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Items: 1 to 20 of 85


Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.

Methot JL, Zhou H, Kattar SD, McGowan MA, Wilson K, Garcia Y, Deng Y, Altman M, Fradera X, Lesburg C, Fischmann T, Li C, Alves S, Shah S, Fernandez R, Goldenblatt P, Hill A, Shaffer L, Chen D, Tong V, McLeod RL, Yu H, Bass A, Kemper R, Gatto NT, LaFranco-Scheuch L, Trotter BW, Guzi T, Katz JD.

J Med Chem. 2019 May 9;62(9):4370-4382. doi: 10.1021/acs.jmedchem.8b01818. Epub 2019 Apr 22.


Saponins regulate intestinal inflammation in colon cancer and IBD.

Dong J, Liang W, Wang T, Sui J, Wang J, Deng Z, Chen D.

Pharmacol Res. 2019 Apr 5;144:66-72. doi: 10.1016/j.phrs.2019.04.010. [Epub ahead of print] Review.


Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy.

Tang Q, Cheng Z, Yang N, Li Q, Wang P, Chen D, Wang W, Song X, Dong X.

Biomaterials. 2019 Jun;205:1-10. doi: 10.1016/j.biomaterials.2019.03.005. Epub 2019 Mar 15.


Characterizing Pharmacokinetic-Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation.

McLeod RL, Gil MA, Chen D, Cabal A, Katz J, Methot J, Woodhouse JD, Dorosh L, Geda P, Mehta K, Cicmil M, Baltus GA, Bass A, Houshyar H, Caniga M, Yu H, Gervais F, Alves S, Shah S.

J Pharmacol Exp Ther. 2019 May;369(2):223-233. doi: 10.1124/jpet.118.252551. Epub 2019 Feb 25.


Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia.

Li Q, Li Y, Yi Q, Suo F, Tang Y, Luo S, Tian X, Zhang G, Chen D, Luo Z.

Eur J Clin Microbiol Infect Dis. 2019 Mar;38(3):457-465. doi: 10.1007/s10096-018-03443-5. Epub 2019 Jan 24.


Highly Sensitive Diode-Based Micro-Pirani Vacuum Sensor with Low Power Consumption.

Wei D, Fu J, Liu R, Hou Y, Liu C, Wang W, Chen D.

Sensors (Basel). 2019 Jan 7;19(1). pii: E188. doi: 10.3390/s19010188.


The landscape and diagnostic potential of T and B cell repertoire in Immunoglobulin A Nephropathy.

Huang C, Li X, Wu J, Zhang W, Sun S, Lin L, Wang X, Li H, Wu X, Zhang P, Xu G, Wang H, Liu H, Liu Y, Chen D, Zhuo L, Li W, Yang H, Wang J, Wang L, Liu X.

J Autoimmun. 2019 Feb;97:100-107. doi: 10.1016/j.jaut.2018.10.018. Epub 2018 Oct 29.


Top-down analysis of novel synthetic branched proteins.

Gomes F, Lemma B, Abeykoon D, Chen D, Wang Y, Fushman D, Fenselau C.

J Mass Spectrom. 2019 Jan;54(1):19-25. doi: 10.1002/jms.4303.


Tumor-Microenvironment-Responsive Nanoconjugate for Synergistic Antivascular Activity and Phototherapy.

Liang P, Huang X, Wang Y, Chen D, Ou C, Zhang Q, Shao J, Huang W, Dong X.

ACS Nano. 2018 Nov 27;12(11):11446-11457. doi: 10.1021/acsnano.8b06478. Epub 2018 Oct 22.


Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches.

Guo Y, Chu X, Parrott NJ, Brouwer KLR, Hsu V, Nagar S, Matsson P, Sharma P, Snoeys J, Sugiyama Y, Tatosian D, Unadkat JD, Huang SM, Galetin A; International Transporter Consortium.

Clin Pharmacol Ther. 2018 Nov;104(5):865-889. doi: 10.1002/cpt.1183. Epub 2018 Sep 12.


MH-Pen: A Pen-Type Multi-Mode Haptic Interface for Touch Screens Interaction.

Chen D, Song A, Tian L, Yu Y, Zhu L.

IEEE Trans Haptics. 2018 Oct-Dec;11(4):555-567. doi: 10.1109/TOH.2018.2826551. Epub 2018 Apr 13.


Rapid analysis of ricin using hot acid digestion and MALDI-TOF mass spectrometry.

Chen D, Bryden WA, Fenselau C.

J Mass Spectrom. 2018 Oct;53(10):1013-1017. doi: 10.1002/jms.4257. Epub 2018 Aug 15.


PBPK Modeling Strategy for Predicting Complex Drug Interactions of Letermovir as a Perpetrator in Support of Product Labeling.

Wang YH, Chen D, Hartmann G, Cho CR, Menzel K.

Clin Pharmacol Ther. 2019 Feb;105(2):515-523. doi: 10.1002/cpt.1120. Epub 2018 Sep 11.


IL-34 regulates IL-6 and IL-8 production in human lung fibroblasts via MAPK, PI3K-Akt, JAK and NF-κB signaling pathways.

Zhou J, Sun X, Zhang J, Yang Y, Chen D, Cao J.

Int Immunopharmacol. 2018 Aug;61:119-125. doi: 10.1016/j.intimp.2018.05.023. Epub 2018 May 30.


Photosensitizer synergistic effects: D-A-D structured organic molecule with enhanced fluorescence and singlet oxygen quantum yield for photodynamic therapy.

Zou J, Yin Z, Wang P, Chen D, Shao J, Zhang Q, Sun L, Huang W, Dong X.

Chem Sci. 2018 Jan 18;9(8):2188-2194. doi: 10.1039/c7sc04694d. eCollection 2018 Feb 28.


Top-Down Analysis of Branched Proteins Using Mass Spectrometry.

Chen D, Gomes F, Abeykoon D, Lemma B, Wang Y, Fushman D, Fenselau C.

Anal Chem. 2018 Mar 20;90(6):4032-4038. doi: 10.1021/acs.analchem.7b05234. Epub 2018 Mar 7.


Fortunellin-Induced Modulation of Phosphatase and Tensin Homolog by MicroRNA-374a Decreases Inflammation and Maintains Intestinal Barrier Function in Colitis.

Xiong Y, Qiu J, Li C, Qiu Y, Guo L, Liu Y, Wan J, Li Y, Wu G, Wang L, Zhou Z, Dong J, Du C, Chen D, Guo H.

Front Immunol. 2018 Jan 26;9:83. doi: 10.3389/fimmu.2018.00083. eCollection 2018.


pH-Responsive PEG-Doxorubicin-Encapsulated Aza-BODIPY Nanotheranostic Agent for Imaging-Guided Synergistic Cancer Therapy.

Chen D, Tang Q, Zou J, Yang X, Huang W, Zhang Q, Shao J, Dong X.

Adv Healthc Mater. 2018 Apr;7(7):e1701272. doi: 10.1002/adhm.201701272. Epub 2018 Jan 15.


Corrigendum: Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis.

Zhou Z, Wang L, Feng P, Yin L, Wang C, Zhi S, Dong J, Wang J, Lin Y, Chen D, Xiong Y, Peng J.

Front Immunol. 2017 Dec 13;8:1769. doi: 10.3389/fimmu.2017.01769. eCollection 2017.


Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis.

Zhou Z, Wang L, Feng P, Yin L, Wang C, Zhi S, Dong J, Wang J, Lin Y, Chen D, Xiong Y, Peng J.

Front Immunol. 2017 Nov 10;8:1468. doi: 10.3389/fimmu.2017.01468. eCollection 2017. Erratum in: Front Immunol. 2017 Dec 13;8:1769.

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