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Items: 1 to 20 of 112

1.

Second-Generation Tryptamine Derivatives Potently Sensitize Colistin Resistant Bacteria to Colistin.

Minrovic BM, Hubble VB, Barker WT, Jania LA, Melander RJ, Koller BH, Melander C.

ACS Med Chem Lett. 2019 Apr 17;10(5):828-833. doi: 10.1021/acsmedchemlett.9b00135. eCollection 2019 May 9.

PMID:
31098007
2.

Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation.

Nguyen TV, Peszko MT, Melander RJ, Melander C.

Medchemcomm. 2019 Feb 12;10(3):456-459. doi: 10.1039/c9md00025a. eCollection 2019 Mar 1.

PMID:
31015909
3.

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii.

Martin SE, Melander RJ, Brackett CM, Scott AJ, Chandler CE, Nguyen CM, Minrovic BM, Harrill SE, Ernst RK, Manoil C, Melander C.

ACS Infect Dis. 2019 Apr 26. doi: 10.1021/acsinfecdis.9b00067. [Epub ahead of print]

PMID:
31002491
4.

Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria.

Barker WT, Chandler CE, Melander RJ, Ernst RK, Melander C.

Bioorg Med Chem. 2019 May 1;27(9):1776-1788. doi: 10.1016/j.bmc.2019.03.019. Epub 2019 Mar 8.

PMID:
30898435
5.

Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold.

Nguyen TV, Minrovic BM, Melander RJ, Melander C.

ChemMedChem. 2019 May 6;14(9):927-937. doi: 10.1002/cmdc.201900033. Epub 2019 Mar 21.

PMID:
30834698
6.

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain.

Jeon AB, Ackart DF, Li W, Jackson M, Melander RJ, Melander C, Abramovitch RB, Chicco AJ, Basaraba RJ, Obregón-Henao A.

Sci Rep. 2019 Feb 6;9(1):1513. doi: 10.1038/s41598-018-38064-7.

7.

Electrochemical Detection of Small Molecule Induced Pseudomonas aeruginosa Biofilm Dispersion.

Robb AJ, Vinogradov S, Danell AS, Anderson E, Blackledge MS, Melander C, Hvastkovs EG.

Electrochim Acta. 2018 Apr 1;268:276-282. doi: 10.1016/j.electacta.2018.02.113. Epub 2018 Mar 2.

8.

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa.

Hubble VB, Hubbard BA, Minrovic BM, Melander RJ, Melander C.

ACS Infect Dis. 2019 Jan 11;5(1):141-151. doi: 10.1021/acsinfecdis.8b00288. Epub 2018 Nov 29.

PMID:
30444345
9.

2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium.

Huggins WM, Vu Nguyen T, Hahn NA, Baker JT, Kuo LG, Kaur D, Melander RJ, Gunn JS, Melander C.

Medchemcomm. 2018 Aug 2;9(9):1547-1552. doi: 10.1039/c8md00298c. eCollection 2018 Sep 1.

PMID:
30288228
10.

Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria.

Huggins WM, Barker WT, Baker JT, Hahn NA, Melander RJ, Melander C.

ACS Med Chem Lett. 2018 May 25;9(7):702-707. doi: 10.1021/acsmedchemlett.8b00161. eCollection 2018 Jul 12.

PMID:
30034604
11.

New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii.

Minrovic BM, Jung D, Melander RJ, Melander C.

ACS Infect Dis. 2018 Sep 14;4(9):1368-1376. doi: 10.1021/acsinfecdis.8b00103. Epub 2018 Jun 25.

PMID:
29890069
12.

Analogue synthesis reveals decoupling of antibiofilm and β-lactam potentiation activities of a lead 2-aminoimidazole adjuvant against Mycobacterium smegmatis.

Martin SE, Nguyen CM, Basaraba RJ, Melander C.

Chem Biol Drug Des. 2018 Aug;92(2):1403-1408. doi: 10.1111/cbdd.13208. Epub 2018 May 12.

PMID:
29663670
13.

Narrow-Spectrum Antibacterial Agents.

Melander RJ, Zurawski DV, Melander C.

Medchemcomm. 2018;9:12-21. doi: 10.1039/C7MD00528H. Epub 2017 Nov 6.

14.

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

Milton ME, Minrovic BM, Harris DL, Kang B, Jung D, Lewis CP, Thompson RJ, Melander RJ, Zeng D, Melander C, Cavanagh J.

Front Mol Biosci. 2018 Feb 13;5:15. doi: 10.3389/fmolb.2018.00015. eCollection 2018.

15.

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria.

Barker WT, Martin SE, Chandler CE, Nguyen TV, Harris TL, Goodell C, Melander RJ, Doi Y, Ernst RK, Melander C.

Bioorg Med Chem. 2017 Oct 15;25(20):5749-5753. doi: 10.1016/j.bmc.2017.08.055. Epub 2017 Sep 9.

16.

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds.

Milton ME, Allen CL, Feldmann EA, Bobay BG, Jung DK, Stephens MD, Melander RJ, Theisen KE, Zeng D, Thompson RJ, Melander C, Cavanagh J.

Mol Microbiol. 2017 Oct;106(2):223-235. doi: 10.1111/mmi.13759. Epub 2017 Aug 16.

17.

2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

Jeon AB, Obregón-Henao A, Ackart DF, Podell BK, Belardinelli JM, Jackson M, Nguyen TV, Blackledge MS, Melander RJ, Melander C, Johnson BK, Abramovitch RB, Basaraba RJ.

PLoS One. 2017 Jul 27;12(7):e0180925. doi: 10.1371/journal.pone.0180925. eCollection 2017.

18.

Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display.

Byrne-Nash R, Lucero DM, Osbaugh NA, Melander RJ, Melander C, Feldheim DL.

Bioconjug Chem. 2017 Jul 19;28(7):1807-1810. doi: 10.1021/acs.bioconjchem.7b00199. Epub 2017 Jun 27.

19.

The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

Melander RJ, Melander C.

ACS Infect Dis. 2017 Aug 11;3(8):559-563. doi: 10.1021/acsinfecdis.7b00071. Epub 2017 May 26.

20.

The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.

Nguyen TV, Blackledge MS, Lindsey EA, Minrovic BM, Ackart DF, Jeon AB, Obregón-Henao A, Melander RJ, Basaraba RJ, Melander C.

Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3940-3944. doi: 10.1002/anie.201612006. Epub 2017 Mar 1.

PMID:
28247991

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