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Millisecond Timescale Motions Connect Amino Acid Interaction Networks in Alpha Tryptophan Synthase.

O'Rourke KF, Axe JM, D'Amico RN, Sahu D, Boehr DD.

Front Mol Biosci. 2018 Nov 8;5:92. doi: 10.3389/fmolb.2018.00092. eCollection 2018.


NMR Methods of Characterizing Biomolecular Structural Dynamics and Conformational Ensembles.

Boehr DD.

Methods. 2018 Sep 15;148:1-3. doi: 10.1016/j.ymeth.2018.08.011. No abstract available.


Assigning methyl resonances for protein solution-state NMR studies.

Gorman SD, Sahu D, O'Rourke KF, Boehr DD.

Methods. 2018 Sep 15;148:88-99. doi: 10.1016/j.ymeth.2018.06.010. Epub 2018 Jun 26.


Engineered control of enzyme structural dynamics and function.

Boehr DD, D'Amico RN, O'Rourke KF.

Protein Sci. 2018 Apr;27(4):825-838. doi: 10.1002/pro.3379. Epub 2018 Feb 16. Review.


The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain.

Shengjuler D, Chan YM, Sun S, Moustafa IM, Li ZL, Gohara DW, Buck M, Cremer PS, Boehr DD, Cameron CE.

Structure. 2017 Dec 5;25(12):1875-1886.e7. doi: 10.1016/j.str.2017.11.001.


Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases.

Yang X, Liu X, Musser DM, Moustafa IM, Arnold JJ, Cameron CE, Boehr DD.

J Biol Chem. 2017 Mar 3;292(9):3810-3826. doi: 10.1074/jbc.M116.750638. Epub 2017 Jan 18.


Biophysical and computational methods to analyze amino acid interaction networks in proteins.

O'Rourke KF, Gorman SD, Boehr DD.

Comput Struct Biotechnol J. 2016 Jun 22;14:245-51. doi: 10.1016/j.csbj.2016.06.002. eCollection 2016. Review.


Long-Range Communication between Different Functional Sites in the Picornaviral 3C Protein.

Chan YM, Moustafa IM, Arnold JJ, Cameron CE, Boehr DD.

Structure. 2016 Apr 5;24(4):509-517. doi: 10.1016/j.str.2016.02.019.


Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase.

Liu X, Musser DM, Lee CA, Yang X, Arnold JJ, Cameron CE, Boehr DD.

Viruses. 2015 Oct 26;7(10):5571-86. doi: 10.3390/v7102894.


The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ.

PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar.


Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.

Moustafa IM, Korboukh VK, Arnold JJ, Smidansky ED, Marcotte LL, Gohara DW, Yang X, Sánchez-Farrán MA, Filman D, Maranas JK, Boehr DD, Hogle JM, Colina CM, Cameron CE.

J Biol Chem. 2014 Dec 26;289(52):36229-48. doi: 10.1074/jbc.M114.616193. Epub 2014 Nov 6.


Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase.

Axe JM, O'Rourke KF, Kerstetter NE, Yezdimer EM, Chan YM, Chasin A, Boehr DD.

Protein Sci. 2015 Apr;24(4):484-94. doi: 10.1002/pro.2598. Epub 2014 Dec 11.


Targeting structural dynamics of the RNA-dependent RNA polymerase for anti-viral strategies.

Boehr DD, Liu X, Yang X.

Curr Opin Virol. 2014 Dec;9:194-200. doi: 10.1016/j.coviro.2014.08.006. Epub 2014 Sep 13. Review.


Amino acid networks in a (β/α)₈ barrel enzyme change during catalytic turnover.

Axe JM, Yezdimer EM, O'Rourke KF, Kerstetter NE, You W, Chang CE, Boehr DD.

J Am Chem Soc. 2014 May 14;136(19):6818-21. doi: 10.1021/ja501602t. Epub 2014 May 2.


Loop-loop interactions govern multiple steps in indole-3-glycerol phosphate synthase catalysis.

Zaccardi MJ, O'Rourke KF, Yezdimer EM, Loggia LJ, Woldt S, Boehr DD.

Protein Sci. 2014 Mar;23(3):302-11. doi: 10.1002/pro.2416. Epub 2014 Feb 4.


The ins and outs of viral RNA polymerase translocation.

Boehr DD.

J Mol Biol. 2014 Apr 3;426(7):1373-6. doi: 10.1016/j.jmb.2013.12.030. Epub 2014 Jan 3. No abstract available.


Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity.

Liu X, Yang X, Lee CA, Moustafa IM, Smidansky ED, Lum D, Arnold JJ, Cameron CE, Boehr DD.

J Biol Chem. 2013 Nov 8;288(45):32753-65. doi: 10.1074/jbc.M113.484428. Epub 2013 Sep 30.


Functional identification of the general acid and base in the dehydration step of indole-3-glycerol phosphate synthase catalysis.

Zaccardi MJ, Yezdimer EM, Boehr DD.

J Biol Chem. 2013 Sep 13;288(37):26350-6. doi: 10.1074/jbc.M113.487447. Epub 2013 Jul 30.


A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase.

Boehr DD, Schnell JR, McElheny D, Bae SH, Duggan BM, Benkovic SJ, Dyson HJ, Wright PE.

Biochemistry. 2013 Jul 9;52(27):4605-19. doi: 10.1021/bi400563c. Epub 2013 Jun 24.


Long-range interactions in the α subunit of tryptophan synthase help to coordinate ligand binding, catalysis, and substrate channeling.

Axe JM, Boehr DD.

J Mol Biol. 2013 May 13;425(9):1527-45. doi: 10.1016/j.jmb.2013.01.030. Epub 2013 Jan 30.


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