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Items: 1 to 20 of 214

1.

Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response.

Lupieri A, Smirnova NF, Solinhac R, Malet N, Benamar M, Saoudi A, Santos-Zas I, Zeboudj L, Ait-Oufella H, Hirsch E, Ohayon P, Lhermusier T, Carrié D, Arnal JF, Ramel D, Gayral S, Laffargue M.

Cardiovasc Res. 2019 May 20. pii: cvz122. doi: 10.1093/cvr/cvz122. [Epub ahead of print]

PMID:
31106375
2.

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction.

Tiosano D, Baris HN, Chen A, Hitzert MM, Schueler M, Gulluni F, Wiesener A, Bergua A, Mory A, Copeland B, Gleeson JG, Rump P, van Meer H, Sival DA, Haucke V, Kriwinsky J, Knaup KX, Reis A, Hauer NN, Hirsch E, Roepman R, Pfundt R, Thiel CT, Wiesener MS, Aslanyan MG, Buchner DA.

PLoS Genet. 2019 Apr 29;15(4):e1008088. doi: 10.1371/journal.pgen.1008088. eCollection 2019 Apr.

3.

Targeting PI3K signaling in cancer: Challenges and advances.

De Santis MC, Gulluni F, Campa CC, Martini M, Hirsch E.

Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):361-366. doi: 10.1016/j.bbcan.2019.03.003. Epub 2019 Apr 1. Review.

PMID:
30946868
4.

Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking.

Margaria JP, Ratto E, Gozzelino L, Li H, Hirsch E.

Biomolecules. 2019 Mar 15;9(3). pii: E104. doi: 10.3390/biom9030104. Review.

5.

The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity.

Russo M, Guida F, Paparo L, Trinchese G, Aitoro R, Avagliano C, Fiordelisi A, Napolitano F, Mercurio V, Sala V, Li M, Sorriento D, Ciccarelli M, Ghigo A, Hirsch E, Bianco R, Iaccarino G, Abete P, Bonaduce D, Calignano A, Berni Canani R, Tocchetti CG.

Eur J Heart Fail. 2019 Apr;21(4):519-528. doi: 10.1002/ejhf.1439. Epub 2019 Mar 6.

PMID:
30843309
6.

New pre-clinical evidence of anti-inflammatory effect and safety of a substituted fluorophenyl imidazole.

Dos Santos Nascimento MVP, Mattar Munhoz AC, De Campos Facchin BM, Fratoni E, Rossa TA, Mandolesi Sá M, Campa CC, Ciraolo E, Hirsch E, Dalmarco EM.

Biomed Pharmacother. 2019 Mar;111:1399-1407. doi: 10.1016/j.biopha.2019.01.052. Epub 2019 Jan 19.

7.

Late onset heart failure after childhood chemotherapy.

Hilfiker-Kleiner D, Ardehali H, Fischmeister R, Burridge P, Hirsch E, Lyon AR.

Eur Heart J. 2019 Mar 7;40(10):798-800. doi: 10.1093/eurheartj/ehz046. No abstract available.

PMID:
30753420
8.

Class II PI3K Functions in Cell Biology and Disease.

Gulluni F, De Santis MC, Margaria JP, Martini M, Hirsch E.

Trends Cell Biol. 2019 Apr;29(4):339-359. doi: 10.1016/j.tcb.2019.01.001. Epub 2019 Jan 25. Review.

PMID:
30691999
9.

The Inhibition of Phosphoinositide-3 Kinases Induce Resolution of Inflammation in a Gout Model.

Galvão I, Queiroz-Junior CM, de Oliveira VLS, Pinho V, Hirsch E, Teixeira MM.

Front Pharmacol. 2019 Jan 7;9:1505. doi: 10.3389/fphar.2018.01505. eCollection 2018.

10.

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.

Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E.

Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6.

11.

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE.

Nat Commun. 2018 Sep 14;9(1):3772. doi: 10.1038/s41467-018-06196-z.

12.

Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.

Zamboni V, Jones R, Umbach A, Ammoni A, Passafaro M, Hirsch E, Merlo GR.

Int J Mol Sci. 2018 Jun 20;19(6). pii: E1821. doi: 10.3390/ijms19061821. Review.

13.

Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes.

Campa CC, Margaria JP, Derle A, Del Giudice M, De Santis MC, Gozzelino L, Copperi F, Bosia C, Hirsch E.

Nat Chem Biol. 2018 Aug;14(8):801-810. doi: 10.1038/s41589-018-0086-4. Epub 2018 Jun 18.

PMID:
29915378
14.

Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.

Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR.

Sci Rep. 2018 May 8;8(1):7254. doi: 10.1038/s41598-018-25354-3.

15.

Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.

Wyart E, Reano S, Hsu MY, Longo DL, Li M, Hirsch E, Filigheddu N, Ghigo A, Riganti C, Porporato PE.

Oxid Med Cell Longev. 2018 Feb 26;2018:6419805. doi: 10.1155/2018/6419805. eCollection 2018.

16.

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.

Silva MC, Davoli-Ferreira M, Medina TS, Sesti-Costa R, Silva GK, Lopes CD, Cardozo LE, Gava FN, Lyroni K, Dias FC, Frade AF, Baron M, Nakaya HI, Figueiredo F, Alves-Filho JC, Cunha FQ, Tsatsanis C, Chevillard C, Cunha-Neto E, Hirsch E, Silva JS, Cunha TM.

Nat Commun. 2018 Apr 17;9(1):1513. doi: 10.1038/s41467-018-03986-3.

17.

Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression.

Porta C, Ippolito A, Consonni FM, Carraro L, Celesti G, Correale C, Grizzi F, Pasqualini F, Tartari S, Rinaldi M, Bianchi P, Balzac F, Vetrano S, Turco E, Hirsch E, Laghi L, Sica A.

Cancer Immunol Res. 2018 May;6(5):578-593. doi: 10.1158/2326-6066.CIR-17-0036. Epub 2018 Mar 27.

18.

Functions of PDE3 Isoforms in Cardiac Muscle.

Movsesian M, Ahmad F, Hirsch E.

J Cardiovasc Dev Dis. 2018 Feb 6;5(1). pii: E10. doi: 10.3390/jcdd5010010. Review.

19.

The turtle and the rabbit story in a modern (PI3)key.

Martini M, De Santis MC, Hirsch E.

Mol Cell Oncol. 2017 Dec 7;5(1):e1405141. doi: 10.1080/23723556.2017.1405141. eCollection 2018.

20.

Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth.

Li M, Sala V, De Santis MC, Cimino J, Cappello P, Pianca N, Di Bona A, Margaria JP, Martini M, Lazzarini E, Pirozzi F, Rossi L, Franco I, Bornbaum J, Heger J, Rohrbach S, Perino A, Tocchetti CG, Lima BHF, Teixeira MM, Porporato PE, Schulz R, Angelini A, Sandri M, Ameri P, Sciarretta S, Lima-Júnior RCP, Mongillo M, Zaglia T, Morello F, Novelli F, Hirsch E, Ghigo A.

Circulation. 2018 Aug 14;138(7):696-711. doi: 10.1161/CIRCULATIONAHA.117.030352.

PMID:
29348263

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