Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 15

1.

Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritin.

Pozzi C, Di Pisa F, Lalli D, Rosa C, Turano P, Mangani S.

J Inorg Biochem. 2019 May 7;197:110697. doi: 10.1016/j.jinorgbio.2019.110697. [Epub ahead of print]

PMID:
31075719
2.

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.

Linciano P, Pozzi C, Iacono LD, di Pisa F, Landi G, Bonucci A, Gul S, Kuzikov M, Ellinger B, Witt G, Santarem N, Baptista C, Franco C, Moraes CB, Müller W, Wittig U, Luciani R, Sesenna A, Quotadamo A, Ferrari S, Pöhner I, Cordeiro-da-Silva A, Mangani S, Costantino L, Costi MP.

J Med Chem. 2019 Apr 25;62(8):3989-4012. doi: 10.1021/acs.jmedchem.8b02021. Epub 2019 Apr 9.

PMID:
30908048
3.

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.

Moraes CB, Witt G, Kuzikov M, Ellinger B, Calogeropoulou T, Prousis KC, Mangani S, Di Pisa F, Landi G, Iacono LD, Pozzi C, Freitas-Junior LH, Dos Santos Pascoalino B, Bertolacini CP, Behrens B, Keminer O, Leu J, Wolf M, Reinshagen J, Cordeiro-da-Silva A, Santarem N, Venturelli A, Wrigley S, Karunakaran D, Kebede B, Pöhner I, Müller W, Panecka-Hofman J, Wade RC, Fenske M, Clos J, Alunda JM, Corral MJ, Uliassi E, Bolognesi ML, Linciano P, Quotadamo A, Ferrari S, Santucci M, Borsari C, Costi MP, Gul S.

SLAS Discov. 2019 Mar;24(3):346-361. doi: 10.1177/2472555218823171.

PMID:
30784368
4.

The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders.

Pozzi C, Di Pisa F, Benvenuti M, Mangani S.

J Biol Inorg Chem. 2018 Dec;23(8):1219-1226. doi: 10.1007/s00775-018-1605-1. Epub 2018 Aug 21.

PMID:
30132075
5.

Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam.

Pozzi C, Di Pisa F, De Luca F, Benvenuti M, Docquier JD, Mangani S.

ChemMedChem. 2018 Jul 18;13(14):1437-1446. doi: 10.1002/cmdc.201800213. Epub 2018 Jun 20.

PMID:
29786960
6.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.

Linciano P, Dawson A, Pöhner I, Costa DM, Sá MS, Cordeiro-da-Silva A, Luciani R, Gul S, Witt G, Ellinger B, Kuzikov M, Gribbon P, Reinshagen J, Wolf M, Behrens B, Hannaert V, Michels PAM, Nerini E, Pozzi C, di Pisa F, Landi G, Santarem N, Ferrari S, Saxena P, Lazzari S, Cannazza G, Freitas-Junior LH, Moraes CB, Pascoalino BS, Alcântara LM, Bertolacini CP, Fontana V, Wittig U, Müller W, Wade RC, Hunter WN, Mangani S, Costantino L, Costi MP.

ACS Omega. 2017 Sep 30;2(9):5666-5683. doi: 10.1021/acsomega.7b00473. Epub 2017 Sep 11.

7.

Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors.

Panecka-Hofman J, Pöhner I, Spyrakis F, Zeppelin T, Di Pisa F, Dello Iacono L, Bonucci A, Quotadamo A, Venturelli A, Mangani S, Costi MP, Wade RC.

Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3215-3230. doi: 10.1016/j.bbagen.2017.09.012. Epub 2017 Sep 20.

PMID:
28939533
8.

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.

Di Pisa F, Landi G, Dello Iacono L, Pozzi C, Borsari C, Ferrari S, Santucci M, Santarem N, Cordeiro-da-Silva A, Moraes CB, Alcantara LM, Fontana V, Freitas-Junior LH, Gul S, Kuzikov M, Behrens B, Pöhner I, Wade RC, Costi MP, Mangani S.

Molecules. 2017 Mar 8;22(3). pii: E426. doi: 10.3390/molecules22030426.

9.

Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster.

Pozzi C, Ciambellotti S, Bernacchioni C, Di Pisa F, Mangani S, Turano P.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2580-2585. doi: 10.1073/pnas.1614302114. Epub 2017 Feb 15.

10.

Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.

Bernacchioni C, Pozzi C, Di Pisa F, Mangani S, Turano P.

Chemistry. 2016 Nov 2;22(45):16213-16219. doi: 10.1002/chem.201602842. Epub 2016 Sep 21.

PMID:
27650996
11.

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.

Borsari C, Luciani R, Pozzi C, Poehner I, Henrich S, Trande M, Cordeiro-da-Silva A, Santarem N, Baptista C, Tait A, Di Pisa F, Dello Iacono L, Landi G, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Gribbon P, Kohler M, Keminer O, Behrens B, Costantino L, Tejera Nevado P, Bifeld E, Eick J, Clos J, Torrado J, Jiménez-Antón MD, Corral MJ, Alunda JM, Pellati F, Wade RC, Ferrari S, Mangani S, Costi MP.

J Med Chem. 2016 Aug 25;59(16):7598-616. doi: 10.1021/acs.jmedchem.6b00698. Epub 2016 Aug 5.

PMID:
27411733
12.

Iron binding to human heavy-chain ferritin.

Pozzi C, Di Pisa F, Bernacchioni C, Ciambellotti S, Turano P, Mangani S.

Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1909-20. doi: 10.1107/S1399004715013073. Epub 2015 Aug 25.

PMID:
26327381
13.

Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.

Pozzi C, Di Pisa F, Lalli D, Rosa C, Theil E, Turano P, Mangani S.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):941-53. doi: 10.1107/S1399004715002333. Epub 2015 Mar 27.

14.

Loop electrostatics modulates the intersubunit interactions in ferritin.

Bernacchioni C, Ghini V, Pozzi C, Di Pisa F, Theil EC, Turano P.

ACS Chem Biol. 2014 Nov 21;9(11):2517-25. doi: 10.1021/cb500431r. Epub 2014 Aug 29.

PMID:
25148224
15.

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.

Ferrari S, Calò S, Leone R, Luciani R, Costantino L, Sammak S, Di Pisa F, Pozzi C, Mangani S, Costi MP.

J Med Chem. 2013 Nov 27;56(22):9356-60. doi: 10.1021/jm4014086. Epub 2013 Nov 13.

PMID:
24147825

Supplemental Content

Loading ...
Support Center