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Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines.

Durães F, Sousa E.

Pharmaceuticals (Basel). 2019 Apr 21;12(2). pii: E63. doi: 10.3390/ph12020063.


BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease.

Maia MA, Sousa E.

Pharmaceuticals (Basel). 2019 Mar 19;12(1). pii: E41. doi: 10.3390/ph12010041. Review.


Antithrombotics from the Sea: Polysaccharides and Beyond.

Carvalhal F, Cristelo RR, Resende DISP, Pinto MMM, Sousa E, Correia-da-Silva M.

Mar Drugs. 2019 Mar 16;17(3). pii: E170. doi: 10.3390/md17030170. Review.


The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells.

Reis-Mendes A, Carvalho F, Remião F, Sousa E, Bastos ML, Costa VM.

Biomolecules. 2019 Mar 11;9(3). pii: E98. doi: 10.3390/biom9030098.


Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: In Vitro, Ex Vivo, and In Silico Studies.

Martins E, Silva V, Lemos A, Palmeira A, Puthongking P, Sousa E, Rocha-Pereira C, Ghanem CI, Carmo H, Remião F, Silva R.

Molecules. 2019 Feb 15;24(4). pii: E707. doi: 10.3390/molecules24040707.


Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects.

Long S, Resende DISP, Kijjoa A, Silva AMS, Fernandes R, Xavier CPR, Vasconcelos MH, Sousa E, Pinto MMM.

Molecules. 2019 Feb 1;24(3). pii: E534. doi: 10.3390/molecules24030534.


Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations.

Alves A, Correia-da-Silva M, Nunes C, Campos J, Sousa E, Silva PMA, Bousbaa H, Rodrigues F, Ferreira D, Costa PC, Pinto M.

Molecules. 2019 Jan 23;24(3). pii: E409. doi: 10.3390/molecules24030409.


New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma.

Gomes S, Raimundo L, Soares J, Loureiro JB, Leão M, Ramos H, Monteiro MN, Lemos A, Moreira J, Pinto M, Chlapek P, Veselska R, Sousa E, Saraiva L.

Cancer Lett. 2019 Apr 1;446:90-102. doi: 10.1016/j.canlet.2019.01.014. Epub 2019 Jan 19.


The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization.

Lima RT, Sousa D, Gomes AS, Mendes N, Matthiesen R, Pedro M, Marques F, Pinto MM, Sousa E, Vasconcelos MH.

Molecules. 2018 Dec 12;23(12). pii: E3301. doi: 10.3390/molecules23123301.


Lichen Xanthones as Models for New Antifungal Agents.

Resende DISP, Pereira-Terra P, Inácio ÂS, Costa PMD, Pinto E, Sousa E, Pinto MMM.

Molecules. 2018 Oct 12;23(10). pii: E2617. doi: 10.3390/molecules23102617.


Chemistry of the fumiquinazolines and structurally related alkaloids.

Resende DISP, Boonpothong P, Sousa E, Kijjoa A, Pinto MMM.

Nat Prod Rep. 2019 Jan 1;36(1):7-34. doi: 10.1039/c8np00043c. Epub 2018 Aug 9.


Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products.

Long S, Resende DISP, Kijjoa A, Silva AMS, Pina A, Fernández-Marcelo T, Vasconcelos MH, Sousa E, Pinto MMM.

Mar Drugs. 2018 Jul 31;16(8). pii: E261. doi: 10.3390/md16080261.


Old Drugs as New Treatments for Neurodegenerative Diseases.

Durães F, Pinto M, Sousa E.

Pharmaceuticals (Basel). 2018 May 11;11(2). pii: E44. doi: 10.3390/ph11020044. Review.


Synthesis of New Glycosylated Flavonoids with Inhibitory Activity on Cell Growth.

Neves AR, Correia-da-Silva M, Silva PMA, Ribeiro D, Sousa E, Bousbaa H, Pinto M.

Molecules. 2018 May 5;23(5). pii: E1093. doi: 10.3390/molecules23051093.


Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives.

Urbatzka R, Freitas S, Palmeira A, Almeida T, Moreira J, Azevedo C, Afonso C, Correia-da-Silva M, Sousa E, Pinto M, Vasconcelos V.

Eur J Med Chem. 2018 May 10;151:272-284. doi: 10.1016/j.ejmech.2018.03.036. Epub 2018 Mar 23.


SULFATION PATHWAYS: Potential benefits of a sulfated resveratrol derivative for topical application.

Correia-da-Silva M, Rocha V, Marques C, Deus CM, Marques-Carvalho A, Oliveira PJ, Palmeira A, Pinto M, Sousa E, Sousa Lobo JM, Almeida IF.

J Mol Endocrinol. 2018 Aug;61(2):M27-M39. doi: 10.1530/JME-18-0031. Epub 2018 Mar 27.


Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies.

Lopes A, Martins E, Silva R, Pinto MMM, Remião F, Sousa E, Fernandes C.

Molecules. 2018 Mar 10;23(3). pii: E626. doi: 10.3390/molecules23030626.


A phytomodulatory hydrogel with enhanced healing effects.

Vasconcelos MS, Souza TFG, Figueiredo IS, Sousa ET, Sousa FD, Moreira RA, Alencar NMN, Lima-Filho JV, Ramos MV.

Phytother Res. 2018 Apr;32(4):688-697. doi: 10.1002/ptr.6018. Epub 2018 Feb 22.


Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators.

Durães F, Pinto M, Sousa E.

Curr Med Chem. 2018;25(42):6030-6069. doi: 10.2174/0929867325666180209142612. Review.


SULFATION PATHWAYS: Sources and biological activities of marine sulfated steroids.

Carvalhal F, Correia-da-Silva M, Sousa E, Pinto M, Kijjoa A.

J Mol Endocrinol. 2018 Aug;61(2):T211-T231. doi: 10.1530/JME-17-0252. Epub 2018 Jan 3. Review.


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