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High Throughput. 2018 Dec 13;7(4). pii: E39. doi: 10.3390/ht7040039.

Precision Medicine in Pediatric Cancer: Current Applications and Future Prospects.

Author information

1
Departments of Pathology and Pediatric Hematology-Oncology, University of Missouri School of Medicine, Kansas City, MO 64108, USA. aahmed@cmh.edu.
2
Children's Mercy Hospital, Kansas City, MO 64108, USA. aahmed@cmh.edu.
3
Departments of Pathology and Pediatric Hematology-Oncology, University of Missouri School of Medicine, Kansas City, MO 64108, USA. dsvr5b@mail.umkc.edu.
4
Departments of Pathology and Pediatric Hematology-Oncology, University of Missouri School of Medicine, Kansas City, MO 64108, USA. msfarooqi@cmh.edu.
5
Children's Mercy Hospital, Kansas City, MO 64108, USA. msfarooqi@cmh.edu.
6
Departments of Pathology and Pediatric Hematology-Oncology, University of Missouri School of Medicine, Kansas City, MO 64108, USA. eguest@cmh.edu.
7
Children's Mercy Hospital, Kansas City, MO 64108, USA. eguest@cmh.edu.

Abstract

Precision oncologic medicine is an emerging approach for cancer treatment that has recently taken giant steps in solid clinical practice. Recent advances in molecular diagnostics that can analyze the individual tumor's variability in genes have provided greater understanding and additional strategies to treat cancers. Although tumors can be tested by several molecular methods, the use of next-generation sequencing (NGS) has greatly facilitated our understanding of pediatric cancer and identified additional therapeutic opportunities. Pediatric tumors have a different genetic make-up, with a fewer number of actionable targets than adult tumors. Nevertheless, precision oncology in the pediatric population has greatly improved the survival of patients with leukemia and solid tumors. This review discusses the current status of pediatric precision oncology and the different clinical scenarios in which it can be effectively applied.

KEYWORDS:

actionable mutations; next generation sequencing; pediatric cancer; precision medicine

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