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Items: 18

1.

Validated LC-MS/MS assay for quantification of the newly approved tyrosine kinase inhibitor, dacomitinib, and application to investigating its metabolic stability.

Abdelhameed AS, Kadi AA, Attwa MW, AlRabiah H.

PLoS One. 2019 Apr 4;14(4):e0214598. doi: 10.1371/journal.pone.0214598. eCollection 2019.

2.

Novel BTK inhibitor acalabrutinib (ACP-196) tightly binds to site I of the human serum albumin as observed by spectroscopic and computational studies.

Abdelhameed AS, Alanazi AM, Bakheit AH, Hassan ES, Herqash RN, Almutairi FM.

Int J Biol Macromol. 2019 Apr 15;127:536-543. doi: 10.1016/j.ijbiomac.2019.01.083. Epub 2019 Jan 18.

PMID:
30664965
3.

Reactive intermediates and bioactivation pathways characterization of avitinib by LC-MS/MS: In vitro metabolic investigation.

Attwa MW, Kadi AA, Abdelhameed AS.

J Pharm Biomed Anal. 2019 Feb 5;164:659-667. doi: 10.1016/j.jpba.2018.11.033. Epub 2018 Nov 17.

PMID:
30472584
5.

Biophysical and In Silico Studies of the Interaction between the Anti-Viral Agents Acyclovir and Penciclovir, and Human Serum Albumin.

Abdelhameed AS, Bakheit AH, Almutairi FM, AlRabiah H, Kadi AA.

Molecules. 2017 Nov 5;22(11). pii: E1906. doi: 10.3390/molecules22111906.

6.

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling.

Abdel-Aziz HA, Eldehna WM, Keeton AB, Piazza GA, Kadi AA, Attwa MW, Abdelhameed AS, Attia MI.

Drug Des Devel Ther. 2017 Aug 9;11:2333-2346. doi: 10.2147/DDDT.S140164. eCollection 2017.

7.

Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity.

Alam P, Beg AZ, Siddiqi MK, Chaturvedi SK, Rajpoot RK, Ajmal MR, Zaman M, Abdelhameed AS, Khan RH.

Arch Biochem Biophys. 2017 May 1;621:54-62. doi: 10.1016/j.abb.2017.04.005. Epub 2017 Apr 12.

PMID:
28412155
8.

Fluorescence spectroscopic and molecular docking studies of the binding interaction between the new anaplastic lymphoma kinase inhibitor crizotinib and bovine serum albumin.

Abdelhameed AS, Alanazi AM, Bakheit AH, Darwish HW, Ghabbour HA, Darwish IA.

Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jan 15;171:174-182. doi: 10.1016/j.saa.2016.08.005. Epub 2016 Aug 5.

PMID:
27526341
9.

An LC-MS/MS method for rapid and sensitive high-throughput simultaneous determination of various protein kinase inhibitors in human plasma.

Abdelhameed AS, Attwa MW, Kadi AA.

Biomed Chromatogr. 2017 Feb;31(2). doi: 10.1002/bmc.3793. Epub 2016 Aug 12.

PMID:
27450926
10.
11.

Interplay of multiple interaction forces: Binding of tyrosine kinase inhibitor nintedanib with human serum albumin.

Alam P, Abdelhameed AS, Rajpoot RK, Khan RH.

J Photochem Photobiol B. 2016 Apr;157:70-6. doi: 10.1016/j.jphotobiol.2016.02.009. Epub 2016 Feb 5.

PMID:
26894847
12.

A highly efficient and sensitive LC-MS/MS method for the determination of afatinib in human plasma: application to a metabolic stability study.

Kadi AA, Abdelhameed AS, Darwish HW, Attwa MW, Al-Shakliah NS.

Biomed Chromatogr. 2016 Aug;30(8):1248-55. doi: 10.1002/bmc.3674. Epub 2016 Jan 24.

PMID:
26683307
13.

Binding of Janus kinase inhibitor tofacitinib with human serum albumin: multi-technique approach.

Abdelhameed AS, Alam P, Khan RH.

J Biomol Struct Dyn. 2016 Sep;34(9):2037-44. doi: 10.1080/07391102.2015.1104522. Epub 2016 May 9.

PMID:
26440737
14.

A Stability-Indicating HPLC-DAD Method for Determination of Stiripentol: Development, Validation, Kinetics, Structure Elucidation and Application to Commercial Dosage Form.

Darwish HW, Abdelhameed AS, Attia MI, Bakheit AH, Khalil NY, Al-Majed AA.

J Anal Methods Chem. 2014;2014:638951. doi: 10.1155/2014/638951. Epub 2014 Oct 14.

15.

HPLC method with monolithic column for simultaneous determination of irbesartan and hydrochlorothiazide in tablets.

Alanazi AM, Abdelhameed AS, Khalil NY, Khan AA, Darwish IA.

Acta Pharm. 2014 Jun;64(2):187-98. doi: 10.2478/acph-2014-0014.

PMID:
24914719
16.

Multistage fragmentation of ion trap mass spectrometry system and pseudo-MS3 of triple quadrupole mass spectrometry characterize certain (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones: a comparative study.

Abdelhameed AS, Kadi AA, Abdel-Aziz HA, Angawi RF, Attwa MW, Al-Rashood KA.

ScientificWorldJournal. 2014 Feb 19;2014:702819. doi: 10.1155/2014/702819. eCollection 2014.

17.

Induced in-source fragmentation pattern of certain novel (1Z,2E)-N-(aryl)propanehydrazonoyl chlorides by electrospray mass spectrometry (ESI-MS/MS).

Abdelhameed AS, Attwa MW, Abdel-Aziz HA, Kadi AA.

Chem Cent J. 2013 Jan 25;7(1):16. doi: 10.1186/1752-153X-7-16.

18.

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