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Items: 1 to 20 of 37

1.

Belizatinib: Novel reactive intermediates and bioactivation pathways characterized by LC-MS/MS.

Attwa MW, Kadi AA, Darwish HW.

J Pharm Biomed Anal. 2019 Jul 15;171:132-147. doi: 10.1016/j.jpba.2019.04.006. Epub 2019 Apr 6.

PMID:
30999224
2.

Identification of reactive intermediate formation and bioactivation pathways in Abemaciclib metabolism by LC-MS/MS: in vitro metabolic investigation.

Kadi AA, Darwish HW, Abuelizz HA, Alsubi TA, Attwa MW.

R Soc Open Sci. 2019 Jan 23;6(1):181714. doi: 10.1098/rsos.181714. eCollection 2019 Jan.

3.

Development of novel response surface methodology-assisted micellar enhanced synchronous spectrofluorimetric method for determination of vandetanib in tablets, human plasma and urine.

Darwish HW, Bakheit AH, Al-Shakliah NS, Darwish IA.

Spectrochim Acta A Mol Biomol Spectrosc. 2019 Apr 15;213:272-280. doi: 10.1016/j.saa.2019.01.056. Epub 2019 Jan 16.

PMID:
30703710
4.

Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC-ESI-MS/MS.

Attwa MW, Kadi AA, Darwish HW, Amer SM, Al-Shakliah NS.

Chem Cent J. 2018 Sep 24;12(1):99. doi: 10.1186/s13065-018-0467-5.

5.

LC-MS/MS reveals the formation of iminium and quinone methide reactive intermediates in entrectinib metabolism: In vivo and in vitro metabolic investigation.

Attwa MW, Kadi AA, Alrabiah H, Darwish HW.

J Pharm Biomed Anal. 2018 Oct 25;160:19-30. doi: 10.1016/j.jpba.2018.07.032. Epub 2018 Jul 22.

PMID:
30055343
6.

Investigation of metabolic degradation of new ALK inhibitor: Entrectinib by LC-MS/MS.

Attwa MW, Darwish HW, Alhazmi HA, Kadi AA.

Clin Chim Acta. 2018 Oct;485:298-304. doi: 10.1016/j.cca.2018.07.009. Epub 2018 Jul 10.

PMID:
30006284
7.

Five modified classical least squares based models for stability indicating analysis of cyclobenzaprine HCl with its major degradation products: A comparative study.

Darwish HW, Naguib IA, Darwish IA.

Spectrochim Acta A Mol Biomol Spectrosc. 2018 Nov 5;204:598-602. doi: 10.1016/j.saa.2018.06.101. Epub 2018 Jun 28.

PMID:
29980061
8.

LC-ESI-MS/MS identification and characterization of ponatinib in vivo phase I and phase II metabolites.

Attwa MW, Kadi AA, Darwish HW, Amer SM, AlRabiah H.

Clin Chim Acta. 2018 Oct;485:144-151. doi: 10.1016/j.cca.2018.06.035. Epub 2018 Jun 30.

PMID:
29966620
9.

Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry.

Kadi AA, Amer SM, Darwish HW, Attwa MW.

Chem Cent J. 2018 May 15;12(1):61. doi: 10.1186/s13065-018-0429-y.

10.

A reliable and stable method for the determination of foretinib in human plasma by LC-MS/MS: Application to metabolic stability investigation and excretion rate.

Attwa MW, Kadi AA, Darwish HW, Amer SM, Alrabiah H.

Eur J Mass Spectrom (Chichester). 2018 Aug;24(4):344-351. doi: 10.1177/1469066718768327. Epub 2018 Apr 8.

PMID:
29629565
11.

LC-MS/MS reveals the formation of reactive ortho-quinone and iminium intermediates in saracatinib metabolism: Phase I metabolic profiling.

Attwa MW, Kadi AA, Darwish HW, Alrabiah H.

Clin Chim Acta. 2018 Jul;482:84-94. doi: 10.1016/j.cca.2018.03.037. Epub 2018 Mar 31.

PMID:
29614307
12.

Investigation of metabolic stability of the novel ALK inhibitor brigatinib by liquid chromatography tandem mass spectrometry.

Darwish HW, Kadi AA, Attwa MW, Almutairi HS.

Clin Chim Acta. 2018 May;480:180-185. doi: 10.1016/j.cca.2018.02.016. Epub 2018 Feb 16.

PMID:
29458050
13.

LC-MS/MS method for the quantification of masitinib in RLMs matrix and rat urine: application to metabolic stability and excretion rate.

Amer SM, Kadi AA, Darwish HW, Attwa MW.

Chem Cent J. 2017 Dec 22;11(1):136. doi: 10.1186/s13065-017-0365-2.

14.
16.

Validated LC-MS/MS Method for the Quantification of Ponatinib in Plasma: Application to Metabolic Stability.

Kadi AA, Darwish HW, Attwa MW, Amer SM.

PLoS One. 2016 Oct 20;11(10):e0164967. doi: 10.1371/journal.pone.0164967. eCollection 2016.

17.

Fluorescence spectroscopic and molecular docking studies of the binding interaction between the new anaplastic lymphoma kinase inhibitor crizotinib and bovine serum albumin.

Abdelhameed AS, Alanazi AM, Bakheit AH, Darwish HW, Ghabbour HA, Darwish IA.

Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jan 15;171:174-182. doi: 10.1016/j.saa.2016.08.005. Epub 2016 Aug 5.

PMID:
27526341
18.

Full spectrum and selected spectrum based multivariate calibration methods for simultaneous determination of betamethasone dipropionate, clotrimazole and benzyl alcohol: Development, validation and application on commercial dosage form.

Darwish HW, Elzanfaly ES, Saad AS, Abdelaleem Ael-B.

Spectrochim Acta A Mol Biomol Spectrosc. 2016 Dec 5;169:50-7. doi: 10.1016/j.saa.2016.06.001. Epub 2016 Jun 3.

PMID:
27327260
19.
20.

Comparative Study of Novel Ratio Spectra and Isoabsorptive Point Based Spectrophotometric Methods: Application on a Binary Mixture of Ascorbic Acid and Rutin.

Darwish HW, Bakheit AH, Naguib IA.

J Anal Methods Chem. 2016;2016:2828647. doi: 10.1155/2016/2828647. Epub 2016 Jan 18.

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