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Items: 13

1.

A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo.

Donald S, Elliott M, Gray B, Hornby F, Lewandowska A, Marlin S, Favre-Guilmard C, Périer C, Cornet S, Kalinichev M, Krupp J, Fonfria E.

Pharmacol Res Perspect. 2018 Nov 22;6(6):e00446. doi: 10.1002/prp2.446. eCollection 2018 Dec.

2.

Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity.

Fonfria E, Elliott M, Beard M, Chaddock JA, Krupp J.

Toxins (Basel). 2018 Jul 4;10(7). pii: E278. doi: 10.3390/toxins10070278. Review.

3.

The Expanding Therapeutic Utility of Botulinum Neurotoxins.

Fonfria E, Maignel J, Lezmi S, Martin V, Splevins A, Shubber S, Kalinichev M, Foster K, Picaut P, Krupp J.

Toxins (Basel). 2018 May 18;10(5). pii: E208. doi: 10.3390/toxins10050208. Review.

4.

Botulinum neurotoxin A and an engineered derivate targeted secretion inhibitor (TSI) A enter cells via different vesicular compartments.

Fonfria E, Donald S, Cadd VA.

J Recept Signal Transduct Res. 2016;36(1):79-88. doi: 10.3109/10799893.2015.1049359. Epub 2015 Aug 31.

PMID:
26329879
5.

Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.

Abberley L, Bebius A, Beswick PJ, Billinton A, Collis KL, Dean DK, Fonfria E, Gleave RJ, Medhurst SJ, Michel AD, Moses AP, Patel S, Roman SA, Scoccitti T, Smith B, Steadman JG, Walter DS.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6370-4. doi: 10.1016/j.bmcl.2010.09.101. Epub 2010 Sep 22.

PMID:
20934331
6.

Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.

Abdi MH, Beswick PJ, Billinton A, Chambers LJ, Charlton A, Collins SD, Collis KL, Dean DK, Fonfria E, Gleave RJ, Lejeune CL, Livermore DG, Medhurst SJ, Michel AD, Moses AP, Page L, Patel S, Roman SA, Senger S, Slingsby B, Steadman JG, Stevens AJ, Walter DS.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5080-4. doi: 10.1016/j.bmcl.2010.07.033. Epub 2010 Jul 14.

PMID:
20673717
7.

Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists.

Gleave RJ, Walter DS, Beswick PJ, Fonfria E, Michel AD, Roman SA, Tang SP.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4951-4. doi: 10.1016/j.bmcl.2010.05.018. Epub 2010 Jun 25.

PMID:
20634071
8.

Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.

Beswick PJ, Billinton A, Chambers LJ, Dean DK, Fonfria E, Gleave RJ, Medhurst SJ, Michel AD, Moses AP, Patel S, Roman SA, Roomans S, Senger S, Stevens AJ, Walter DS.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4653-6. doi: 10.1016/j.bmcl.2010.05.107. Epub 2010 Jun 8.

PMID:
20579878
9.

Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.

Chambers LJ, Stevens AJ, Moses AP, Michel AD, Walter DS, Davies DJ, Livermore DG, Fonfria E, Demont EH, Vimal M, Theobald PJ, Beswick PJ, Gleave RJ, Roman SA, Senger S.

Bioorg Med Chem Lett. 2010 May 15;20(10):3161-4. doi: 10.1016/j.bmcl.2010.03.096. Epub 2010 Mar 30.

PMID:
20399651
10.

TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia.

Fonfria E, Mattei C, Hill K, Brown JT, Randall A, Benham CD, Skaper SD, Campbell CA, Crook B, Murdock PR, Wilson JM, Maurio FP, Owen DE, Tilling PL, McNulty S.

J Recept Signal Transduct Res. 2006;26(3):179-98.

PMID:
16777714
11.

Tissue distribution profiles of the human TRPM cation channel family.

Fonfria E, Murdock PR, Cusdin FS, Benham CD, Kelsell RE, McNulty S.

J Recept Signal Transduct Res. 2006;26(3):159-78.

PMID:
16777713
12.

Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells.

Fonfría E, Vilaró MT, Babot Z, Rodríguez-Farré E, Suñol C.

J Neurosci Res. 2005 Feb 15;79(4):545-53.

PMID:
15635608
13.

TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase.

Fonfria E, Marshall IC, Benham CD, Boyfield I, Brown JD, Hill K, Hughes JP, Skaper SD, McNulty S.

Br J Pharmacol. 2004 Sep;143(1):186-92. Epub 2004 Aug 9.

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