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Items: 1 to 20 of 33


The dual roles of RPE65 S-palmitoylation in membrane association and visual cycle function.

Uppal S, Liu T, Poliakov E, Gentleman S, Redmond TM.

Sci Rep. 2019 Mar 26;9(1):5218. doi: 10.1038/s41598-019-41501-w.


Volatile Evolution of Long Non-Coding RNA Repertoire in Retinal Pigment Epithelium: Insights from Comparison of Bovine and Human RNA Expression Profiles.

Postnikova OA, Rogozin IB, Samuel W, Nudelman G, Babenko VN, Poliakov E, Redmond TM.

Genes (Basel). 2019 Mar 8;10(3). pii: E205. doi: 10.3390/genes10030205.


Aberrant RNA splicing is the major pathogenic effect in a knock-in mouse model of the dominantly inherited c.1430A>G human RPE65 mutation.

Li Y, Furhang R, Ray A, Duncan T, Soucy J, Mahdi R, Chaitankar V, Gieser L, Poliakov E, Qian H, Liu P, Dong L, Rogozin IB, Redmond TM.

Hum Mutat. 2019 Apr;40(4):426-443. doi: 10.1002/humu.23706. Epub 2019 Jan 25.


Genome-Wide Changes in Protein Translation Efficiency Are Associated with Autism.

Rogozin IB, Gertz EM, Baranov PV, Poliakov E, Schaffer AA.

Genome Biol Evol. 2018 Aug 1;10(8):1902-1919. doi: 10.1093/gbe/evy146.


Phylogenetic analysis of the metazoan carotenoid oxygenase superfamily: a new ancestral gene assemblage of BCO-like (BCOL) proteins.

Poliakov E, Soucy J, Gentleman S, Rogozin IB, Redmond TM.

Sci Rep. 2017 Oct 16;7(1):13192. doi: 10.1038/s41598-017-13521-x.


Mutational signatures and mutable motifs in cancer genomes.

Rogozin IB, Pavlov YI, Goncearenco A, De S, Lada AG, Poliakov E, Panchenko AR, Cooper DN.

Brief Bioinform. 2018 Nov 27;19(6):1085-1101. doi: 10.1093/bib/bbx049.


Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells.

Samuel W, Jaworski C, Postnikova OA, Kutty RK, Duncan T, Tan LX, Poliakov E, Lakkaraju A, Redmond TM.

Mol Vis. 2017 Mar 5;23:60-89. eCollection 2017.


Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration.

Golestaneh N, Chu Y, Cheng SK, Cao H, Poliakov E, Berinstein DM.

J Transl Med. 2016 Dec 20;14(1):344. doi: 10.1186/s12967-016-1101-8.


Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism.

Eroglu A, Gentleman S, Poliakov E, Redmond TM.

J Biol Chem. 2016 Mar 4;291(10):4966-73. doi: 10.1074/jbc.M115.685651. Epub 2015 Dec 30.


Transposable Element Insertions in Long Intergenic Non-Coding RNA Genes.

Kannan S, Chernikova D, Rogozin IB, Poliakov E, Managadze D, Koonin EV, Milanesi L.

Front Bioeng Biotechnol. 2015 Jun 9;3:71. doi: 10.3389/fbioe.2015.00071. eCollection 2015.


Genetics in genomic era.

Poliakov E, Cooper DN, Stepchenkova EI, Rogozin IB.

Genet Res Int. 2015;2015:364960. doi: 10.1155/2015/364960. Epub 2015 Mar 25. No abstract available.


Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness.

Meller J, Rogozin IB, Poliakov E, Meller N, Bedanov-Pack M, Plow EF, Qin J, Podrez EA, Byzova TV.

Mol Biol Cell. 2015 Feb 15;26(4):786-96. doi: 10.1091/mbc.E14-08-1294. Epub 2014 Dec 24.


Generalized portrait of cancer metabolic pathways inferred from a list of genes overexpressed in cancer.

Poliakov E, Managadze D, Rogozin IB.

Genet Res Int. 2014;2014:646193. doi: 10.1155/2014/646193. Epub 2014 Aug 27.


Impairment of translation in neurons as a putative causative factor for autism.

Poliakov E, Koonin EV, Rogozin IB.

Biol Direct. 2014 Jul 10;9:16. doi: 10.1186/1745-6150-9-16.


Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells.

Poliakov E, Strunnikova NV, Jiang JK, Martinez B, Parikh T, Lakkaraju A, Thomas C, Brooks BP, Redmond TM.

Mol Vis. 2014 Mar 14;20:285-300. eCollection 2014.


Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates.

Poliakov E, Gubin AN, Stearn O, Li Y, Campos MM, Gentleman S, Rogozin IB, Redmond TM.

PLoS One. 2012;7(11):e49975. doi: 10.1371/journal.pone.0049975. Epub 2012 Nov 27.


Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression.

Chander P, Gentleman S, Poliakov E, Redmond TM.

J Biol Chem. 2012 Aug 31;287(36):30552-9. doi: 10.1074/jbc.M112.364596. Epub 2012 Jun 28.


The mechanism of fenretinide (4-HPR) inhibition of β-carotene monooxygenase 1. New suspect for the visual side effects of fenretinide.

Poliakov E, Gubin A, Laird J, Gentleman S, Salomon RG, Redmond TM.

Adv Exp Med Biol. 2012;723:167-74. doi: 10.1007/978-1-4614-0631-0_23. No abstract available.


Aromatic lipophilic spin traps effectively inhibit RPE65 isomerohydrolase activity.

Poliakov E, Parikh T, Ayele M, Kuo S, Chander P, Gentleman S, Redmond TM.

Biochemistry. 2011 Aug 16;50(32):6739-41. doi: 10.1021/bi200532m. Epub 2011 Jul 13.

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