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Cancers (Basel). 2019 Feb 3;11(2). pii: E179. doi: 10.3390/cancers11020179.

Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029.

Author information

1
Université Clermont Auvergne, INSERM1071, Microbes, Intestins, Inflammation et Susceptibilité de l'hôte, 63001 Clermont-Ferrand CEDEX 1, France. mathilde.bonnet@uca.fr.
2
Université Clermont Auvergne, INSERM U1240, Imagerie Moléculaire et Stratégies Théranostiques, F-63000 Clermont Ferrand, France. aurelie.maisonial@uca.fr.
3
Université Paris-Sud, INSERM U935, Bâtiment Lavoisier, 14 Avenue Paul-Vaillant-Couturier, F-94800 Villejuif, France. julianzyy@hotmail.com.
4
Université Clermont Auvergne, INSERM U1240, Imagerie Moléculaire et Stratégies Théranostiques, F-63000 Clermont Ferrand, France. tiffany.witkowski@inserm.fr.
5
Université Clermont Auvergne, INSERM1071, Microbes, Intestins, Inflammation et Susceptibilité de l'hôte, 63001 Clermont-Ferrand CEDEX 1, France. gwenaelle.roche@uca.fr.
6
Université Paris-Sud, INSERM U935, Bâtiment Lavoisier, 14 Avenue Paul-Vaillant-Couturier, F-94800 Villejuif, France. claude.boucheix@inserm.fr.
7
Université Paris-Sud, INSERM U935, Bâtiment Lavoisier, 14 Avenue Paul-Vaillant-Couturier, F-94800 Villejuif, France. celine.greco@inserm.fr.
8
Department of Pain and Palliative Medicine AP HP, Hôpital Necker, 75015 Paris, France. celine.greco@inserm.fr.
9
Université Clermont Auvergne, INSERM U1240, Imagerie Moléculaire et Stratégies Théranostiques, F-63000 Clermont Ferrand, France. francoise.degoul@inserm.fr.

Abstract

Tetraspanins are exposed at the surface of cellular membranes, which allows for the fixation of cognate antibodies. Developing specific antibodies in conjunction with genetic data would largely contribute to deciphering their biological behavior. In this short review, we summarize the main functions of Tspan8/Co-029 and its role in the biology of tumor cells. Based on data collected from recently reported studies, the possibilities of using antibodies to target Tspan8 in immunotherapy or radioimmunotherapy approaches are also discussed.

KEYWORDS:

Tspan8; cancer; immunotherapy; radioimmunotherapy; tetraspanins

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