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Items: 8


Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers.

Subramanian RR, Wysk MA, Ogilvie KM, Bhat A, Kuang B, Rockel TD, Weber M, Uhlmann E, Krieg AM.

Nucleic Acids Res. 2015 Oct 30;43(19):9123-32. doi: 10.1093/nar/gkv992. Epub 2015 Oct 7.


A mathematical model of the effect of immunogenicity on therapeutic protein pharmacokinetics.

Chen X, Hickling T, Kraynov E, Kuang B, Parng C, Vicini P.

AAPS J. 2013 Oct;15(4):1141-54. doi: 10.1208/s12248-013-9517-z. Epub 2013 Aug 30.


Modeling, simulation, and translation framework for the preclinical development of monoclonal antibodies.

Luu KT, Kraynov E, Kuang B, Vicini P, Zhong WZ.

AAPS J. 2013 Apr;15(2):551-8. doi: 10.1208/s12248-013-9464-8. Epub 2013 Feb 14. Review.


How current understanding of clearance mechanisms and pharmacodynamics of therapeutic proteins can be applied for evaluation of their drug-drug interaction potential.

Kraynov E, Martin SW, Hurst S, Fahmi OA, Dowty M, Cronenberger C, Loi CM, Kuang B, Fields O, Fountain S, Awwad M, Wang D.

Drug Metab Dispos. 2011 Oct;39(10):1779-83. doi: 10.1124/dmd.111.040808. Epub 2011 Jul 18. Review.


Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.

Ding JD, Johnson LV, Herrmann R, Farsiu S, Smith SG, Groelle M, Mace BE, Sullivan P, Jamison JA, Kelly U, Harrabi O, Bollini SS, Dilley J, Kobayashi D, Kuang B, Li W, Pons J, Lin JC, Bowes Rickman C.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):E279-87. doi: 10.1073/pnas.1100901108. Epub 2011 Jun 20.


Therapeutic monoclonal antibody concentration monitoring: free or total?

Kuang B, King L, Wang HF.

Bioanalysis. 2010 Jun;2(6):1125-40. doi: 10.4155/bio.10.64. Review.


CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.

Tse KF, Jeffers M, Pollack VA, McCabe DA, Shadish ML, Khramtsov NV, Hackett CS, Shenoy SG, Kuang B, Boldog FL, MacDougall JR, Rastelli L, Herrmann J, Gallo M, Gazit-Bornstein G, Senter PD, Meyer DL, Lichenstein HS, LaRochelle WJ.

Clin Cancer Res. 2006 Feb 15;12(4):1373-82.


A Drosophila protein-interaction map centered on cell-cycle regulators.

Stanyon CA, Liu G, Mangiola BA, Patel N, Giot L, Kuang B, Zhang H, Zhong J, Finley RL Jr.

Genome Biol. 2004;5(12):R96. Epub 2004 Nov 26.

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