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Items: 1 to 20 of 95

1.

PAI-1 augments mucosal damage in colitis.

Kaiko GE, Chen F, Lai CW, Chiang IL, Perrigoue J, Stojmirović A, Li K, Muegge BD, Jain U, VanDussen KL, Goggins BJ, Keely S, Weaver J, Foster PS, Lawrence DA, Liu TC, Stappenbeck TS.

Sci Transl Med. 2019 Mar 6;11(482). pii: eaat0852. doi: 10.1126/scitranslmed.aat0852.

PMID:
30842312
2.

CpaA Is a Glycan-Specific Adamalysin-like Protease Secreted by Acinetobacter baumannii That Inactivates Coagulation Factor XII.

Waack U, Warnock M, Yee A, Huttinger Z, Smith S, Kumar A, Deroux A, Ginsburg D, Mobley HLT, Lawrence DA, Sandkvist M.

MBio. 2018 Dec 18;9(6). pii: e01606-18. doi: 10.1128/mBio.01606-18.

3.

Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate.

Reinke AA, Li SH, Warnock M, Shaydakov ME, Guntaka NS, Su EJ, Diaz JA, Emal CD, Lawrence DA.

J Biol Chem. 2019 Feb 1;294(5):1464-1477. doi: 10.1074/jbc.RA118.004885. Epub 2018 Dec 3.

PMID:
30510136
4.

Characterization of Tissue Plasminogen Activator Expression and Trafficking in the Adult Murine Brain.

Stevenson TK, Lawrence DA.

eNeuro. 2018 Aug 6;5(4). pii: ENEURO.0119-18.2018. doi: 10.1523/ENEURO.0119-18.2018. eCollection 2018 Jul-Aug.

5.

Update on the electrolytic IVC model for pre-clinical studies of venous thrombosis.

Palmer OR, Shaydakov ME, Rainey JP, Lawrence DA, Greve JM, Diaz JA.

Res Pract Thromb Haemost. 2018 Jan 31;2(2):266-273. doi: 10.1002/rth2.12074. eCollection 2018 Apr.

6.

Upregulation of P2Y2R, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome.

Bondu V, Bitting C, Poland VL, Hanson JA, Harkins MS, Lathrop S, Nolte KB, Lawrence DA, Buranda T.

Front Cell Infect Microbiol. 2018 May 23;8:169. doi: 10.3389/fcimb.2018.00169. eCollection 2018.

7.

Traumatic Brain Injury Leads to Accelerated Atherosclerosis in Apolipoprotein E Deficient Mice.

Wang J, Su E, Wang H, Guo C, Lawrence DA, Eitzman DT.

Sci Rep. 2018 Apr 4;8(1):5639. doi: 10.1038/s41598-018-23959-2.

8.

Plasminogen Activator Inhibitor-1 Reduces Tissue-Type Plasminogen Activator-Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose.

Pant A, Kopec AK, Baker KS, Cline-Fedewa H, Lawrence DA, Luyendyk JP.

Am J Pathol. 2018 May;188(5):1204-1212. doi: 10.1016/j.ajpath.2018.01.010. Epub 2018 Feb 16.

9.

Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo.

Bohannon KP, Bittner MA, Lawrence DA, Axelrod D, Holz RW.

J Gen Physiol. 2017 Oct 2;149(10):921-934. doi: 10.1085/jgp.201711842. Epub 2017 Sep 7.

10.

Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.

Su EJ, Cao C, Fredriksson L, Nilsson I, Stefanitsch C, Stevenson TK, Zhao J, Ragsdale M, Sun YY, Yepes M, Kuan CY, Eriksson U, Strickland DK, Lawrence DA, Zhang L.

Acta Neuropathol. 2017 Oct;134(4):585-604. doi: 10.1007/s00401-017-1749-z. Epub 2017 Jul 19.

11.

Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1.

Pautus S, Alami M, Adam F, Bernadat G, Lawrence DA, De Carvalho A, Ferry G, Rupin A, Hamze A, Champy P, Bonneau N, Gloanec P, Peglion JL, Brion JD, Bianchini EP, Borgel D.

Sci Rep. 2016 Nov 23;6:36462. doi: 10.1038/srep36462.

12.

Editorial: The Role of the Plasminogen Activating System in Neurobiology.

Medcalf RL, Lawrence DA.

Front Cell Neurosci. 2016 Oct 4;10:222. eCollection 2016. No abstract available.

13.

tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS.

Fredriksson L, Lawrence DA, Medcalf RL.

Semin Thromb Hemost. 2017 Mar;43(2):154-168. doi: 10.1055/s-0036-1586229. Epub 2016 Sep 27. Review.

14.

Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders.

Lewandowski SA, Fredriksson L, Lawrence DA, Eriksson U.

Pharmacol Ther. 2016 Nov;167:108-119. doi: 10.1016/j.pharmthera.2016.07.016. Epub 2016 Aug 12. Review.

15.

Neuroserpin Differentiates Between Forms of Tissue Type Plasminogen Activator via pH Dependent Deacylation.

Carlson KS, Nguyen L, Schwartz K, Lawrence DA, Schwartz BS.

Front Cell Neurosci. 2016 Jun 15;10:154. doi: 10.3389/fncel.2016.00154. eCollection 2016.

16.

Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.

Lewandowski SA, Nilsson I, Fredriksson L, Lönnerberg P, Muhl L, Zeitelhofer M, Adzemovic MZ, Nichterwitz S, Lawrence DA, Hedlund E, Eriksson U.

Acta Neuropathol. 2016 Mar;131(3):453-64. doi: 10.1007/s00401-015-1520-2. Epub 2015 Dec 19.

17.

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

Motley MP, Madsen DH, Jürgensen HJ, Spencer DE, Szabo R, Holmbeck K, Flick MJ, Lawrence DA, Castellino FJ, Weigert R, Bugge TH.

Blood. 2016 Mar 3;127(9):1085-96. doi: 10.1182/blood-2015-05-644260. Epub 2015 Dec 8.

18.

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury.

Su EJ, Fredriksson L, Kanzawa M, Moore S, Folestad E, Stevenson TK, Nilsson I, Sashindranath M, Schielke GP, Warnock M, Ragsdale M, Mann K, Lawrence AL, Medcalf RL, Eriksson U, Murphy GG, Lawrence DA.

Front Cell Neurosci. 2015 Oct 7;9:385. doi: 10.3389/fncel.2015.00385. eCollection 2015.

19.

Identification of a neurovascular signaling pathway regulating seizures in mice.

Fredriksson L, Stevenson TK, Su EJ, Ragsdale M, Moore S, Craciun S, Schielke GP, Murphy GG, Lawrence DA.

Ann Clin Transl Neurol. 2015 Jul;2(7):722-38. doi: 10.1002/acn3.209. Epub 2015 May 1.

20.

Elevated cytokines, thrombin and PAI-1 in severe HCPS patients due to Sin Nombre virus.

Bondu V, Schrader R, Gawinowicz MA, McGuire P, Lawrence DA, Hjelle B, Buranda T.

Viruses. 2015 Feb 10;7(2):559-89. doi: 10.3390/v7020559.

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