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Items: 1 to 20 of 98

1.

Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro.

Cullia G, Bruno S, Parapini S, Margiotta M, Tamborini L, Pinto A, Galbiati A, Mozzarelli A, Persico M, Paladino A, Fattorusso C, Taramelli D, Conti P.

ACS Med Chem Lett. 2019 Feb 20;10(4):590-595. doi: 10.1021/acsmedchemlett.8b00592. eCollection 2019 Apr 11.

PMID:
30996801
2.

Malaria pigment accelerates MTT - formazan exocytosis in human endothelial cells.

D'Alessandro S, Corbett Y, Parapini S, Perego F, Cavicchini L, Signorini L, Delbue S, Perego C, Ferrante P, Taramelli D, Basilico N.

Parasitology. 2019 Mar;146(3):399-406. doi: 10.1017/S0031182018001579. Epub 2018 Oct 1.

PMID:
30269694
3.

Corrigendum to 'In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori' [International Journal of Antimicrobial Agents 48/1 (2016) 101-105].

Sisto F, Scaltrito MM, Masia C, Bonomi A, Coccè V, Marano G, Haynes RK, Miani A, Farronato G, Taramelli D.

Int J Antimicrob Agents. 2018 Oct;52(4):528. doi: 10.1016/j.ijantimicag.2018.08.006. Epub 2018 Aug 30. No abstract available.

PMID:
30172701
4.

Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities.

Wu Y, Parapini S, Williams ID, Misiano P, Wong HN, Taramelli D, Basilico N, Haynes RK.

Molecules. 2018 Jul 13;23(7). pii: E1713. doi: 10.3390/molecules23071713.

5.

Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.

Coertzen D, Reader J, van der Watt M, Nondaba SH, Gibhard L, Wiesner L, Smith P, D'Alessandro S, Taramelli D, Wong HN, du Preez JL, Wu RWK, Birkholtz LM, Haynes RK.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02214-17. doi: 10.1128/AAC.02214-17. Print 2018 Aug.

6.

Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.

Vallone A, D'Alessandro S, Brogi S, Brindisi M, Chemi G, Alfano G, Lamponi S, Lee SG, Jez JM, Koolen KJM, Dechering KJ, Saponara S, Fusi F, Gorelli B, Taramelli D, Parapini S, Caldelari R, Campiani G, Gemma S, Butini S.

Eur J Med Chem. 2018 Apr 25;150:698-718. doi: 10.1016/j.ejmech.2018.03.024. Epub 2018 Mar 10.

7.

HaCaT Cells as a Reliable In Vitro Differentiation Model to Dissect the Inflammatory/Repair Response of Human Keratinocytes.

Colombo I, Sangiovanni E, Maggio R, Mattozzi C, Zava S, Corbett Y, Fumagalli M, Carlino C, Corsetto PA, Scaccabarozzi D, Calvieri S, Gismondi A, Taramelli D, Dell'Agli M.

Mediators Inflamm. 2017;2017:7435621. doi: 10.1155/2017/7435621. Epub 2017 Dec 17.

8.

Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65.

Scaccabarozzi D, Deroost K, Corbett Y, Lays N, Corsetto P, Salè FO, Van den Steen PE, Taramelli D.

Malar J. 2018 Jan 9;17(1):18. doi: 10.1186/s12936-017-2159-3.

9.

In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial.

Basilico N, Parapini S, Sparatore A, Romeo S, Misiano P, Vivas L, Yardley V, Croft SL, Habluetzel A, Lucantoni L, Renia L, Russell B, Suwanarusk R, Nosten F, Dondio G, Bigogno C, Jabes D, Taramelli D.

Molecules. 2017 Dec 1;22(12). pii: E2102. doi: 10.3390/molecules22122102.

10.

Malaria pigment stimulates chemokine production by human microvascular endothelium.

Basilico N, Corbett Y, D' Alessandro S, Parapini S, Prato M, Girelli D, Misiano P, Olliaro P, Taramelli D.

Acta Trop. 2017 Aug;172:125-131. doi: 10.1016/j.actatropica.2017.05.002. Epub 2017 May 2.

PMID:
28476599
11.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

12.

In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori.

Sisto F, Scaltrito MM, Masia C, Bonomi A, Coccè V, Marano G, Haynes RK, Miani A, Farronato G, Taramelli D.

Int J Antimicrob Agents. 2016 Jul;48(1):101-105. doi: 10.1016/j.ijantimicag.2016.03.018. Epub 2016 May 6. Erratum in: Int J Antimicrob Agents. 2018 Oct;52(4):528.

PMID:
27216383
13.

A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays.

D'Alessandro S, Camarda G, Corbett Y, Siciliano G, Parapini S, Cevenini L, Michelini E, Roda A, Leroy D, Taramelli D, Alano P.

J Antimicrob Chemother. 2016 May;71(5):1148-58. doi: 10.1093/jac/dkv493. Epub 2016 Feb 16.

PMID:
26888912
14.

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Terzić N, Konstantinović J, Tot M, Burojević J, Djurković-Djaković O, Srbljanović J, Štajner T, Verbić T, Zlatović M, Machado M, Albuquerque IS, Prudêncio M, Sciotti RJ, Pecic S, D'Alessandro S, Taramelli D, Šolaja BA.

J Med Chem. 2016 Jan 14;59(1):264-81. doi: 10.1021/acs.jmedchem.5b01374. Epub 2015 Dec 18.

PMID:
26640981
15.

Altered Lipid Composition of Surfactant and Lung Tissue in Murine Experimental Malaria-Associated Acute Respiratory Distress Syndrome.

Scaccabarozzi D, Deroost K, Lays N, Omodeo Salè F, Van den Steen PE, Taramelli D.

PLoS One. 2015 Dec 1;10(12):e0143195. doi: 10.1371/journal.pone.0143195. eCollection 2015.

16.

Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains.

Tasso B, Novelli F, Tonelli M, Barteselli A, Basilico N, Parapini S, Taramelli D, Sparatore A, Sparatore F.

ChemMedChem. 2015 Sep;10(9):1570-83. doi: 10.1002/cmdc.201500195. Epub 2015 Jul 24.

PMID:
26213237
17.

Modified quaternary ammonium salts as potential antimalarial agents.

Basilico N, Migotto M, Ilboudo DP, Taramelli D, Stradi R, Pini E.

Bioorg Med Chem. 2015 Aug 1;23(15):4681-7. doi: 10.1016/j.bmc.2015.05.055. Epub 2015 Jun 3.

PMID:
26081764
18.

Salinomycin and other ionophores as a new class of antimalarial drugs with transmission-blocking activity.

D'Alessandro S, Corbett Y, Ilboudo DP, Misiano P, Dahiya N, Abay SM, Habluetzel A, Grande R, Gismondo MR, Dechering KJ, Koolen KM, Sauerwein RW, Taramelli D, Basilico N, Parapini S.

Antimicrob Agents Chemother. 2015 Sep;59(9):5135-44. doi: 10.1128/AAC.04332-14. Epub 2015 Jun 8.

19.

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission.

Ramdani G, Naissant B, Thompson E, Breil F, Lorthiois A, Dupuy F, Cummings R, Duffier Y, Corbett Y, Mercereau-Puijalon O, Vernick K, Taramelli D, Baker DA, Langsley G, Lavazec C.

PLoS Pathog. 2015 May 7;11(5):e1004815. doi: 10.1371/journal.ppat.1004815. eCollection 2015 May.

20.

Stability of the antimalarial drug dihydroartemisinin under physiologically relevant conditions: implications for clinical treatment and pharmacokinetic and in vitro assays.

Parapini S, Olliaro P, Navaratnam V, Taramelli D, Basilico N.

Antimicrob Agents Chemother. 2015 Jul;59(7):4046-52. doi: 10.1128/AAC.00183-15. Epub 2015 Apr 27.

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