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Bioreactor-Controlled Physoxia Regulates TGF-β Signaling to Alter Extracellular Matrix Synthesis by Human Chondrocytes.

Jahr H, Gunes S, Kuhn AR, Nebelung S, Pufe T.

Int J Mol Sci. 2019 Apr 6;20(7). pii: E1715. doi: 10.3390/ijms20071715.


Nrf2 ameliorates DDC-induced sclerosing cholangitis and biliary fibrosis and improves the regenerative capacity of the liver.

Fragoulis A, Schenkel J, Herzog M, Schellenberg T, Jahr H, Pufe T, Trautwein C, Kensler TW, Streetz KL, Wruck CJ.

Toxicol Sci. 2019 Mar 2. pii: kfz055. doi: 10.1093/toxsci/kfz055. [Epub ahead of print]


Increased TGF-β and BMP Levels and Improved Chondrocyte-Specific Marker Expression In Vitro under Cartilage-Specific Physiological Osmolarity.

Tan Timur U, Caron M, van den Akker G, van der Windt A, Visser J, van Rhijn L, Weinans H, Welting T, Emans P, Jahr H.

Int J Mol Sci. 2019 Feb 13;20(4). pii: E795. doi: 10.3390/ijms20040795.


Quantitative articular cartilage sub-surface defect assessment using optical coherence tomography: An in-vitro study.

Michalik R, Pauer T, Brill N, Knobe M, Tingart M, Jahr H, Truhn D, Nebelung S.

Ann Anat. 2019 Jan;221:125-134. doi: 10.1016/j.aanat.2018.10.001. Epub 2018 Oct 9.


MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12.

Lian WS, Ko JY, Wu RW, Sun YC, Chen YS, Wu SL, Weng LH, Jahr H, Wang FS.

Cell Death Dis. 2018 Sep 11;9(9):919. doi: 10.1038/s41419-018-0994-y.


Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes under Inflammatory Joint Disease.

Tohidnezhad M, Bayer A, Rasuo B, Hock JVP, Kweider N, Fragoulis A, Sönmez TT, Jahr H, Pufe T, Lippross S.

Mediators Inflamm. 2017;2017:1046438. doi: 10.1155/2017/1046438. Epub 2017 Nov 19.


Platelet-released growth factors inhibit proliferation of primary keratinocytes in vitro.

Bayer A, Tohidnezhad M, Berndt R, Lippross S, Behrendt P, Klüter T, Pufe T, Jahr H, Cremer J, Rademacher F, Simanski M, Gläser R, Harder J.

Ann Anat. 2018 Jan;215:1-7. doi: 10.1016/j.aanat.2017.09.002. Epub 2017 Sep 18.


The Antimicrobial Peptide Human Beta-Defensin-3 Is Induced by Platelet-Released Growth Factors in Primary Keratinocytes.

Bayer A, Lammel J, Tohidnezhad M, Lippross S, Behrendt P, Klüter T, Pufe T, Cremer J, Jahr H, Rademacher F, Gläser R, Harder J.

Mediators Inflamm. 2017;2017:6157491. doi: 10.1155/2017/6157491. Epub 2017 Jul 25.


Platelet-Released Growth Factors Induce Differentiation of Primary Keratinocytes.

Bayer A, Tohidnezhad M, Lammel J, Lippross S, Behrendt P, Klüter T, Pufe T, Jahr H, Cremer J, Rademacher F, Gläser R, Harder J.

Mediators Inflamm. 2017;2017:5671615. doi: 10.1155/2017/5671615. Epub 2017 Jul 20.


The protective effect of platelet released growth factors and bone augmentation (Bio-Oss®) on ethanol impaired osteoblasts.

Sönmez TT, Bayer A, Cremer T, Hock JVP, Lethaus B, Kweider N, Wruck CJ, Drescher W, Jahr H, Lippross S, Pufe T, Tohidnezhad M.

Ann Anat. 2017 Nov;214:36-42. doi: 10.1016/j.aanat.2017.07.002. Epub 2017 Jul 31.


Functional in situ assessment of human articular cartilage using MRI: a whole-knee joint loading device.

Nebelung S, Post M, Raith S, Fischer H, Knobe M, Braun B, Prescher A, Tingart M, Thüring J, Bruners P, Jahr H, Kuhl C, Truhn D.

Biomech Model Mechanobiol. 2017 Dec;16(6):1971-1986. doi: 10.1007/s10237-017-0932-4. Epub 2017 Jul 6.


Platelet-released growth factors induce psoriasin in keratinocytes: Implications for the cutaneous barrier.

Bayer A, Lammel J, Lippross S, Klüter T, Behrendt P, Tohidnezhad M, Pufe T, Cremer J, Jahr H, Rademacher F, Gläser R, Harder J.

Ann Anat. 2017 Sep;213:25-32. doi: 10.1016/j.aanat.2017.04.002. Epub 2017 May 25.


Ex vivo quantitative multiparametric MRI mapping of human meniscus degeneration.

Nebelung S, Tingart M, Pufe T, Kuhl C, Jahr H, Truhn D.

Skeletal Radiol. 2016 Dec;45(12):1649-1660. Epub 2016 Sep 17.


Functional MR Imaging Mapping of Human Articular Cartilage Response to Loading.

Nebelung S, Sondern B, Oehrl S, Tingart M, Rath B, Pufe T, Raith S, Fischer H, Kuhl C, Jahr H, Truhn D.

Radiology. 2017 Feb;282(2):464-474. doi: 10.1148/radiol.2016160053. Epub 2016 Aug 26.


Effect of platelet mediator concentrate (PMC) on Achilles tenocytes: an in vitro study.

Arslan E, Nellesen T, Bayer A, Prescher A, Lippross S, Nebelung S, Jahr H, Jaeger C, Huebner WD, Fischer H, Stoffel M, Shakibaei M, Pufe T, Tohidnezhad M.

BMC Musculoskelet Disord. 2016 Jul 22;17:307. doi: 10.1186/s12891-016-1160-2.


Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration.

Brill N, Wirtz M, Merhof D, Tingart M, Jahr H, Truhn D, Schmitt R, Nebelung S.

J Biomed Opt. 2016 Jul 1;21(7):76013. doi: 10.1117/1.JBO.21.7.076013.


Detecting early stage osteoarthritis by optical coherence tomography?

Jahr H, Brill N, Nebelung S.

Biomarkers. 2015;20(8):590-6. doi: 10.3109/1354750X.2015.1130190. Epub 2016 Feb 10. Review.


Cell surface syndecan-1 contributes to binding and function of macrophage migration inhibitory factor (MIF) on epithelial tumor cells.

Pasqualon T, Lue H, Groening S, Pruessmeyer J, Jahr H, Denecke B, Bernhagen J, Ludwig A.

Biochim Biophys Acta. 2016 Apr;1863(4):717-26. doi: 10.1016/j.bbamcr.2016.02.003. Epub 2016 Feb 4.


Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration.

Nebelung S, Brill N, Tingart M, Pufe T, Kuhl C, Jahr H, Truhn D.

Skeletal Radiol. 2016 Apr;45(4):505-16. doi: 10.1007/s00256-016-2334-6. Epub 2016 Jan 19.


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