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Mono- and poly-functional T cells in nontuberculous mycobacteria lung disease patients: Implications in analyzing risk of disease progression.

Shu CC, Wu LS, Wu MF, Lai HC, Wang PH, Cheng SL, Wang JY, Yu CJ.

Cytokine. 2019 May 11;120:176-185. doi: 10.1016/j.cyto.2019.05.001. [Epub ahead of print]


Probiotic Lactobacillus spp. act Against Helicobacter pylori-induced Inflammation.

Chen YH, Tsai WH, Wu HY, Chen CY, Yeh WL, Chen YH, Hsu HY, Chen WW, Chen YW, Chang WW, Lin TL, Lai HC, Lin YH, Lai CH.

J Clin Med. 2019 Jan 14;8(1). pii: E90. doi: 10.3390/jcm8010090.


Probiotics, prebiotics and amelioration of diseases.

Tsai YL, Lin TL, Chang CJ, Wu TR, Lai WF, Lu CC, Lai HC.

J Biomed Sci. 2019 Jan 4;26(1):3. doi: 10.1186/s12929-018-0493-6. Review.


NK Cell-Derived IFN-γ Protects against Nontuberculous Mycobacterial Lung Infection.

Lai HC, Chang CJ, Lin CS, Wu TR, Hsu YJ, Wu TS, Lu JJ, Martel J, Ojcius DM, Ku CL, Young JD, Lu CC.

J Immunol. 2018 Sep 1;201(5):1478-1490. doi: 10.4049/jimmunol.1800123. Epub 2018 Jul 30.


Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis.

Wu TR, Lin CS, Chang CJ, Lin TL, Martel J, Ko YF, Ojcius DM, Lu CC, Young JD, Lai HC.

Gut. 2019 Feb;68(2):248-262. doi: 10.1136/gutjnl-2017-315458. Epub 2018 Jul 14.


Interleukin 23/interleukin 17 axis activated by Mycobacterium avium complex (MAC) is attenuated in patients with MAC-lung disease.

Shu CC, Wang JY, Wu MF, Lai HC, Chiang BL, Yu CJ.

Tuberculosis (Edinb). 2018 May;110:7-14. doi: 10.1016/ Epub 2018 Mar 3.


The ATP-P2X7 Signaling Axis Is an Essential Sentinel for Intracellular Clostridium difficile Pathogen-Induced Inflammasome Activation.

Liu YH, Chang YC, Chen LK, Su PA, Ko WC, Tsai YS, Chen YH, Lai HC, Wu CY, Hung YP, Tsai PJ.

Front Cell Infect Microbiol. 2018 Mar 16;8:84. doi: 10.3389/fcimb.2018.00084. eCollection 2018.


Antrodia cinnamomea produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway.

Huang TT, Lan YW, Ko YF, Chen CM, Lai HC, Ojcius DM, Martel J, Young JD, Chong KY.

J Ethnopharmacol. 2018 Jun 28;220:239-249. doi: 10.1016/j.jep.2018.03.041. Epub 2018 Mar 30.


Antimicrobial resistance in Mycobacterium abscessus complex isolated from patients with skin and soft tissue infections at a tertiary teaching hospital in Taiwan.

Lee MC, Sun PL, Wu TL, Wang LH, Yang CH, Chung WH, Kuo AJ, Liu TP, Lu JJ, Chiu CH, Lai HC, Chen NY, Yang JH, Wu TS.

J Antimicrob Chemother. 2017 Oct 1;72(10):2782-2786. doi: 10.1093/jac/dkx212.


Myths and Realities Surrounding the Mysterious Caterpillar Fungus.

Martel J, Ko YF, Liau JC, Lee CS, Ojcius DM, Lai HC, Young JD.

Trends Biotechnol. 2017 Nov;35(11):1017-1021. doi: 10.1016/j.tibtech.2017.06.011.


Effects of obesity on depression: A role for inflammation and the gut microbiota.

Schachter J, Martel J, Lin CS, Chang CJ, Wu TR, Lu CC, Ko YF, Lai HC, Ojcius DM, Young JD.

Brain Behav Immun. 2018 Mar;69:1-8. doi: 10.1016/j.bbi.2017.08.026. Epub 2017 Sep 6. Review.


Immunomodulatory Properties of Plants and Mushrooms.

Martel J, Ko YF, Ojcius DM, Lu CC, Chang CJ, Lin CS, Lai HC, Young JD.

Trends Pharmacol Sci. 2017 Nov;38(11):967-981. doi: 10.1016/ Epub 2017 Aug 30.


Corrigendum: Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.

Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, Tseng SF, Wu TR, Chen YM, Young JD, Lai HC.

Nat Commun. 2017 Jul 11;8:16130. doi: 10.1038/ncomms16130.


Decreased T helper 17 cells in tuberculosis is associated with increased percentages of programmed death ligand 1, T helper 2 and regulatory T cells.

Shu CC, Wu MF, Wang JY, Lai HC, Lee LN, Chiang BL, Yu CJ.

Respir Res. 2017 Jun 26;18(1):128. doi: 10.1186/s12931-017-0580-3.


Cross-talk between bacterial two-component systems drives stepwise regulation of flagellar biosynthesis in swarming development.

Wei CF, Tsai YH, Tsai SH, Lin CS, Chang CJ, Lu CC, Huang HC, Lai HC.

Biochem Biophys Res Commun. 2017 Jul 15;489(1):70-75. doi: 10.1016/j.bbrc.2017.05.077. Epub 2017 May 15.


Attenuation of lymphocyte immune responses during Mycobacterium avium complex-induced lung disease due to increasing expression of programmed death-1 on lymphocytes.

Shu CC, Wang JY, Wu MF, Wu CT, Lai HC, Lee LN, Chiang BL, Yu CJ.

Sci Rep. 2017 Feb 7;7:42004. doi: 10.1038/srep42004.


Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells.

Wu TR, Huang TT, Martel J, Liau JC, Chiu CY, Leu YL, Jian WT, Chang IT, Lu CC, Ojcius DM, Ko YF, Lai HC, Young JD.

J Ethnopharmacol. 2017 Apr 6;201:117-122. doi: 10.1016/j.jep.2017.02.008. Epub 2017 Feb 4.


Isolation, Culture and Characterization of Hirsutella sinensis Mycelium from Caterpillar Fungus Fruiting Body.

Ko YF, Liau JC, Lee CS, Chiu CY, Martel J, Lin CS, Tseng SF, Ojcius DM, Lu CC, Lai HC, Young JD.

PLoS One. 2017 Jan 3;12(1):e0168734. doi: 10.1371/journal.pone.0168734. eCollection 2017.


An iron detection system determines bacterial swarming initiation and biofilm formation.

Lin CS, Tsai YH, Chang CJ, Tseng SF, Wu TR, Lu CC, Wu TS, Lu JJ, Horng JT, Martel J, Ojcius DM, Lai HC, Young JD.

Sci Rep. 2016 Nov 15;6:36747. doi: 10.1038/srep36747.


Anti-obesogenic and antidiabetic effects of plants and mushrooms.

Martel J, Ojcius DM, Chang CJ, Lin CS, Lu CC, Ko YF, Tseng SF, Lai HC, Young JD.

Nat Rev Endocrinol. 2017 Mar;13(3):149-160. doi: 10.1038/nrendo.2016.142. Epub 2016 Sep 16. Review.


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