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Items: 11

1.

Potent In Vitro and In Vivo Anticancer Activity of New Bipyridine and Bipyrimidine Gold (III) Dithiocarbamate Derivatives.

Altaf M, Casagrande N, Mariotto E, Baig N, Kawde AN, Corona G, Larcher R, Borghese C, Pavan C, Seliman AA, Aldinucci D, Isab AA.

Cancers (Basel). 2019 Apr 4;11(4). pii: E474. doi: 10.3390/cancers11040474.

2.

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.

Romagnoli R, Prencipe F, Oliva P, Baraldi S, Baraldi PG, Schiaffino Ortega S, Chayah M, Kimatrai Salvador M, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Ronca R, Bortolozzi R, Mariotto E, Mattiuzzo E, Viola G.

J Med Chem. 2019 Feb 14;62(3):1274-1290. doi: 10.1021/acs.jmedchem.8b01391. Epub 2019 Jan 18.

PMID:
30633509
3.

Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer.

Mariotto E, Viola G, Ronca R, Persano L, Aveic S, Bhujwalla ZM, Mori N, Accordi B, Serafin V, López-Cara LC, Bortolozzi R.

Cancers (Basel). 2018 Oct 22;10(10). pii: E391. doi: 10.3390/cancers10100391.

4.

Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors.

Rubbini G, Buades-Martín AB, Kimatrai-Salvador M, Entrena A, Gallo-Mezo MÁ, Ríos-Marco P, Marco C, Mattiuzzo E, Bortolozzi R, Mariotto E, Greco FA, Macchiarulo A, Carrasco-Jiménez MP, Viola G, López-Cara LC.

Future Med Chem. 2018 Aug 1;10(15):1769-1786. doi: 10.4155/fmc-2018-0059. Epub 2018 Jul 25.

PMID:
30043647
5.

EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.

Mariotto E, Bortolozzi R, Volpin I, Carta D, Serafin V, Accordi B, Basso G, Navarro PL, López-Cara LC, Viola G.

Biochem Pharmacol. 2018 Sep;155:213-223. doi: 10.1016/j.bcp.2018.07.004. Epub 2018 Jul 11.

PMID:
30006194
6.

AKR1C enzymes sustain therapy resistance in paediatric T-ALL.

Bortolozzi R, Bresolin S, Rampazzo E, Paganin M, Maule F, Mariotto E, Boso D, Minuzzo S, Agnusdei V, Viola G, Te Kronnie G, Cazzaniga G, Basso G, Persano L.

Br J Cancer. 2018 Apr;118(7):985-994. doi: 10.1038/s41416-018-0014-0. Epub 2018 Mar 8.

7.

TP-0903 inhibits neuroblastoma cell growth and enhances the sensitivity to conventional chemotherapy.

Aveic S, Corallo D, Porcù E, Pantile M, Boso D, Zanon C, Viola G, Sidarovich V, Mariotto E, Quattrone A, Basso G, Tonini GP.

Eur J Pharmacol. 2018 Jan 5;818:435-448. doi: 10.1016/j.ejphar.2017.11.016. Epub 2017 Nov 14.

PMID:
29154838
8.

Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents.

Romagnoli R, Baraldi PG, Prencipe F, Oliva P, Baraldi S, Salvador MK, Lopez-Cara LC, Brancale A, Ferla S, Hamel E, Ronca R, Bortolozzi R, Mariotto E, Porcù E, Basso G, Viola G.

Sci Rep. 2017 Apr 13;7:46356. doi: 10.1038/srep46356.

9.

Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3',4',5'-Trimethoxyphenyl)-2-Aryl-1H-Imidazole.

Romagnoli R, Baraldi PG, Prencipe F, Oliva P, Baraldi S, Tabrizi MA, Lopez-Cara LC, Ferla S, Brancale A, Hamel E, Ronca R, Bortolozzi R, Mariotto E, Basso G, Viola G.

Sci Rep. 2016 May 24;6:26602. doi: 10.1038/srep26602.

10.

Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1).

Schiaffino-Ortega S, Baglioni E, Mariotto E, Bortolozzi R, Serrán-Aguilera L, Ríos-Marco P, Carrasco-Jimenez MP, Gallo MA, Hurtado-Guerrero R, Marco C, Basso G, Viola G, Entrena A, López-Cara LC.

Sci Rep. 2016 Mar 31;6:23793. doi: 10.1038/srep23793.

11.

New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1.

Castro-Navas FF, Schiaffino-Ortega S, Carrasco-Jimenez MP, Ríos-Marco P, Marco C, Espinosa A, Gallo MA, Mariotto E, Basso G, Viola G, Entrena-Guadix A, López-Cara LC.

Future Med Chem. 2015;7(4):417-36. doi: 10.4155/fmc.15.1.

PMID:
25875870

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