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Items: 1 to 20 of 46

1.

NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells-A Potential Target for Adjuvant Radiotherapy.

Müller-Längle A, Lutz H, Hehlgans S, Rödel F, Rau K, Laube B.

Cancers (Basel). 2019 Apr 9;11(4). pii: E503. doi: 10.3390/cancers11040503.

2.

NMDA Receptor Signaling Mediates cFos Expression via Top2β-Induced DSBs in Glioblastoma Cells.

Lutz H, Nguyen TA, Joswig J, Rau K, Laube B.

Cancers (Basel). 2019 Mar 5;11(3). pii: E306. doi: 10.3390/cancers11030306.

3.

Coupling of a viral K+-channel with a glutamate-binding-domain highlights the modular design of ionotropic glutamate-receptors.

Schönrock M, Thiel G, Laube B.

Commun Biol. 2019 Feb 22;2:75. doi: 10.1038/s42003-019-0320-y. eCollection 2019.

4.

Ligand binding domain interface: A tipping point for pharmacological agents binding with GluN1/2A subunit containing NMDA receptors.

Bledsoe D, Vacca B, Laube B, Klein BG, Costa B.

Eur J Pharmacol. 2019 Feb 5;844:216-224. doi: 10.1016/j.ejphar.2018.12.023. Epub 2018 Dec 13.

PMID:
30553788
5.

Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.

Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Müller UC.

EMBO J. 2018 Jun 1;37(11). pii: e98335. doi: 10.15252/embj.201798335. Epub 2018 Apr 16.

6.

Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity.

Bledsoe D, Tamer C, Mesic I, Madry C, Klein BG, Laube B, Costa BM.

Front Pharmacol. 2017 May 9;8:229. doi: 10.3389/fphar.2017.00229. eCollection 2017.

7.

GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects.

Platzer K, Yuan H, Schütz H, Winschel A, Chen W, Hu C, Kusumoto H, Heyne HO, Helbig KL, Tang S, Willing MC, Tinkle BT, Adams DJ, Depienne C, Keren B, Mignot C, Frengen E, Strømme P, Biskup S, Döcker D, Strom TM, Mefford HC, Myers CT, Muir AM, LaCroix A, Sadleir L, Scheffer IE, Brilstra E, van Haelst MM, van der Smagt JJ, Bok LA, Møller RS, Jensen UB, Millichap JJ, Berg AT, Goldberg EM, De Bie I, Fox S, Major P, Jones JR, Zackai EH, Abou Jamra R, Rolfs A, Leventer RJ, Lawson JA, Roscioli T, Jansen FE, Ranza E, Korff CM, Lehesjoki AE, Courage C, Linnankivi T, Smith DR, Stanley C, Mintz M, McKnight D, Decker A, Tan WH, Tarnopolsky MA, Brady LI, Wolff M, Dondit L, Pedro HF, Parisotto SE, Jones KL, Patel AD, Franz DN, Vanzo R, Marco E, Ranells JD, Di Donato N, Dobyns WB, Laube B, Traynelis SF, Lemke JR.

J Med Genet. 2017 Jul;54(7):460-470. doi: 10.1136/jmedgenet-2016-104509. Epub 2017 Apr 4.

8.

Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy.

Lemke JR, Geider K, Helbig KL, Heyne HO, Schütz H, Hentschel J, Courage C, Depienne C, Nava C, Heron D, Møller RS, Hjalgrim H, Lal D, Neubauer BA, Nürnberg P, Thiele H, Kurlemann G, Arnold GL, Bhambhani V, Bartholdi D, Pedurupillay CR, Misceo D, Frengen E, Strømme P, Dlugos DJ, Doherty ES, Bijlsma EK, Ruivenkamp CA, Hoffer MJ, Goldstein A, Rajan DS, Narayanan V, Ramsey K, Belnap N, Schrauwen I, Richholt R, Koeleman BP, Sá J, Mendonça C, de Kovel CG, Weckhuysen S, Hardies K, De Jonghe P, De Meirleir L, Milh M, Badens C, Lebrun M, Busa T, Francannet C, Piton A, Riesch E, Biskup S, Vogt H, Dorn T, Helbig I, Michaud JL, Laube B, Syrbe S.

Neurology. 2016 Jun 7;86(23):2171-8. doi: 10.1212/WNL.0000000000002740. Epub 2016 May 6.

9.

The N-terminal domain of the GluN3A subunit determines the efficacy of glycine-activated NMDA receptors.

Mesic I, Madry C, Geider K, Bernhard M, Betz H, Laube B.

Neuropharmacology. 2016 Jun;105:133-141. doi: 10.1016/j.neuropharm.2016.01.014. Epub 2016 Jan 9.

PMID:
26777280
10.

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.

Lynagh T, Beech RN, Lalande MJ, Keller K, Cromer BA, Wolstenholme AJ, Laube B.

Sci Rep. 2015 Feb 24;5:8558. doi: 10.1038/srep08558.

11.

Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics.

Lynagh T, Cromer BA, Dufour V, Laube B.

Int J Parasitol Drugs Drug Resist. 2014 Aug 10;4(3):244-55. doi: 10.1016/j.ijpddr.2014.07.004. eCollection 2014 Dec.

12.

Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site.

Lynagh T, Laube B.

J Neurosci. 2014 Feb 5;34(6):2155-9. doi: 10.1523/JNEUROSCI.4307-13.2014.

13.

GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy.

Lemke JR, Hendrickx R, Geider K, Laube B, Schwake M, Harvey RJ, James VM, Pepler A, Steiner I, Hörtnagel K, Neidhardt J, Ruf S, Wolff M, Bartholdi D, Caraballo R, Platzer K, Suls A, De Jonghe P, Biskup S, Weckhuysen S.

Ann Neurol. 2014 Jan;75(1):147-54. doi: 10.1002/ana.24073. Epub 2014 Jan 2.

14.

Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation.

Lynagh T, Kunz A, Laube B.

ACS Chem Neurosci. 2013 Nov 20;4(11):1469-78. doi: 10.1021/cn400134p. Epub 2013 Sep 17.

15.

Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.

Lemke JR, Lal D, Reinthaler EM, Steiner I, Nothnagel M, Alber M, Geider K, Laube B, Schwake M, Finsterwalder K, Franke A, Schilhabel M, Jähn JA, Muhle H, Boor R, Van Paesschen W, Caraballo R, Fejerman N, Weckhuysen S, De Jonghe P, Larsen J, Møller RS, Hjalgrim H, Addis L, Tang S, Hughes E, Pal DK, Veri K, Vaher U, Talvik T, Dimova P, Guerrero López R, Serratosa JM, Linnankivi T, Lehesjoki AE, Ruf S, Wolff M, Buerki S, Wohlrab G, Kroell J, Datta AN, Fiedler B, Kurlemann G, Kluger G, Hahn A, Haberlandt DE, Kutzer C, Sperner J, Becker F, Weber YG, Feucht M, Steinböck H, Neophythou B, Ronen GM, Gruber-Sedlmayr U, Geldner J, Harvey RJ, Hoffmann P, Herms S, Altmüller J, Toliat MR, Thiele H, Nürnberg P, Wilhelm C, Stephani U, Helbig I, Lerche H, Zimprich F, Neubauer BA, Biskup S, von Spiczak S.

Nat Genet. 2013 Sep;45(9):1067-72. doi: 10.1038/ng.2728. Epub 2013 Aug 11.

PMID:
23933819
16.

Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site.

Dutertre S, Drwal M, Laube B, Betz H.

J Neurochem. 2012 Jul;122(1):38-47. doi: 10.1111/j.1471-4159.2012.07755.x. Epub 2012 Apr 27.

17.

Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid.

Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Laube B, Jane DE, Monaghan DT.

Neuropharmacology. 2012 Mar;62(4):1730-6. doi: 10.1016/j.neuropharm.2011.11.019. Epub 2011 Dec 6.

18.

Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2.

Kallenborn-Gerhardt W, Lu R, Lorenz J, Gao W, Weiland J, Del Turco D, Deller T, Laube B, Betz H, Geisslinger G, Schmidtko A.

Behav Brain Res. 2012 Jan 1;226(1):106-11. doi: 10.1016/j.bbr.2011.09.002. Epub 2011 Sep 8.

PMID:
21924294
19.

Robust post-translocational N-glycosylation at the extreme C-terminus of membrane and secreted proteins in Xenopus laevis oocytes and HEK293 cells.

Pult F, Fallah G, Braam U, Detro-Dassen S, Niculescu C, Laube B, Schmalzing G.

Glycobiology. 2011 Sep;21(9):1147-60. doi: 10.1093/glycob/cwr013. Epub 2011 Feb 8.

PMID:
21303814
20.

Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.

Endele S, Rosenberger G, Geider K, Popp B, Tamer C, Stefanova I, Milh M, Kortüm F, Fritsch A, Pientka FK, Hellenbroich Y, Kalscheuer VM, Kohlhase J, Moog U, Rappold G, Rauch A, Ropers HH, von Spiczak S, Tönnies H, Villeneuve N, Villard L, Zabel B, Zenker M, Laube B, Reis A, Wieczorek D, Van Maldergem L, Kutsche K.

Nat Genet. 2010 Nov;42(11):1021-6. doi: 10.1038/ng.677. Epub 2010 Oct 3.

PMID:
20890276

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