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Items: 1 to 20 of 56

1.

Exploring isoxazoles and pyrrolidinones decorated with the 4,6-dimethoxy-1,3,5-triazine unit as human farnesyltransferase inhibitors.

Lucescu L, Ghinet A, Shova S, Magnez R, Thuru X, Farce A, Rigo B, Belei D, Dubois J, Bîcu E.

Arch Pharm (Weinheim). 2019 May;352(5):e1800227. doi: 10.1002/ardp.201800227. Epub 2019 Apr 4.

PMID:
30947375
2.

New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.

Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Evrard C, Le Fur N, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, Dallemagne P, Buée-Scherrer V, Blum D, Hamdane M, Buée L, Melnyk P.

Neurobiol Dis. 2019 Mar 27. pii: S0969-9961(18)30327-9. doi: 10.1016/j.nbd.2019.03.028. [Epub ahead of print]

PMID:
30928644
3.

In vitro and in silico hormonal activity studies of di-(2-ethylhexyl)terephthalate, a di-(2-ethylhexyl)phthalate substitute used in medical devices, and its metabolites.

Kambia NK, Séverin I, Farce A, Moreau E, Dahbi L, Duval C, Dine T, Sautou V, Chagnon MC.

J Appl Toxicol. 2019 Mar 8. doi: 10.1002/jat.3792. [Epub ahead of print]

PMID:
30847963
4.

Access to 3-spiroindolizines containing an isoindole ring through intra-molecular arylation of spiro-N-acyliminium species: a new family of potent farnesyltransferase inhibitors.

Pesquet A, Marzag H, Knorr M, Strohmann C, Lawson AM, Ghinet A, Dubois J, Amaury F, Daïch A, Othman M.

Org Biomol Chem. 2019 Mar 6;17(10):2798-2808. doi: 10.1039/c8ob02612b.

PMID:
30793727
5.

Chlorinated and brominated bisphenol A derivatives: Synthesis, characterization and determination in water samples.

Doumas M, Rouillon S, Venisse N, Nadeau C, Pierre Eugene P, Farce A, Chavatte P, Dupuis A, Migeot V, Carato P.

Chemosphere. 2018 Dec;213:434-442. doi: 10.1016/j.chemosphere.2018.09.061. Epub 2018 Sep 12.

PMID:
30243209
6.

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.

Gibault F, Coevoet M, Sturbaut M, Farce A, Renault N, Allemand F, Guichou JF, Drucbert AS, Foulon C, Magnez R, Thuru X, Corvaisier M, Huet G, Chavatte P, Melnyk P, Bailly F, Cotelle P.

Cancers (Basel). 2018 May 8;10(5). pii: E140. doi: 10.3390/cancers10050140.

7.

Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands.

Sansook S, Tuo W, Bollier M, Barczyk A, Dezitter X, Klupsch F, Leleu-Chavain N, Farce A, Tizzard GJ, Coles SJ, Spencer J, Millet R.

Future Med Chem. 2018 Mar 1;10(6):631-638. doi: 10.4155/fmc-2017-0200. Epub 2018 Feb 8.

PMID:
29419319
8.

On the discovery of new potent human farnesyltransferase inhibitors: emerging pyroglutamic derivatives.

Homerin G, Lipka E, Rigo B, Farce A, Dubois J, Ghinet A.

Org Biomol Chem. 2017 Oct 4;15(38):8110-8118. doi: 10.1039/c7ob01489a.

PMID:
28905970
9.

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.

Pirat C, Dacquet C, Leclerc V, Hennuyer N, Beucher-Gaudin M, Zanirato G, Géant A, Staels B, Ktorza A, Farce A, Caignard DH, Berthelot P, Lebegue N.

Eur J Med Chem. 2017 Sep 8;137:310-326. doi: 10.1016/j.ejmech.2017.06.006. Epub 2017 Jun 12.

PMID:
28609708
10.

Methylene versus carbonyl bridge in the structure of new tubulin polymerization inhibitors with tricyclic A-rings.

Moise IM, Bîcu E, Dubois J, Farce A, Rigo B, Ghinet A.

Bioorg Med Chem. 2016 Nov 15;24(22):6021-6030. doi: 10.1016/j.bmc.2016.09.063. Epub 2016 Sep 26.

PMID:
27707624
11.

New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation.

Moise IM, Ghinet A, Belei D, Dubois J, Farce A, Bîcu E.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3730-4. doi: 10.1016/j.bmcl.2016.05.074. Epub 2016 May 26.

PMID:
27282741
12.

Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents.

Ghinet A, Moise IM, Rigo B, Homerin G, Farce A, Dubois J, Bîcu E.

Bioorg Med Chem. 2016 May 15;24(10):2307-17. doi: 10.1016/j.bmc.2016.04.001. Epub 2016 Apr 1.

PMID:
27073050
13.

Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4: A comparison between the linkage positions of the 3,4,5-trimethoxystyrene unit.

Do CV, Faouzi A, Barette C, Farce A, Fauvarque MO, Colomb E, Catry L, Berthier-Vergnes O, Haftek M, Barret R, Lomberget T.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):174-80. doi: 10.1016/j.bmcl.2015.11.010. Epub 2015 Nov 10.

PMID:
26602281
14.

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.

Dumitriu GM, Bîcu E, Belei D, Rigo B, Dubois J, Farce A, Ghinet A.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4447-52. doi: 10.1016/j.bmcl.2015.09.008. Epub 2015 Sep 7.

PMID:
26372651
15.

Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate.

Kambia N, Farce A, Belarbi K, Gressier B, Luyckx M, Chavatte P, Dine T.

J Enzyme Inhib Med Chem. 2016;31(3):448-55. doi: 10.3109/14756366.2015.1037748. Epub 2015 May 5.

PMID:
25942360
16.

Studies on indolizines. Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds.

Ghinet A, Abuhaie CM, Gautret P, Rigo B, Dubois J, Farce A, Belei D, Bîcu E.

Eur J Med Chem. 2015 Jan 7;89:115-27. doi: 10.1016/j.ejmech.2014.10.041. Epub 2014 Oct 16.

PMID:
25462232
17.

Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase.

Dumea C, Belei D, Ghinet A, Dubois J, Farce A, Bîcu E.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5777-5781. doi: 10.1016/j.bmcl.2014.10.044. Epub 2014 Oct 22.

PMID:
25453818
18.

Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of CD1d-glycolipids dynamics simulations.

Laurent X, Renault N, Farce A, Chavatte P, Hénon E.

PLoS Comput Biol. 2014 Nov 6;10(11):e1003902. doi: 10.1371/journal.pcbi.1003902. eCollection 2014 Nov.

19.

Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase.

Dumitriu GM, Ghinet A, Bîcu E, Rigo B, Dubois J, Farce A, Belei D.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3180-5. doi: 10.1016/j.bmcl.2014.04.102. Epub 2014 May 12.

PMID:
24856060
20.

Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.

Laurent X, Bertin B, Renault N, Farce A, Speca S, Milhomme O, Millet R, Desreumaux P, Hénon E, Chavatte P.

J Med Chem. 2014 Jul 10;57(13):5489-508. doi: 10.1021/jm4010863. Epub 2014 Feb 12. Review.

PMID:
24428717

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