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Viruses. 2018 May 9;10(5). pii: E248. doi: 10.3390/v10050248.

Molecular and Clinical Characterization of Chikungunya Virus Infections in Southeast Mexico.

Author information

1
Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo Leon, Av. Francisco I. Madero S/N, Mitras Centro, Monterrey, 64460 Nuevo Leon, Mexico. kame.galanhr@uanl.edu.mx.
2
Hospital Metropolitano Dr. Bernardo Sepulveda, Secretaría de Salud de Nuevo Leon, Adolfo Lopez Mateos No. 4600, Bosques del Nogalar, San Nicolas de los Garza, 66480 Nuevo Leon, Mexico. dr_erikmtz@itesm.mx.
3
Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo Leon, Av. Francisco I. Madero S/N, Mitras Centro, Monterrey, 64460 Nuevo Leon, Mexico. juan_luisdg@outlook.com.
4
Clínica Hospital Dr. Roberto Nettel Flores, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Av. Tuxtepec y Oaxaca S/N, Francisco Villa, Tapachula, 30740 Chiapas, Mexico. sandyluzcs@hotmail.com.
5
Centro Regional de Investigación en Salud Publica, Instituto Nacional de Salud Publica 4a Avenida Norte, esquina con calle 19 poniente S/N, Centro, Tapachula, 30700 Chiapas, Mexico. malo@insp.mx.
6
Centro Regional de Investigación en Salud Publica, Instituto Nacional de Salud Publica 4a Avenida Norte, esquina con calle 19 poniente S/N, Centro, Tapachula, 30700 Chiapas, Mexico. ildefonso.fernandezsl@uanl.edu.mx.
7
Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Av. Pedro de Alba S/N, Ciudad Universitaria, San Nicolas de los Garza, 66455 Nuevo Leon, Mexico. ildefonso.fernandezsl@uanl.edu.mx.
8
Servicio de Infectologia-Hospital Universitario Dr. Jose Eleuterio Gonzalez, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Av. Francisco I. Madero and Eduardo Aguirre Pequeño S/N, Mitras Centro, Monterrey, 64460 Nuevo Leon, Mexico. javramos31@gmail.com.
9
Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo Leon, Av. Francisco I. Madero S/N, Mitras Centro, Monterrey, 64460 Nuevo Leon, Mexico. ana.rivasst@uanl.edu.mx.

Abstract

Chikungunya fever is an arthropod-borne infection caused by Chikungunya virus (CHIKV). Even though clinical features of Chikungunya fever in the Mexican population have been described before, there is no detailed information. The aim of this study was to perform a full description of the clinical features in confirmed Chikungunya-infected patients and describe the molecular epidemiology of CHIKV. We evaluated febrile patients who sought medical assistance in Tapachula, Chiapas, Mexico, from June through July 2015. Infection was confirmed with molecular and serological methods. Viruses were isolated and the E1 gene was sequenced. Phylogeny reconstruction was inferred using maximum-likelihood and maximum clade credibility approaches. We studied 52 patients with confirmed CHIKV infection. They were more likely to have wrist, metacarpophalangeal, and knee arthralgia. Two combinations of clinical features were obtained to differentiate between Chikungunya fever and acute undifferentiated febrile illness. We obtained 10 CHIKV E1 sequences that grouped with the Asian lineage. Seven strains diverged from the formerly reported. Patients infected with the divergent CHIKV strains showed a broader spectrum of clinical manifestations. We defined the complete clinical features of Chikungunya fever in patients from Southeastern Mexico. Our results demonstrate co-circulation of different CHIKV strains in the state of Chiapas.

KEYWORDS:

Chikungunya fever; Mexico; alphavirus; phylogeny

PMID:
29747416
PMCID:
PMC5977241
DOI:
10.3390/v10050248
[Indexed for MEDLINE]
Free PMC Article

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