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Int J Infect Dis. 2018 Sep;74:47-53. doi: 10.1016/j.ijid.2018.06.023. Epub 2018 Jul 6.

Clinical characteristics and etiology of bacterial meningitis in Chinese children >28 days of age, January 2014-December 2016: A multicenter retrospective study.

Author information

1
Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China, Beijing, China; Department of Infectious Diseases, Shenzhen Children's Hospital, Shenzhen, China.
2
Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China, Beijing, China.
3
Department of Infectious Diseases, Qilu Children's Hospital of Shandong University, Jinan, China.
4
Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, China.
5
Department of Infectious Diseases, Kunming Children's Hospital, Kunming Medical University, Kunming, China.
6
Department of Pediatric, Affiliated Xingtai People's Hospital of Hebei Medical University, Xingtai, China.
7
Department of Pediatric Neurology, Jiangxi Provincial Children's Hospital, Nanchang, China.
8
Department of Infectious Diseases, Baoding Children's Hospital, Hebei Medical University, Baoding, China.
9
Department of No. 3 Pediatric Internal, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
10
Department of Children's Diseases, Daming County People's Hospital, Handan, China.
11
Pediatric Intensive Care Unit, Bao'an Maternity and Child Health Hospital, Shenzhen, China.
12
Department of Pediatric, Liaocheng People's Hospital, Liaocheng, China.
13
Department of Infectious Diseases, Shenzhen Children's Hospital, Shenzhen, China.
14
BGI Genomics Co., Ltd., Shenzhen, China.
15
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China, Beijing, China.
16
Department of Pediatric, Liaocheng People's Hospital, Liaocheng, China. Electronic address: sdlcyqz001@163.com.
17
Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China, Beijing, China. Electronic address: liugangbch@sina.com.

Abstract

OBJECTIVE:

To explore the clinical characteristics and etiology of bacterial meningitis (BM) in Chinese children.

METHOD:

BM cases in children 28days to 18 years old were collected from January 2014-December 2016 and screened according to World Health Organization standards. Clinical features, pathogens, and resistance patterns were analyzed.

RESULTS:

Overall, 837 cases were classified into five age groups: 28 days-2 months (17.0%), 3-11 months (27.8%), 12-35 months (24.0%), 3-6 years (13.9%), and >6years (17.3%). Major pathogens were Streptococcus pneumoniae (S. pneumoniae, n=136, 46.9%), group B Streptococcus (GBS, n=29, 10.0%), and Escherichia coli (E. coli, n=23, 7.9%). In infants <3 months old, GBS (46.5%) and E. coli (23.3%) were most common; in children >3 months old, S. pneumoniae (54.7%), which had a penicillin non-susceptibility rate of 55.4% (36/65), was most frequent. The resistance rates of S. pneumoniae and E. coli to cefotaxime and ceftriaxone were 14.0%/40.0% and 11.3%/68.4%, respectively. All GBS isolates were sensitive to penicillin.

CONCLUSIONS:

The occurrence of BM peaked in the first year of life, while S. pneumoniae was the predominant pathogen in children >3months of old. The antibiotic resistance of S. pneumoniae was a concern.

KEYWORDS:

Antibiotic susceptibility; Bacterial meningitis; Children; Pathogen

PMID:
30100536
DOI:
10.1016/j.ijid.2018.06.023
[Indexed for MEDLINE]
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