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Items: 12


In vitro and in silico approaches to unveil the mechanisms underlying the cytotoxic effect of juncunol on human hepatocarcinoma cells.

Rodrigues MJ, Vizetto-Duarte C, Gangadhar KN, Zengin G, Mollica A, Varela J, Barreira L, Custódio L.

Pharmacol Rep. 2018 Oct;70(5):896-899. doi: 10.1016/j.pharep.2018.02.001. Epub 2018 Feb 2.


Report of in vitro antileishmanial properties of Iberian macroalgae.

Bruno de Sousa C, Lago JHG, Macridachis J, Oliveira M, Brito L, Vizetto-Duarte C, Florindo C, Hendrickx S, Maes L, Morais T, Uemi M, Neto L, Dionísio L, Cortes S, Barreira L, Custódio L, Alberício F, Campino L, Varela J.

Nat Prod Res. 2018 Feb 9:1-5. doi: 10.1080/14786419.2018.1434637. [Epub ahead of print]


A first glance into the nutritional properties of the sea cucumber Parastichopus regalis from the Mediterranean Sea (SE Spain).

Roggatz CC, González-Wangüemert M, Pereira H, Vizetto-Duarte C, Rodrigues MJ, Barreira L, da Silva MM, Varela J, Custódio L.

Nat Prod Res. 2018 Jan;32(1):116-120. doi: 10.1080/14786419.2017.1331224. Epub 2017 May 19.


Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata.

Bruno de Sousa C, Gangadhar KN, Morais TR, Conserva GA, Vizetto-Duarte C, Pereira H, Laurenti MD, Campino L, Levy D, Uemi M, Barreira L, Custódio L, Passero LF, Lago JH, Varela J.

Exp Parasitol. 2017 Mar;174:1-9. doi: 10.1016/j.exppara.2017.01.002. Epub 2017 Jan 24.


Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage.

Vizetto-Duarte C, Custódio L, Gangadhar KN, Lago JH, Dias C, Matos AM, Neng N, Nogueira JM, Barreira L, Albericio F, Rauter AP, Varela J.

Phytomedicine. 2016 May 15;23(5):550-7. doi: 10.1016/j.phymed.2016.02.008. Epub 2016 Feb 26.


Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds.

Vizetto-Duarte C, Custódio L, Acosta G, Lago JH, Morais TR, Bruno de Sousa C, Gangadhar KN, Rodrigues MJ, Pereira H, Lima RT, Vasconcelos MH, Barreira L, Rauter AP, Albericio F, Varela J.

PeerJ. 2016 Feb 16;4:e1704. doi: 10.7717/peerj.1704. eCollection 2016.


Methanol extracts from Cystoseira tamariscifolia and Cystoseira nodicaulis are able to inhibit cholinesterases and protect a human dopaminergic cell line from hydrogen peroxide-induced cytotoxicity.

Custódio L, Silvestre L, Rocha MI, Rodrigues MJ, Vizetto-Duarte C, Pereira H, Barreira L, Varela J.

Pharm Biol. 2016 Sep;54(9):1687-96. doi: 10.3109/13880209.2015.1123278. Epub 2016 Jan 5.


A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal.

Custódio L, Laukaityte S, Engelen AH, Rodrigues MJ, Pereira H, Vizetto-Duarte C, Barreira L, Rodríguez H, Alberício F, Varela J.

Nat Prod Res. 2016;30(6):724-8. doi: 10.1080/14786419.2015.1040791. Epub 2015 Jul 20.


Fatty acid profile of different species of algae of the Cystoseira genus: a nutraceutical perspective.

Vizetto-Duarte C, Pereira H, Bruno de Sousa C, Pilar Rauter A, Albericio F, Custódio L, Barreira L, Varela J.

Nat Prod Res. 2015;29(13):1264-70. doi: 10.1080/14786419.2014.992343. Epub 2015 Jan 2.


Maritime halophyte species from southern Portugal as sources of bioactive molecules.

Rodrigues MJ, Gangadhar KN, Vizetto-Duarte C, Wubshet SG, Nyberg NT, Barreira L, Varela J, Custódio L.

Mar Drugs. 2014 Apr 10;12(4):2228-44. doi: 10.3390/md12042228.


In vitro antitumoral activity of compounds isolated from Artemisia gorgonum Webb.

Martins A, Mignon R, Bastos M, Batista D, Neng NR, Nogueira JM, Vizetto-Duarte C, Custódio L, Varela J, Rauter AP.

Phytother Res. 2014 Sep;28(9):1329-34. doi: 10.1002/ptr.5133. Epub 2014 Mar 13.


Polyunsaturated Fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications.

Pereira H, Barreira L, Figueiredo F, Custódio L, Vizetto-Duarte C, Polo C, Rešek E, Engelen A, Varela J.

Mar Drugs. 2012 Sep;10(9):1920-35. doi: 10.3390/md10091920. Epub 2012 Aug 24.

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