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Items: 17

1.

Reduced T-cell Numbers and Elevated Levels of Immunomodulatory Cytokines in Metastatic Prostate Cancer Patients De Novo Resistant to Abiraterone and/or Enzalutamide Therapy.

Pal SK, Moreira D, Won H, White SW, Duttagupta P, Lucia M, Jones J, Hsu J, Kortylewski M.

Int J Mol Sci. 2019 Apr 13;20(8). pii: E1831. doi: 10.3390/ijms20081831.

2.

STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers.

Moreira D, Adamus T, Zhao X, Su YL, Zhang Z, White SV, Swiderski P, Lu X, DePinho RA, Pal SK, Kortylewski M.

Clin Cancer Res. 2018 Dec 1;24(23):5948-5962. doi: 10.1158/1078-0432.CCR-18-1277. Epub 2018 Oct 18.

PMID:
30337279
3.

B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors.

Zhao X, Zhang Z, Moreira D, Su YL, Won H, Adamus T, Dong Z, Liang Y, Yin HH, Swiderski P, Pillai RK, Kwak L, Forman S, Kortylewski M.

Mol Ther. 2018 Mar 7;26(3):695-707. doi: 10.1016/j.ymthe.2018.01.007. Epub 2018 Jan 17.

4.

TLR9 expression and secretion of LIF by prostate cancer cells stimulates accumulation and activity of polymorphonuclear MDSCs.

Won H, Moreira D, Gao C, Duttagupta P, Zhao X, Manuel E, Diamond D, Yuan YC, Liu Z, Jones J, D'Apuzzo M, Pal S, Kortylewski M.

J Leukoc Biol. 2017 Aug;102(2):423-436. doi: 10.1189/jlb.3MA1016-451RR. Epub 2017 May 22.

5.

Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities.

Kortylewski M, Moreira D.

Cancer Immunol Immunother. 2017 Aug;66(8):979-988. doi: 10.1007/s00262-017-1966-2. Epub 2017 Feb 18. Review.

6.

Using Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer Therapy.

Belizário JE, Sangiuliano BA, Perez-Sosa M, Neyra JM, Moreira DF.

Front Pharmacol. 2016 Sep 29;7:312. eCollection 2016. Review.

7.

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia.

Zhang Q, Hossain DM, Duttagupta P, Moreira D, Zhao X, Won H, Buettner R, Nechaev S, Majka M, Zhang B, Cai Q, Swiderski P, Kuo YH, Forman S, Marcucci G, Kortylewski M.

Blood. 2016 Mar 31;127(13):1687-700. doi: 10.1182/blood-2015-08-665604. Epub 2016 Jan 21.

8.

TLR9-Targeted SiRNA Delivery In Vivo.

Hossain DM, Moreira D, Zhang Q, Nechaev S, Swiderski P, Kortylewski M.

Methods Mol Biol. 2016;1364:183-96. doi: 10.1007/978-1-4939-3112-5_15.

9.

TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells.

Moreira D, Zhang Q, Hossain DM, Nechaev S, Li H, Kowolik CM, D'Apuzzo M, Forman S, Jones J, Pal SK, Kortylewski M.

Oncotarget. 2015 Jul 10;6(19):17302-13.

10.

TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients.

Hossain DM, Pal SK, Moreira D, Duttagupta P, Zhang Q, Won H, Jones J, D'Apuzzo M, Forman S, Kortylewski M.

Clin Cancer Res. 2015 Aug 15;21(16):3771-82. doi: 10.1158/1078-0432.CCR-14-3145. Epub 2015 May 12.

11.

Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling.

Bancovik J, Moreira DF, Carrasco D, Yao J, Porter D, Moura R, Camargo A, Fontes-Oliveira CC, Malpartida MG, Carambula S, Vannier E, Strauss BE, Wakamatsu A, Alves VA, Logullo AF, Soares FA, Polyak K, Belizário JE.

BMC Cancer. 2015 Feb 19;15:70. doi: 10.1186/s12885-015-1022-6.

12.

Cell death-associated molecular-pattern molecules: inflammatory signaling and control.

Sangiuliano B, Pérez NM, Moreira DF, Belizário JE.

Mediators Inflamm. 2014;2014:821043. doi: 10.1155/2014/821043. Epub 2014 Jul 21. Review.

13.

Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity.

Hossain DM, Dos Santos C, Zhang Q, Kozlowska A, Liu H, Gao C, Moreira D, Swiderski P, Jozwiak A, Kline J, Forman S, Bhatia R, Kuo YH, Kortylewski M.

Blood. 2014 Jan 2;123(1):15-25. doi: 10.1182/blood-2013-07-517987. Epub 2013 Oct 29.

14.

Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape.

Nechaev S, Gao C, Moreira D, Swiderski P, Jozwiak A, Kowolik CM, Zhou J, Armstrong B, Raubitschek A, Rossi JJ, Kortylewski M.

J Control Release. 2013 Sep 28;170(3):307-15. doi: 10.1016/j.jconrel.2013.06.007. Epub 2013 Jun 15.

15.

Bortezomib (PS-341) treatment decreases inflammation and partially rescues the expression of the dystrophin-glycoprotein complex in GRMD dogs.

Araujo KP, Bonuccelli G, Duarte CN, Gaiad TP, Moreira DF, Feder D, Belizario JE, Miglino MA, Lisanti MP, Ambrosio CE.

PLoS One. 2013 Apr 8;8(4):e61367. doi: 10.1371/journal.pone.0061367. Print 2013.

16.

Identification of a metallopeptidase with TOP-like activity in Paracoccidioides brasiliensis, with increased expression in a virulent strain.

Gravi ET, Paschoalin T, Dias BR, Moreira DF, Belizario JE, Oliveira V, Carmona AK, Juliano MA, Travassos LR, Rodrigues EG.

Med Mycol. 2012 Jan;50(1):81-90. doi: 10.3109/13693786.2011.590825. Epub 2011 Jul 5.

PMID:
21728754
17.

Role of SOCS-1 Gene on Melanoma Cell Growth and Tumor Development.

Scutti JA, Matsuo AL, Pereira FV, Massaoka MH, Figueiredo CR, Moreira DF, Belizário JE, Travassos LR.

Transl Oncol. 2011 Apr 1;4(2):101-9.

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