, Kaczor AA, Feuerbach D, Boffi JC, Draczkowski P, Montag D, Brown BM, Elgoyhen AB, Jozwiak K, Puia G.

Int J Biochem Cell Biol. 2016 Jul;76:19-30. doi: 10.1016/j.biocel.2016.04.015. Epub 2016 Apr 26.

PMID:
27129924
13.

Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective.

Andersen ND, Nielsen BE, Corradi J, Tolosa MF, Feuerbach D, Arias HR, Bouzat C.

Neuropharmacology. 2016 Aug;107:189-200. doi: 10.1016/j.neuropharm.2016.02.032. Epub 2016 Feb 27.

PMID:
26926428
14.

Role of Nicotinic and Muscarinic Receptors on Synaptic Plasticity and Neurological Diseases.

Fuenzalida M, Pérez MÁ, Arias HR.

Curr Pharm Des. 2016;22(14):2004-14. Review.

PMID:
26818867
15.

The positive allosteric modulator of α7 nicotinic acetylcholine receptors, 3-furan-2-yl-N-p-tolyl-acrylamide, enhances memory processes and stimulates ERK1/2 phosphorylation in mice.

Targowska-Duda KM, Wnorowski A, Budzynska B, Jozwiak K, Biala G, Arias HR.

Behav Brain Res. 2016 Apr 1;302:142-51. doi: 10.1016/j.bbr.2016.01.002. Epub 2016 Jan 8.

PMID:
26778787
16.

The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors in Mice.

Bagdas D, Targowska-Duda KM, López JJ, Perez EG, Arias HR, Damaj MI.

Anesth Analg. 2015 Nov;121(5):1369-77. doi: 10.1213/ANE.0000000000000902.

17.

Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile.

Möller-Acuña P, Contreras-Riquelme JS, Rojas-Fuentes C, Nuñez-Vivanco G, Alzate-Morales J, Iturriaga-Vásquez P, Arias HR, Reyes-Parada M.

PLoS One. 2015 Aug 5;10(8):e0134444. doi: 10.1371/journal.pone.0134444. eCollection 2015.

18.

The antidepressant-like activity of nicotine, but not of 3-furan-2-yl-N-p-tolyl-acrylamide, is regulated by the nicotinic receptor β4 subunit.

Arias HR, Targowska-Duda KM, Feuerbach D, Jozwiak K.

Neurochem Int. 2015 Aug;87:110-6. doi: 10.1016/j.neuint.2015.06.006. Epub 2015 Jun 23.

PMID:
26116439
19.

Coronaridine congeners inhibit human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites.

Arias HR, Targowska-Duda KM, Feuerbach D, Jozwiak K.

Int J Biochem Cell Biol. 2015 Aug;65:81-90. doi: 10.1016/j.biocel.2015.05.015. Epub 2015 May 27.

PMID:
26022277
20.

Functional and structural interaction of (-)-lobeline with human α4β2 and α4β4 nicotinic acetylcholine receptor subtypes.

Arias HR, Feuerbach D, Ortells M.

Int J Biochem Cell Biol. 2015 Jul;64:15-24. doi: 10.1016/j.biocel.2015.03.003. Epub 2015 Mar 18.

PMID:
25794424

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