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Items: 1 to 20 of 130

1.

A cationic polymethacrylate-copolymer acts as an agonist for ╬▓-amyloid and an antagonist for amylin fibrillation.

Sahoo BR, Genjo T, Nakayama TW, Stoddard AK, Ando T, Yasuhara K, Fierke CA, Ramamoorthy A.

Chem Sci. 2019 Feb 27;10(14):3976-3986. doi: 10.1039/c8sc05771k. eCollection 2019 Apr 14.

2.

Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.

Sahoo BR, Genjo T, Bekier M, Cox SJ, Stoddard AK, Ivanova M, Yasuhara K, Fierke CA, Wang Y, Ramamoorthy A.

Chem Commun (Camb). 2018 Nov 13;54(91):12883-12886. doi: 10.1039/c8cc07921h.

PMID:
30379172
3.

Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.

Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL 3rd, Fierke CA, Mapp AK.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8960-8965. doi: 10.1073/pnas.1806202115. Epub 2018 Aug 20.

4.

SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent.

Jennings BC, Lawton AJ, Rizk Z, Fierke CA.

Biochemistry. 2018 Jul 24;57(29):4289-4298. doi: 10.1021/acs.biochem.8b00567. Epub 2018 Jul 10.

PMID:
29940100
5.

Inner-Sphere Coordination of Divalent Metal Ion with Nucleobase in Catalytic RNA.

Liu X, Chen Y, Fierke CA.

J Am Chem Soc. 2017 Dec 6;139(48):17457-17463. doi: 10.1021/jacs.7b08755. Epub 2017 Nov 22.

6.

HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides.

Casta├▒eda CA, Wolfson NA, Leng KR, Kuo YM, Andrews AJ, Fierke CA.

J Biol Chem. 2017 Dec 29;292(52):21568-21577. doi: 10.1074/jbc.M117.811026. Epub 2017 Nov 6.

7.

HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking.

Lopez JE, Haynes SE, Majmudar JD, Martin BR, Fierke CA.

J Am Chem Soc. 2017 Nov 15;139(45):16222-16227. doi: 10.1021/jacs.7b07603. Epub 2017 Nov 1.

8.

Ion Mobility-Mass Spectrometry Reveals Evidence of Specific Complex Formation between Human Histone Deacetylase 8 and Poly-r(C)-binding Protein 1.

Niu S, Kim BC, Fierke CA, Ruotolo BT.

Int J Mass Spectrom. 2017 Sep;420:9-15. doi: 10.1016/j.ijms.2016.12.017. Epub 2016 Dec 15.

9.

Active Site Metal Identity Alters Histone Deacetylase 8 Substrate Selectivity: A Potential Novel Regulatory Mechanism.

Castaneda CA, Lopez JE, Joseph CG, Scholle MD, Mrksich M, Fierke CA.

Biochemistry. 2017 Oct 24;56(42):5663-5670. doi: 10.1021/acs.biochem.7b00851. Epub 2017 Oct 12.

10.

Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P.

Klemm BP, Karasik A, Kaitany KJ, Shanmuganathan A, Henley MJ, Thelen AZ, Dewar AJL, Jackson ND, Koutmos M, Fierke CA.

RNA. 2017 Dec;23(12):1860-1873. doi: 10.1261/rna.061457.117. Epub 2017 Sep 5.

11.

Preface.

Thompson RB, Fierke CA.

Methods Enzymol. 2017;589:xvii-xviii. doi: 10.1016/S0076-6879(17)30107-6. No abstract available.

PMID:
28336076
12.

Measuring and Imaging Metal Ions With Fluorescence-Based Biosensors: Speciation, Selectivity, Kinetics, and Other Issues.

Thompson RB, Fierke CA.

Methods Enzymol. 2017;589:281-299. doi: 10.1016/bs.mie.2017.01.003. Epub 2017 Mar 9.

PMID:
28336067
13.

Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues.

Temple KJ, Wright EN, Fierke CA, Gibbs RA.

Org Lett. 2016 Dec 2;18(23):6038-6041. Epub 2016 Nov 14.

14.

Fluorescence-Based Real-Time Activity Assays to Identify RNase P Inhibitors.

Chen Y, Liu X, Wu N, Fierke CA.

Methods Mol Biol. 2017;1520:201-225. doi: 10.1007/978-1-4939-6634-9_12.

PMID:
27873254
15.

Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.

Temple KJ, Wright EN, Fierke CA, Gibbs RA.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3503-7. doi: 10.1016/j.bmcl.2016.06.035. Epub 2016 Jun 15.

16.

Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.

Temple KJ, Wright EN, Fierke CA, Gibbs RA.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3499-502. doi: 10.1016/j.bmcl.2016.06.034. Epub 2016 Jun 16.

17.

The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases.

Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL.

J Biol Chem. 2016 May 13;291(20):10948. doi: 10.1074/jbc.A115.696831. No abstract available.

18.

The Diversity of Ribonuclease P: Protein and RNA Catalysts with Analogous Biological Functions.

Klemm BP, Wu N, Chen Y, Liu X, Kaitany KJ, Howard MJ, Fierke CA.

Biomolecules. 2016 May 13;6(2). pii: E27. doi: 10.3390/biom6020027. Review.

19.

Differential substrate recognition by isozymes of plant protein-only Ribonuclease P.

Howard MJ, Karasik A, Klemm BP, Mei C, Shanmuganathan A, Fierke CA, Koutmos M.

RNA. 2016 May;22(5):782-92. doi: 10.1261/rna.055541.115. Epub 2016 Mar 10.

20.

Structure-Based Identification of HDAC8 Non-histone Substrates.

Alam N, Zimmerman L, Wolfson NA, Joseph CG, Fierke CA, Schueler-Furman O.

Structure. 2016 Mar 1;24(3):458-68. doi: 10.1016/j.str.2016.02.002.

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