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Items: 1 to 20 of 66


From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei.

Gonçalves TC, Benoit E, Kurz M, Lucarain L, Fouconnier S, Combemale S, Jaquillard L, Schombert B, Chambard JM, Boukaiba R, Hessler G, Bohme A, Bialy L, Hourcade S, Béroud R, De Waard M, Servent D, Partiseti M.

Br J Pharmacol. 2019 May;176(9):1298-1314. doi: 10.1111/bph.14628. Epub 2019 Apr 9.


Di- and heptavalent nicotinic analogues to interfere with α7 nicotinic acetylcholine receptors.

Brissonnet Y, Araoz R, Sousa R, Percevault L, Brument S, Deniaud D, Servent D, Le Questel JY, Lebreton J, Gouin SG.

Bioorg Med Chem. 2019 Mar 1;27(5):700-707. doi: 10.1016/j.bmc.2019.01.013. Epub 2019 Jan 17.


Aptamer Efficacies for In Vitro and In Vivo Modulation of αC-Conotoxin PrXA Pharmacology.

Taiwe GS, Montnach J, Nicolas S, De Waard S, Fiore E, Peyrin E, El-Aziz TMA, Amar M, Molgó J, Ronjat M, Servent D, Ravelet C, De Waard M.

Molecules. 2019 Jan 9;24(2). pii: E229. doi: 10.3390/molecules24020229.


Corrigendum: The NaV1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons.

Gonçalves TC, Benoit E, Partiseti M, Servent D.

Front Pharmacol. 2018 Oct 24;9:1241. doi: 10.3389/fphar.2018.01241. eCollection 2018.


The NaV1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons.

Gonçalves TC, Benoit E, Partiseti M, Servent D.

Front Pharmacol. 2018 Sep 4;9:1000. doi: 10.3389/fphar.2018.01000. eCollection 2018. Review. Erratum in: Front Pharmacol. 2018 Oct 24;9:1241.


Copper mediated amyloid-β binding to Transthyretin.

Ciccone L, Fruchart-Gaillard C, Mourier G, Savko M, Nencetti S, Orlandini E, Servent D, Stura EA, Shepard W.

Sci Rep. 2018 Sep 13;8(1):13744. doi: 10.1038/s41598-018-31808-5.


Prorocentrolide-A from Cultured Prorocentrum lima Dinoflagellates Collected in Japan Blocks Sub-Types of Nicotinic Acetylcholine Receptors.

Amar M, Aráoz R, Iorga BI, Yasumoto T, Servent D, Molgó J.

Toxins (Basel). 2018 Feb 28;10(3). pii: E97. doi: 10.3390/toxins10030097.


Direct evidence for high affinity blockade of NaV1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches.

Gonçalves TC, Boukaiba R, Molgó J, Amar M, Partiseti M, Servent D, Benoit E.

Neuropharmacology. 2018 May 1;133:404-414. doi: 10.1016/j.neuropharm.2018.02.016. Epub 2018 Feb 21.


RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia.

Christensen SB, Hone AJ, Roux I, Kniazeff J, Pin JP, Upert G, Servent D, Glowatzki E, McIntosh JM.

Front Cell Neurosci. 2017 Jul 21;11:219. doi: 10.3389/fncel.2017.00219. eCollection 2017.


Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides.

El-Aziz TMA, Ravelet C, Molgo J, Fiore E, Pale S, Amar M, Al-Khoury S, Dejeu J, Fadl M, Ronjat M, Taiwe GS, Servent D, Peyrin E, De Waard M.

Sci Rep. 2017 Aug 3;7(1):7202. doi: 10.1038/s41598-017-07554-5.


α9-containing nicotinic acetylcholine receptors and the modulation of pain.

Hone AJ, Servent D, McIntosh JM.

Br J Pharmacol. 2018 Jun;175(11):1915-1927. doi: 10.1111/bph.13931. Epub 2017 Jul 30. Review.


Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.

Ciolek J, Reinfrank H, Quinton L, Viengchareun S, Stura EA, Vera L, Sigismeau S, Mouillac B, Orcel H, Peigneur S, Tytgat J, Droctové L, Beau F, Nevoux J, Lombès M, Mourier G, De Pauw E, Servent D, Mendre C, Witzgall R, Gilles N.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7154-7159. doi: 10.1073/pnas.1620454114. Epub 2017 Jun 19.


Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins.

Blanchet G, Alili D, Protte A, Upert G, Gilles N, Tepshi L, Stura EA, Mourier G, Servent D.

Sci Rep. 2017 Jun 2;7(1):2701. doi: 10.1038/s41598-017-02953-0.


Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors.

Molgó J, Marchot P, Aráoz R, Benoit E, Iorga BI, Zakarian A, Taylor P, Bourne Y, Servent D.

J Neurochem. 2017 Aug;142 Suppl 2:41-51. doi: 10.1111/jnc.13995. Epub 2017 Mar 21. Review.


The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions.

Kessler P, Marchot P, Silva M, Servent D.

J Neurochem. 2017 Aug;142 Suppl 2:7-18. doi: 10.1111/jnc.13975. Epub 2017 Mar 21. Review.


Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry.

Echterbille J, Gilles N, Araóz R, Mourier G, Amar M, Servent D, De Pauw E, Quinton L.

Toxicon. 2017 May;130:1-10. doi: 10.1016/j.toxicon.2017.02.023. Epub 2017 Feb 24.


The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors.

Couesnon A, Aráoz R, Iorga BI, Benoit E, Reynaud M, Servent D, Molgó J.

Toxins (Basel). 2016 Aug 24;8(9). pii: E249. doi: 10.3390/toxins8090249.


Special Issue on "Toxins: New targets and new functions".

Benoit E, Barbier J, Popoff MR, Faure G, Molgó J, Servent D.

Toxicon. 2016 Jun 15;116:1-3. doi: 10.1016/j.toxicon.2016.03.012. Epub 2016 Mar 17. No abstract available.


Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.

Mourier G, Salinas M, Kessler P, Stura EA, Leblanc M, Tepshi L, Besson T, Diochot S, Baron A, Douguet D, Lingueglia E, Servent D.

J Biol Chem. 2016 Feb 5;291(6):2616-29. doi: 10.1074/jbc.M115.702373. Epub 2015 Dec 17.


The Neurotoxic Effect of 13,19-Didesmethyl and 13-Desmethyl Spirolide C Phycotoxins Is Mainly Mediated by Nicotinic Rather Than Muscarinic Acetylcholine Receptors.

Aráoz R, Ouanounou G, Iorga BI, Goudet A, Alili D, Amar M, Benoit E, Molgó J, Servent D.

Toxicol Sci. 2015 Sep;147(1):156-67. doi: 10.1093/toxsci/kfv119. Epub 2015 Jun 10.


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