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Items: 1 to 20 of 136

1.

The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells.

Cerna T, Hrabeta J, Eckschlager T, Frei E, Schmeiser HH, Arlt VM, Stiborová M.

Int J Mol Sci. 2018 Jan 5;19(1). pii: E164. doi: 10.3390/ijms19010164.

2.

Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.

Stiborová M, Indra R, Frei E, Kopečková K, Schmeiser HH, Eckschlager T, Adam V, Heger Z, Arlt VM, Martínek V.

Monatsh Chem. 2017;148(11):1983-1991. doi: 10.1007/s00706-017-1986-9. Epub 2017 Jul 4.

3.

Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches.

Martínek V, Bárta F, Hodek P, Frei E, Schmeiser HH, Arlt VM, Stiborová M.

Monatsh Chem. 2017;148(11):1971-1981. doi: 10.1007/s00706-017-2014-9. Epub 2017 Jul 26.

4.

Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems.

Stiborová M, Indra R, Moserová M, Bořek-Dohalská L, Hodek P, Frei E, Kopka K, Schmeiser HH, Arlt VM.

Monatsh Chem. 2017;148(11):1959-1969. doi: 10.1007/s00706-017-2002-0. Epub 2017 Jul 10.

5.

Effectiveness of human cytochrome P450 3A4 present in liposomal and microsomal nanoparticles in formation of covalent DNA adducts by ellipticine.

Sulc M, Mrizova I, Cerna T, Frei E, Eckschlager T, Adam V, Kopeckova K, Stiborova M.

Neuro Endocrinol Lett. 2016 Dec 18;37(Suppl1):95-102.

PMID:
28263536
6.

Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.

Stiborová M, Indra R, Moserová M, Frei E, Schmeiser HH, Kopka K, Phillips DH, Arlt VM.

Chem Res Toxicol. 2016 Sep 19;29(9):1571. doi: 10.1021/acs.chemrestox.6b00283. Epub 2016 Aug 30. No abstract available.

7.

NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.

Stiborová M, Indra R, Moserová M, Frei E, Schmeiser HH, Kopka K, Phillips DH, Arlt VM.

Chem Res Toxicol. 2016 Aug 15;29(8):1325-34. doi: 10.1021/acs.chemrestox.6b00143. Epub 2016 Jul 20. Erratum in: Chem Res Toxicol. 2016 Sep 19;29(9):1571.

8.

Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).

Stiborová M, Moserová M, Mrízová I, Dračínská H, Martínek V, Indra R, Frei E, Adam V, Kizek R, Schmeiser HH, Kubáčková K, Arlt VM.

Monatsh Chem. 2016;147:897-904. Epub 2016 Jan 12.

9.

NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1.

Stiborová M, Indra R, Moserová M, Šulc M, Hodek P, Frei E, Schmeiser HH, Arlt VM.

Monatsh Chem. 2016;147:847-855. Epub 2016 Mar 9.

10.

The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers.

Šulc M, Indra R, Moserová M, Schmeiser HH, Frei E, Arlt VM, Stiborová M.

Environ Mol Mutagen. 2016 Apr;57(3):229-35. doi: 10.1002/em.22001. Epub 2016 Feb 26.

11.

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.

Milichovský J, Bárta F, Schmeiser HH, Arlt VM, Frei E, Stiborová M, Martínek V.

Int J Mol Sci. 2016 Feb 5;17(2):213. doi: 10.3390/ijms17020213.

12.

Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo.

Dračínská H, Bárta F, Levová K, Hudecová A, Moserová M, Schmeiser HH, Kopka K, Frei E, Arlt VM, Stiborová M.

Toxicology. 2016 Feb 17;344-346:7-18. doi: 10.1016/j.tox.2016.01.011. Epub 2016 Feb 1.

13.

Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro.

Stiborova M, Manhartova Z, Hodek P, Adam V, Kizek R, Eckschlager T, Frei E.

Neuro Endocrinol Lett. 2015;36 Suppl 1:22-8.

PMID:
26757112
14.

Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance.

Hrabeta J, Adam V, Eckschlager T, Frei E, Stiborova M, Kizek R.

Anticancer Agents Med Chem. 2016;16(6):686-98. Review.

PMID:
26584725
15.

Changes in urinary metabolic profiles of colorectal cancer patients enrolled in a prospective cohort study (ColoCare).

Liesenfeld DB, Habermann N, Toth R, Owen RW, Frei E, Staffa J, Schrotz-King P, Klika KD, Ulrich CM.

Metabolomics. 2015 Aug;11(4):998-1012. doi: 10.1007/s11306-014-0758-3. Epub 2014 Dec 20.

16.

Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells.

Hrabeta J, Groh T, Khalil MA, Poljakova J, Adam V, Kizek R, Uhlik J, Doktorova H, Cerna T, Frei E, Stiborova M, Eckschlager T.

Int J Oncol. 2015 Sep;47(3):971-80. doi: 10.3892/ijo.2015.3066. Epub 2015 Jun 29.

PMID:
26134421
17.

Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene.

Arlt VM, Krais AM, Godschalk RW, Riffo-Vasquez Y, Mrizova I, Roufosse CA, Corbin C, Shi Q, Frei E, Stiborova M, van Schooten FJ, Phillips DH, Spina D.

Toxicol Sci. 2015 Aug;146(2):213-25. doi: 10.1093/toxsci/kfv086. Epub 2015 Apr 23.

18.

Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer.

Beyerle J, Frei E, Stiborova M, Habermann N, Ulrich CM.

Drug Metab Rev. 2015 May;47(2):199-221. doi: 10.3109/03602532.2014.996649. Epub 2015 Feb 17. Review.

PMID:
25686853
19.

Enzymes oxidizing the azo dye 1-phenylazo-2-naphthol (Sudan I) and their contribution to its genotoxicity and carcinogenicity.

Stiborova M, Schmeiser HH, Frei E, Hodek P, Martinek V.

Curr Drug Metab. 2014;15(8):829-40. Review.

PMID:
25658126
20.

Effect of dihydromyricetin on benzo[a]pyrene activation in rats.

Hodek P, Fousova P, Brabencova E, Moserova M, Pavek P, Anzenbacherova E, Brotanek J, Hudecek J, Frei E, Stiborova M.

Neuro Endocrinol Lett. 2014;35 Suppl 2:158-68.

PMID:
25638381

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