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Items: 1 to 20 of 35

1.

Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling.

Zakrzewska M, Opalinski L, Haugsten EM, Otlewski J, Wiedlocha A.

Int J Mol Sci. 2019 Apr 12;20(8). pii: E1826. doi: 10.3390/ijms20081826.

2.

Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation.

Kostas M, Lampart A, Bober J, Wiedlocha A, Tomala J, Krowarsch D, Otlewski J, Zakrzewska M.

J Mol Biol. 2018 Oct 19;430(21):4087-4101. doi: 10.1016/j.jmb.2018.08.004. Epub 2018 Aug 9.

3.

Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors.

Krzyscik MA, Zakrzewska M, Sørensen V, Sokolowska-Wedzina A, Lobocki M, Swiderska KW, Krowarsch D, Wiedlocha A, Otlewski J.

ACS Omega. 2017 Jul 31;2(7):3792-3805. doi: 10.1021/acsomega.7b00116. Epub 2017 Jul 21.

4.

Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors.

Kostas M, Haugsten EM, Zhen Y, Sørensen V, Szybowska P, Fiorito E, Lorenz S, Jones N, de Souza GA, Wiedlocha A, Wesche J.

Mol Cell Proteomics. 2018 May;17(5):850-870. doi: 10.1074/mcp.RA117.000538. Epub 2018 Jan 25.

5.

Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport.

Haugsten EM, Sørensen V, Kunova Bosakova M, de Souza GA, Krejci P, Wiedlocha A, Wesche J.

J Proteome Res. 2016 Oct 7;15(10):3841-3855. Epub 2016 Sep 26.

PMID:
27615514
6.

The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo.

Wendel T, Zhen Y, Suo Z, Bruheim S, Wiedlocha A.

Exp Cell Res. 2016 Jan 15;340(2):220-6. doi: 10.1016/j.yexcr.2015.12.017. Epub 2015 Dec 31.

PMID:
26748184
7.

Instability restricts signaling of multiple fibroblast growth factors.

Buchtova M, Chaloupkova R, Zakrzewska M, Vesela I, Cela P, Barathova J, Gudernova I, Zajickova R, Trantirek L, Martin J, Kostas M, Otlewski J, Damborsky J, Kozubik A, Wiedlocha A, Krejci P.

Cell Mol Life Sci. 2015 Jun;72(12):2445-59. doi: 10.1007/s00018-015-1856-8. Epub 2015 Feb 18.

PMID:
25854632
8.

Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1).

Sletten T, Kostas M, Bober J, Sorensen V, Yadollahi M, Olsnes S, Tomala J, Otlewski J, Zakrzewska M, Wiedlocha A.

PLoS One. 2014 Mar 4;9(3):e90687. doi: 10.1371/journal.pone.0090687. eCollection 2014.

9.

ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling.

Zakrzewska M, Haugsten EM, Nadratowska-Wesolowska B, Oppelt A, Hausott B, Jin Y, Otlewski J, Wesche J, Wiedlocha A.

Sci Signal. 2013 Feb 12;6(262):ra11. doi: 10.1126/scisignal.2003087.

PMID:
23405013
10.

FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation.

Szlachcic A, Pala K, Zakrzewska M, Jakimowicz P, Wiedlocha A, Otlewski J.

Int J Nanomedicine. 2012;7:5915-27. doi: 10.2147/IJN.S36575. Epub 2012 Nov 29.

11.

Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.

Zhen Y, Sørensen V, Skjerpen CS, Haugsten EM, Jin Y, Wälchli S, Olsnes S, Wiedlocha A.

Traffic. 2012 May;13(5):650-64. doi: 10.1111/j.1600-0854.2012.01341.x. Epub 2012 Mar 4.

12.

Simultaneously targeting mitochondria and endoplasmic reticulum by photodynamic therapy induces apoptosis in human lymphoma cells.

Shahzidi S, Cunderlíková B, Więdłocha A, Zhen Y, Vasovič V, Nesland JM, Peng Q.

Photochem Photobiol Sci. 2011 Nov;10(11):1773-82. doi: 10.1039/c1pp05169e. Epub 2011 Sep 1.

PMID:
21881674
13.

The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein.

Jin Y, Zhen Y, Haugsten EM, Wiedlocha A.

Cell Signal. 2011 Nov;23(11):1758-66. doi: 10.1016/j.cellsig.2011.06.010. Epub 2011 Jun 30.

PMID:
21745565
14.

Translocation of exogenous FGF1 into cytosol and nucleus is a periodic event independent of receptor kinase activity.

Zakrzewska M, Sørensen V, Jin Y, Wiedlocha A, Olsnes S.

Exp Cell Res. 2011 Apr 15;317(7):1005-15. doi: 10.1016/j.yexcr.2011.01.003. Epub 2011 Jan 8.

PMID:
21223966
15.

Roles of fibroblast growth factor receptors in carcinogenesis.

Haugsten EM, Wiedlocha A, Olsnes S, Wesche J.

Mol Cancer Res. 2010 Nov;8(11):1439-52. doi: 10.1158/1541-7786.MCR-10-0168. Epub 2010 Oct 13. Review.

16.

Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.

Zakrzewska M, Wiedlocha A, Szlachcic A, Krowarsch D, Otlewski J, Olsnes S.

J Biol Chem. 2009 Sep 11;284(37):25388-403. doi: 10.1074/jbc.M109.001289. Epub 2009 Jul 2.

17.

Size limitation in translocation of fibroblast growth factor 1 fusion proteins across the endosomal membrane.

Zakrzewska M, Zhen Y, Wiedlocha A, Olsnes S, Wesche J.

Biochemistry. 2009 Aug 4;48(30):7209-18. doi: 10.1021/bi9007353.

PMID:
19558187
18.

Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus.

Sørensen V, Zhen Y, Zakrzewska M, Haugsten EM, Wälchli S, Nilsen T, Olsnes S, Wiedlocha A.

Mol Cell Biol. 2008 Jun;28(12):4129-41. doi: 10.1128/MCB.02117-07. Epub 2008 Apr 14.

19.

FGF-1: from biology through engineering to potential medical applications.

Zakrzewska M, Marcinkowska E, Wiedlocha A.

Crit Rev Clin Lab Sci. 2008;45(1):91-135. doi: 10.1080/10408360701713120 . Review.

PMID:
18293181
20.

A nuclear export sequence located on a beta-strand in fibroblast growth factor-1.

Nilsen T, Rosendal KR, Sørensen V, Wesche J, Olsnes S, Wiedłocha A.

J Biol Chem. 2007 Sep 7;282(36):26245-56. Epub 2007 Jul 6.

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