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The new H2S-releasing compound ACS94 exerts protective effects through the modulation of thiol homoeostasis.

Giustarini D, Tazzari V, Bassanini I, Rossi R, Sparatore A.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1392-1404. doi: 10.1080/14756366.2018.1509211.


Benzimidazole derivatives endowed with potent antileishmanial activity.

Tonelli M, Gabriele E, Piazza F, Basilico N, Parapini S, Tasso B, Loddo R, Sparatore F, Sparatore A.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):210-226. doi: 10.1080/14756366.2017.1410480.


In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial.

Basilico N, Parapini S, Sparatore A, Romeo S, Misiano P, Vivas L, Yardley V, Croft SL, Habluetzel A, Lucantoni L, Renia L, Russell B, Suwanarusk R, Nosten F, Dondio G, Bigogno C, Jabes D, Taramelli D.

Molecules. 2017 Dec 1;22(12). pii: E2102. doi: 10.3390/molecules22122102.


New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-κB transcription factors.

Gabriele E, Brambilla D, Ricci C, Regazzoni L, Taguchi K, Ferri N, Asai A, Sparatore A.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):1012-1028. doi: 10.1080/14756366.2017.1350658.


Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain.

Gabriele E, Ricci C, Meneghetti F, Ferri N, Asai A, Sparatore A.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):337-344. doi: 10.1080/14756366.2016.1252757.


Antiviral activity of benzotriazole derivatives. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selectively inhibit Coxsackie Virus B5.

Loddo R, Novelli F, Sparatore A, Tasso B, Tonelli M, Boido V, Sparatore F, Collu G, Delogu I, Giliberti G, La Colla P.

Bioorg Med Chem. 2015 Nov 1;23(21):7024-34. doi: 10.1016/j.bmc.2015.09.035. Epub 2015 Sep 25.


Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains.

Tasso B, Novelli F, Tonelli M, Barteselli A, Basilico N, Parapini S, Taramelli D, Sparatore A, Sparatore F.

ChemMedChem. 2015 Sep;10(9):1570-83. doi: 10.1002/cmdc.201500195. Epub 2015 Jul 24.


Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β-Amyloid (Aβ) Aggregation.

Tonelli M, Catto M, Tasso B, Novelli F, Canu C, Iusco G, Pisani L, Stradis AD, Denora N, Sparatore A, Boido V, Carotti A, Sparatore F.

ChemMedChem. 2015 Jun;10(6):1040-53. doi: 10.1002/cmdc.201500104. Epub 2015 Apr 29.


Clofazimine analogs with antileishmanial and antiplasmodial activity.

Barteselli A, Casagrande M, Basilico N, Parapini S, Rusconi CM, Tonelli M, Boido V, Taramelli D, Sparatore F, Sparatore A.

Bioorg Med Chem. 2015 Jan 1;23(1):55-65. doi: 10.1016/j.bmc.2014.11.028. Epub 2014 Nov 26.


Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines.

Tonelli M, Novelli F, Tasso B, Sparatore A, Boido V, Sparatore F, Cannas S, Molicotti P, Zanetti S, Parapini S, Loddo R.

Bioorg Med Chem. 2014 Dec 15;22(24):6837-45. doi: 10.1016/j.bmc.2014.10.035. Epub 2014 Oct 31.


Synthesis and evaluation of the antiplasmodial activity of novel indeno[2,1-c]quinoline derivatives.

Barteselli A, Parapini S, Basilico N, Mommo D, Sparatore A.

Bioorg Med Chem. 2014 Nov 1;22(21):5757-65. doi: 10.1016/j.bmc.2014.09.040. Epub 2014 Oct 10.


Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.

Tonelli M, Novelli F, Tasso B, Vazzana I, Sparatore A, Boido V, Sparatore F, La Colla P, Sanna G, Giliberti G, Busonera B, Farci P, Ibba C, Loddo R.

Bioorg Med Chem. 2014 Sep 1;22(17):4893-909. doi: 10.1016/j.bmc.2014.06.043. Epub 2014 Jul 1.


Hydrogen sulfide inhibits human platelet aggregation in vitro in part by interfering gap junction channels: effects of ACS14, a hydrogen sulfide-releasing aspirin.

Gao L, Cheng C, Sparatore A, Zhang H, Wang C.

Heart Lung Circ. 2015 Jan;24(1):77-85. doi: 10.1016/j.hlc.2014.05.019. Epub 2014 Jun 24.


Hydrogen sulfide releasing aspirin, ACS14, attenuates high glucose-induced increased methylglyoxal and oxidative stress in cultured vascular smooth muscle cells.

Huang Q, Sparatore A, Del Soldato P, Wu L, Desai K.

PLoS One. 2014 Jun 4;9(6):e97315. doi: 10.1371/journal.pone.0097315. eCollection 2014.


Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent.

Giustarini D, Fanti P, Sparatore A, Matteucci E, Rossi R.

Biochem Pharmacol. 2014 May 15;89(2):246-54. doi: 10.1016/j.bcp.2014.03.005. Epub 2014 Mar 14.


Therapeutic effect of hydrogen sulfide-releasing L-Dopa derivative ACS84 on 6-OHDA-induced Parkinson's disease rat model.

Xie L, Hu LF, Teo XQ, Tiong CX, Tazzari V, Sparatore A, Del Soldato P, Dawe GS, Bian JS.

PLoS One. 2013;8(4):e60200. doi: 10.1371/journal.pone.0060200. Epub 2013 Apr 3.


Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice.

Zhang H, Guo C, Zhang A, Fan Y, Gu T, Wu D, Sparatore A, Wang C.

Eur J Pharmacol. 2012 Dec 15;697(1-3):106-16. doi: 10.1016/j.ejphar.2012.10.005. Epub 2012 Oct 16.


H(2)S-releasing aspirin protects against aspirin-induced gastric injury via reducing oxidative stress.

Liu L, Cui J, Song CJ, Bian JS, Sparatore A, Soldato PD, Wang XY, Yan CD.

PLoS One. 2012;7(9):e46301. doi: 10.1371/journal.pone.0046301. Epub 2012 Sep 28.


Hydrogen sulfide-releasing aspirin derivative ACS14 exerts strong antithrombotic effects in vitro and in vivo.

Pircher J, Fochler F, Czermak T, Mannell H, Kraemer BF, Wörnle M, Sparatore A, Del Soldato P, Pohl U, Krötz F.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2884-91. doi: 10.1161/ATVBAHA.112.300627. Epub 2012 Sep 27.


Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline.

Casagrande M, Barteselli A, Basilico N, Parapini S, Taramelli D, Sparatore A.

Bioorg Med Chem. 2012 Oct 1;20(19):5965-79. doi: 10.1016/j.bmc.2012.07.040. Epub 2012 Aug 2.


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