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Items: 1 to 20 of 64

1.

Targeting Wnt Signaling via Notch in Intestinal Carcinogenesis.

Kaemmerer E, Jeon MK, Berndt A, Liedtke C, Gassler N.

Cancers (Basel). 2019 Apr 18;11(4). pii: E555. doi: 10.3390/cancers11040555. Review.

2.

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis.

Liao L, Schneider KM, Galvez EJC, Frissen M, Marschall HU, Su H, Hatting M, Wahlström A, Haybaeck J, Puchas P, Mohs A, Peng J, Bergheim I, Nier A, Hennings J, Reißing J, Zimmermann HW, Longerich T, Strowig T, Liedtke C, Cubero FJ, Trautwein C.

Gut. 2019 Mar 14. pii: gutjnl-2018-316670. doi: 10.1136/gutjnl-2018-316670. [Epub ahead of print]

PMID:
30872395
3.

Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma.

Sonntag R, Giebeler N, Nevzorova YA, Bangen JM, Fahrenkamp D, Lambertz D, Haas U, Hu W, Gassler N, Cubero FJ, Müller-Newen G, Abdallah AT, Weiskirchen R, Ticconi F, Costa IG, Barbacid M, Trautwein C, Liedtke C.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9282-9287. doi: 10.1073/pnas.1807155115. Epub 2018 Aug 27.

4.

Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis.

Cubero FJ, Peng J, Liao L, Su H, Zhao G, Zoubek ME, Macías-Rodríguez R, Ruiz-Margain A, Reißing J, Zimmermann HW, Gassler N, Luedde T, Liedtke C, Hatting M, Trautwein C.

J Hepatol. 2018 Dec;69(6):1326-1334. doi: 10.1016/j.jhep.2018.08.015. Epub 2018 Aug 23.

PMID:
30144553
5.

Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in a mouse model of chronic liver injury.

Ehedego H, Mohs A, Jansen B, Hiththetiya K, Sicinski P, Liedtke C, Trautwein C.

Oncogene. 2018 Jun;37(25):3329-3339. doi: 10.1038/s41388-018-0181-8. Epub 2018 Mar 19.

6.

Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice.

Hao F, Cubero FJ, Ramadori P, Liao L, Haas U, Lambertz D, Sonntag R, Bangen JM, Gassler N, Hoss M, Streetz KL, Reissing J, Zimmermann HW, Trautwein C, Liedtke C, Nevzorova YA.

Cell Death Dis. 2017 Oct 26;8(10):e3152. doi: 10.1038/cddis.2017.532.

7.

Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame.

Ramadori P, Cubero FJ, Liedtke C, Trautwein C, Nevzorova YA.

Cancers (Basel). 2017 Sep 25;9(10). pii: E130. doi: 10.3390/cancers9100130. Review.

8.

Targeting CCl4 -induced liver fibrosis by RNA interference-mediated inhibition of cyclin E1 in mice.

Bangen JM, Hammerich L, Sonntag R, Baues M, Haas U, Lambertz D, Longerich T, Lammers T, Tacke F, Trautwein C, Liedtke C.

Hepatology. 2017 Oct;66(4):1242-1257. doi: 10.1002/hep.29275. Epub 2017 Aug 26.

PMID:
28520165
9.

The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury.

Sevelsted Møller L, Fialla AD, Schierwagen R, Biagini M, Liedtke C, Laleman W, Klein S, Reul W, Koch Hansen L, Rabjerg M, Singh V, Surra J, Osada J, Reinehr R, de Muckadell OB, Köhler R, Trebicka J.

Sci Rep. 2016 Jun 29;6:28770. doi: 10.1038/srep28770.

10.

Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease.

Guldiken N, Kobazi Ensari G, Lahiri P, Couchy G, Preisinger C, Liedtke C, Zimmermann HW, Ziol M, Boor P, Zucman-Rossi J, Trautwein C, Strnad P.

J Hepatol. 2016 Sep;65(3):552-9. doi: 10.1016/j.jhep.2016.04.024. Epub 2016 May 2.

PMID:
27151178
11.

Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.

Cubero FJ, Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, Liedtke C, Trautwein C.

Gastroenterology. 2016 Apr;150(4):968-81. doi: 10.1053/j.gastro.2015.12.019. Epub 2015 Dec 19.

12.

Enhanced expression of c-myc in hepatocytes promotes initiation and progression of alcoholic liver disease.

Nevzorova YA, Cubero FJ, Hu W, Hao F, Haas U, Ramadori P, Gassler N, Hoss M, Strnad P, Zimmermann HW, Tacke F, Trautwein C, Liedtke C.

J Hepatol. 2016 Mar;64(3):628-40. doi: 10.1016/j.jhep.2015.11.005. Epub 2015 Nov 11.

PMID:
26576483
13.

Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes.

Kaemmerer E, Kuhn P, Schneider U, Jeon MK, Klaus C, Schiffer M, Weisner D, Liedtke C, Jäkel J, Kennes LN, Hilgers RD, Wagner N, Gassler N.

World J Gastroenterol. 2015 Apr 21;21(15):4499-508. doi: 10.3748/wjg.v21.i15.4499.

14.

NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes.

Boaru SG, Borkham-Kamphorst E, Van de Leur E, Lehnen E, Liedtke C, Weiskirchen R.

Biochem Biophys Res Commun. 2015 Mar 13;458(3):700-706. doi: 10.1016/j.bbrc.2015.02.029. Epub 2015 Feb 14.

PMID:
25686493
15.

p21 ablation in liver enhances DNA damage, cholestasis, and carcinogenesis.

Ehedego H, Boekschoten MV, Hu W, Doler C, Haybaeck J, Gaβler N, Müller M, Liedtke C, Trautwein C.

Cancer Res. 2015 Mar 15;75(6):1144-55. doi: 10.1158/0008-5472.CAN-14-1356. Epub 2015 Jan 21.

16.

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess.

Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ.

J Hepatol. 2015 May;62(5):1156-63. doi: 10.1016/j.jhep.2014.11.033. Epub 2014 Nov 28.

17.

Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury.

Cubero FJ, Zhao G, Nevzorova YA, Hatting M, Al Masaoudi M, Verdier J, Peng J, Schaefer FM, Hermanns N, Boekschoten MV, Grouls C, Gassler N, Kiessling F, Muller M, Davis RJ, Liedtke C, Trautwein C.

J Hepatol. 2015 Jan;62(1):140-9. doi: 10.1016/j.jhep.2014.08.029. Epub 2014 Aug 27.

PMID:
25173965
18.

Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver.

Asimakopoulou A, Borkham-Kamphorst E, Henning M, Yagmur E, Gassler N, Liedtke C, Berger T, Mak TW, Weiskirchen R.

Biochim Biophys Acta. 2014 Oct;1842(10):1513-24. doi: 10.1016/j.bbalip.2014.07.017. Epub 2014 Jul 31.

PMID:
25086218
19.

Hepatic tissue environment in NEMO-deficient mice critically regulates positive selection of donor cells after hepatocyte transplantation.

Kaldenbach M, Cubero FJ, Erschfeld S, Liedtke C, Trautwein C, Streetz K.

PLoS One. 2014 Jun 30;9(6):e100786. doi: 10.1371/journal.pone.0100786. eCollection 2014.

20.

The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling.

Borkham-Kamphorst E, Schaffrath C, Van de Leur E, Haas U, Tihaa L, Meurer SK, Nevzorova YA, Liedtke C, Weiskirchen R.

Biochim Biophys Acta. 2014 May;1843(5):902-14. doi: 10.1016/j.bbamcr.2014.01.023. Epub 2014 Jan 31.

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