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Items: 16

1.

Synthesis and pharmacological evaluation of functionalized isoindolinones on GABA-activated chloride currents in rat cerebellum granule cells in culture.

Di Mola A, Gatta E, Petronzi C, Cupello A, De Caprariis P, Robello M, Massa A, Filosa R.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5284-5289. doi: 10.1016/j.bmcl.2016.09.042. Epub 2016 Sep 15.

PMID:
27720293
2.

Bifunctional phase-transfer catalysis in the asymmetric synthesis of biologically active isoindolinones.

Di Mola A, Tiffner M, Scorzelli F, Palombi L, Filosa R, De Caprariis P, Waser M, Massa A.

Beilstein J Org Chem. 2015 Dec 15;11:2591-9. doi: 10.3762/bjoc.11.279. eCollection 2015.

3.

Isoindolinones as Michael Donors under Phase Transfer Catalysis: Enantioselective Synthesis of Phthalimidines Containing a Tetrasubstituted Carbon Stereocenter.

Scorzelli F, Di Mola A, Palombi L, Massa A.

Molecules. 2015 May 12;20(5):8484-98. doi: 10.3390/molecules20058484.

4.

Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication.

Di Mola A, Peduto A, La Gatta A, Delang L, Pastorino B, Neyts J, Leyssen P, de Rosa M, Filosa R.

Bioorg Med Chem. 2014 Nov 1;22(21):6014-25. doi: 10.1016/j.bmc.2014.09.013. Epub 2014 Sep 16.

PMID:
25282648
5.

Combined electrochemical/chemical methods for the synthesis and the molecular diversifying of isoindolinone-based heterocyclic scaffolds.

Palombi L, Di Mola A, Vignes C, Massa A.

Mol Divers. 2014 May;18(2):323-33. doi: 10.1007/s11030-013-9502-6. Epub 2014 Jan 12.

PMID:
24415224
6.

Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers.

Catalano A, Budriesi R, Bruno C, Di Mola A, Defrenza I, Cavalluzzi MM, Micucci M, Carocci A, Franchini C, Lentini G.

Eur J Med Chem. 2013 Jul;65:511-6. doi: 10.1016/j.ejmech.2013.05.008. Epub 2013 May 18.

PMID:
23777871
7.

Design of inhibitors of influenza virus membrane fusion: synthesis, structure-activity relationship and in vitro antiviral activity of a novel indole series.

Brancato V, Peduto A, Wharton S, Martin S, More V, Di Mola A, Massa A, Perfetto B, Donnarumma G, Schiraldi C, Tufano MA, de Rosa M, Filosa R, Hay A.

Antiviral Res. 2013 Aug;99(2):125-35. doi: 10.1016/j.antiviral.2013.05.005. Epub 2013 May 22.

PMID:
23707194
8.

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.

Catalano A, Desaphy JF, Lentini G, Carocci A, Di Mola A, Bruno C, Carbonara R, De Palma A, Budriesi R, Ghelardini C, Perrone MG, Colabufo NA, Conte Camerino D, Franchini C.

J Med Chem. 2012 Feb 9;55(3):1418-22. doi: 10.1021/jm201197z. Epub 2012 Jan 31.

PMID:
22191686
9.

Multi-component, regio-selective aldol addition of β-ketoesters to aldehydes: scope and applications.

More V, Di Mola A, Croce G, Tedesco C, Petronzi C, Peduto A, De Caprariis P, Filosa R, Massa A.

Org Biomol Chem. 2011 Dec 21;9(24):8483-8. doi: 10.1039/c1ob06229h. Epub 2011 Nov 3.

PMID:
22051978
10.

Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization.

Zakhari JS, Kinoyama I, Hixon MS, Di Mola A, Globisch D, Janda KD.

Bioorg Med Chem. 2011 Nov 1;19(21):6203-9. doi: 10.1016/j.bmc.2011.09.019. Epub 2011 Sep 14.

11.

1-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-pyrrolidine-2-carboxamide: investigation of structural variations.

Catalano A, Carocci A, Di Mola A, Bruno C, Vanderheyden PM, Franchini C.

Arch Pharm (Weinheim). 2011 Sep;344(9):617-26. doi: 10.1002/ardp.201000296. Epub 2011 Jun 28.

PMID:
21713967
12.

2,3-Dihydro-1,2-Diphenyl-substituted 4H-Pyridinone derivatives as new anti Flaviviridae inhibitors.

Peduto A, Massa A, Di Mola A, de Caprariis P, La Colla P, Loddo R, Altamura S, Maga G, Filosa R.

Chem Biol Drug Des. 2011 Jun;77(6):441-9. doi: 10.1111/j.1747-0285.2011.01102.x. Epub 2011 Mar 17.

PMID:
21414145
13.

Symptomatic relief of botulinum neurotoxin/a intoxication with aminopyridines: a new twist on an old molecule.

Mayorov AV, Willis B, Di Mola A, Adler D, Borgia J, Jackson O, Wang J, Luo Y, Tang L, Knapp RJ, Natarajan C, Goodnough MC, Zilberberg N, Simpson LL, Janda KD.

ACS Chem Biol. 2010 Dec 17;5(12):1183-91. doi: 10.1021/cb1002366. Epub 2010 Oct 22.

14.

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity.

Catalano A, Carocci A, Cavalluzzi MM, Di Mola A, Lentini G, Lovece A, Dipalma A, Costanza T, Desaphy JF, Conte Camerino D, Franchini C.

Arch Pharm (Weinheim). 2010 Jun;343(6):325-32. doi: 10.1002/ardp.200900218.

PMID:
20509146
15.

Synthesis and biological evaluation of 2-mercapto-1,3-benzothiazole derivatives with potential antimicrobial activity.

Franchini C, Muraglia M, Corbo F, Florio MA, Di Mola A, Rosato A, Matucci R, Nesi M, van Bambeke F, Vitali C.

Arch Pharm (Weinheim). 2009 Oct;342(10):605-13. doi: 10.1002/ardp.200900092.

PMID:
19753564
16.

AT1 receptor ligands: virtual-screening-based design with TOPP descriptors, synthesis, and biological evaluation of pyrrolidine derivatives.

Lamanna C, Catalano A, Carocci A, Di Mola A, Franchini C, Tortorella V, Vanderheyden PM, Sinicropi MS, Watson KA, Sciabola S.

ChemMedChem. 2007 Sep;2(9):1298-310.

PMID:
17628868

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