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Items: 1 to 20 of 54

1.

Meeting report: Fourth Summer School on Innovative Approaches for Identification of Antiviral Agents (IAAASS).

Le Grice S, Maccioni E, Corona A, Parolin C, Tramontano E.

Antiviral Res. 2019 Feb;162:110-117. doi: 10.1016/j.antiviral.2018.12.013. Epub 2018 Dec 23. Review.

PMID:
30586561
2.

Insights into Ebola Virus VP35 and VP24 Interferon inhibitory functions and their initial exploitation as drug targets

Fanunza E, Frau A, Corona A, Tramontano E.

Infect Disord Drug Targets. 2018 Nov 23. doi: 10.2174/1871526519666181123145540. [Epub ahead of print]

PMID:
30468131
3.

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors.

Massari S, Corona A, Distinto S, Desantis J, Caredda A, Sabatini S, Manfroni G, Felicetti T, Cecchetti V, Pannecouque C, Maccioni E, Tramontano E, Tabarrini O.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):55-74. doi: 10.1080/14756366.2018.1523901.

4.

Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques.

Costa G, Rocca R, Corona A, Grandi N, Moraca F, Romeo I, Talarico C, Gagliardi MG, Ambrosio FA, Ortuso F, Alcaro S, Distinto S, Maccioni E, Tramontano E, Artese A.

Eur J Med Chem. 2019 Jan 1;161:1-10. doi: 10.1016/j.ejmech.2018.10.029. Epub 2018 Oct 13.

PMID:
30342421
5.

Identification of Myricetin as an Ebola Virus VP35-Double-Stranded RNA Interaction Inhibitor through a Novel Fluorescence-Based Assay.

Daino GL, Frau A, Sanna C, Rigano D, Distinto S, Madau V, Esposito F, Fanunza E, Bianco G, Taglialatela-Scafati O, Zinzula L, Maccioni E, Corona A, Tramontano E.

Biochemistry. 2018 Nov 6;57(44):6367-6378. doi: 10.1021/acs.biochem.8b00892. Epub 2018 Oct 22.

PMID:
30298725
6.

Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies.

Poongavanam V, Corona A, Steinmann C, Scipione L, Grandi N, Pandolfi F, Di Santo R, Costi R, Esposito F, Tramontano E, Kongsted J.

Medchemcomm. 2018 Feb 1;9(3):562-575. doi: 10.1039/c7md00600d. eCollection 2018 Mar 1.

7.

Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication.

Sanna C, Scognamiglio M, Fiorentino A, Corona A, Graziani V, Caredda A, Cortis P, Montisci M, Ceresola ER, Canducci F, Poli F, Tramontano E, Esposito F.

PLoS One. 2018 Mar 30;13(3):e0195168. doi: 10.1371/journal.pone.0195168. eCollection 2018.

8.

Development and Validation of a Novel Dual Luciferase Reporter Gene Assay to Quantify Ebola Virus VP24 Inhibition of IFN Signaling.

Fanunza E, Frau A, Sgarbanti M, Orsatti R, Corona A, Tramontano E.

Viruses. 2018 Feb 24;10(2). pii: E98. doi: 10.3390/v10020098.

9.

Insights into the homo-oligomerization properties of N-terminal coiled-coil domain of Ebola virus VP35 protein.

Ramaswamy VK, Di Palma F, Vargiu AV, Corona A, Piano D, Ruggerone P, Zinzula L, Tramontano E.

Virus Res. 2018 Mar 2;247:61-70. doi: 10.1016/j.virusres.2018.02.003. Epub 2018 Feb 7.

PMID:
29427597
10.

Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy).

Sanna C, Rigano D, Corona A, Piano D, Formisano C, Farci D, Franzini G, Ballero M, Chianese G, Tramontano E, Taglialatela-Scafati O, Esposito F.

Nat Prod Res. 2018 Feb 4:1-6. doi: 10.1080/14786419.2018.1434649. [Epub ahead of print]

PMID:
29397771
11.

Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions.

Corona A, Onnis V, Deplano A, Bianco G, Demurtas M, Distinto S, Cheng YC, Alcaro S, Esposito F, Tramontano E.

Pathog Dis. 2017 Aug 31;75(6). doi: 10.1093/femspd/ftx078.

12.

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms.

Bianco G, Meleddu R, Distinto S, Cottiglia F, Gaspari M, Melis C, Corona A, Angius R, Angeli A, Taverna D, Alcaro S, Leitans J, Kazaks A, Tars K, Supuran CT, Maccioni E.

ACS Med Chem Lett. 2017 Jun 21;8(8):792-796. doi: 10.1021/acsmedchemlett.7b00205. eCollection 2017 Aug 10.

13.

Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action.

Esposito F, Mandrone M, Del Vecchio C, Carli I, Distinto S, Corona A, Lianza M, Piano D, Tacchini M, Maccioni E, Cottiglia F, Saccon E, Poli F, Parolin C, Tramontano E.

Pathog Dis. 2017 Aug 31;75(6). doi: 10.1093/femspd/ftx065.

PMID:
28637198
14.

Uvaria angolensis as a promising source of inhibitors of HIV-1 RT-associated RNA-dependent DNA polymerase and RNase H functions.

Ngoutane Mfopa A, Corona A, Eloh K, Tramontano E, Frau A, Boyom FF, Caboni P, Tocco G.

Nat Prod Res. 2018 Mar;32(6):640-647. doi: 10.1080/14786419.2017.1332615. Epub 2017 May 25.

PMID:
28540745
15.

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N'-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain.

Carcelli M, Rogolino D, Gatti A, Pala N, Corona A, Caredda A, Tramontano E, Pannecouque C, Naesens L, Esposito F.

Front Microbiol. 2017 Mar 20;8:440. doi: 10.3389/fmicb.2017.00440. eCollection 2017.

16.

Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase.

Sonar VP, Corona A, Distinto S, Maccioni E, Meleddu R, Fois B, Floris C, Malpure NV, Alcaro S, Tramontano E, Cottiglia F.

Eur J Med Chem. 2017 Apr 21;130:248-260. doi: 10.1016/j.ejmech.2017.02.054. Epub 2017 Feb 24.

PMID:
28254698
17.

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B.

Meleddu R, Distinto S, Cirilli R, Alcaro S, Yanez M, Sanna ML, Corona A, Melis C, Bianco G, Matyus P, Cottiglia F, Maccioni E.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):264-270. doi: 10.1080/14756366.2016.1247061.

18.

Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding.

Martini R, Esposito F, Corona A, Ferrarese R, Ceresola ER, Visconti L, Tintori C, Barbieri A, Calcaterra A, Iovine V, Canducci F, Tramontano E, Botta M.

Chembiochem. 2017 Feb 16;18(4):374-377. doi: 10.1002/cbic.201600592. Epub 2017 Jan 18.

PMID:
27992102
19.

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase.

Meleddu R, Distinto S, Corona A, Tramontano E, Bianco G, Melis C, Cottiglia F, Maccioni E.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):130-136. doi: 10.1080/14756366.2016.1238366. Epub 2016 Oct 21.

20.

Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication.

Esposito F, Carli I, Del Vecchio C, Xu L, Corona A, Grandi N, Piano D, Maccioni E, Distinto S, Parolin C, Tramontano E.

Phytomedicine. 2016 Nov 15;23(12):1383-1391. doi: 10.1016/j.phymed.2016.08.001. Epub 2016 Aug 10.

PMID:
27765358

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