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Items: 1 to 20 of 49

1.

Anionic Polymerization Using Flow Microreactors.

Takahashi Y, Nagaki A.

Molecules. 2019 Apr 18;24(8). pii: E1532. doi: 10.3390/molecules24081532. Review.

2.

Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing.

Nagaki A, Sasatsuki K, Ishiuchi S, Miuchi N, Takumi M, Yoshida JI.

Chemistry. 2019 Apr 1;25(19):4946-4950. doi: 10.1002/chem.201900743. Epub 2019 Mar 14.

PMID:
30775815
3.

Alkyllithium Compounds Bearing Electrophilic Functional Groups: A Flash Chemistry Approach.

Nagaki A, Yamashita H, Hirose K, Tsuchihashi Y, Yoshida JI.

Angew Chem Int Ed Engl. 2019 Mar 18;58(12):4027-4030. doi: 10.1002/anie.201814088. Epub 2019 Feb 14.

PMID:
30690827
4.

Generation of hazardous methyl azide and its application to synthesis of a key-intermediate of picarbutrazox, a new potent pesticide in flow.

Ichinari D, Nagaki A, Yoshida JI.

Bioorg Med Chem. 2017 Dec 1;25(23):6224-6228. doi: 10.1016/j.bmc.2017.07.005. Epub 2017 Jul 8.

PMID:
28720330
5.

Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized α-Ketoamides.

Nagaki A, Takahashi Y, Yoshida J.

Angew Chem Int Ed Engl. 2016 Apr 18;55(17):5327-31. doi: 10.1002/anie.201601386. Epub 2016 Mar 15.

PMID:
26990703
6.

Benzyllithiums bearing aldehyde carbonyl groups. A flash chemistry approach.

Nagaki A, Tsuchihashi Y, Haraki S, Yoshida J.

Org Biomol Chem. 2015 Jul 14;13(26):7140-5. doi: 10.1039/c5ob00958h. Epub 2015 Jun 9.

PMID:
26055984
7.

Reactions of difunctional electrophiles with functionalized aryllithium compounds: remarkable chemoselectivity by flash chemistry.

Nagaki A, Imai K, Ishiuchi S, Yoshida J.

Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1914-8. doi: 10.1002/anie.201410717. Epub 2014 Dec 12.

PMID:
25504778
8.

Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides.

Nagaki A, Tokuoka S, Yoshida J.

Chem Commun (Camb). 2014 Dec 11;50(95):15079-81. doi: 10.1039/c4cc06709f.

PMID:
25331911
9.

Three-component coupling based on flash chemistry. Carbolithiation of benzyne with functionalized aryllithiums followed by reactions with electrophiles.

Nagaki A, Ichinari D, Yoshida J.

J Am Chem Soc. 2014 Sep 3;136(35):12245-8. doi: 10.1021/ja5071762. Epub 2014 Aug 25.

PMID:
25153763
10.

Extremely fast gas/liquid reactions in flow microreactors: carboxylation of short-lived organolithiums.

Nagaki A, Takahashi Y, Yoshida J.

Chemistry. 2014 Jun 23;20(26):7931-4. doi: 10.1002/chem.201402520. Epub 2014 May 23.

PMID:
24863501
11.

Flow microreactor synthesis in organo-fluorine chemistry.

Amii H, Nagaki A, Yoshida J.

Beilstein J Org Chem. 2013 Dec 5;9:2793-802. doi: 10.3762/bjoc.9.314. Review.

12.

Continuous flow synthesis.

Yoshida J, Nagaki A, Yamada D.

Drug Discov Today Technol. 2013 Spring;10(1):e53-9. doi: 10.1016/j.ddtec.2012.10.013. Review.

PMID:
24050230
13.

Flash chemistry: flow chemistry that cannot be done in batch.

Yoshida J, Takahashi Y, Nagaki A.

Chem Commun (Camb). 2013 Nov 4;49(85):9896-904. doi: 10.1039/c3cc44709j.

PMID:
24042967
14.

Reactions of organolithiums with dialkyl oxalates. A flow microreactor approach to synthesis of functionalized α-keto esters.

Nagaki A, Ichinari D, Yoshida J.

Chem Commun (Camb). 2013 Apr 21;49(31):3242-4. doi: 10.1039/c3cc40392k. Epub 2013 Mar 13.

PMID:
23486774
15.

Synthesis of functionalized aryl fluorides using organolithium reagents in flow microreactors.

Nagaki A, Uesugi Y, Kim H, Yoshida J.

Chem Asian J. 2013 Apr;8(4):705-8. doi: 10.1002/asia.201201191. Epub 2013 Feb 7. No abstract available.

PMID:
23401379
16.

Synthesis of 1,2,3,4-tetrahydroisoquinolines by microreactor-mediated thermal isomerization of laterally lithiated arylaziridines.

Giovine A, Musio B, Degennaro L, Falcicchio A, Nagaki A, Yoshida J, Luisi R.

Chemistry. 2013 Feb 4;19(6):1872-6. doi: 10.1002/chem.201203533. Epub 2013 Jan 15.

PMID:
23322634
17.

Flow synthesis of arylboronic esters bearing electrophilic functional groups and space integration with Suzuki-Miyaura coupling without intentionally added base.

Nagaki A, Moriwaki Y, Yoshida J.

Chem Commun (Camb). 2012 Nov 25;48(91):11211-3. doi: 10.1039/c2cc36197c. Epub 2012 Oct 11.

PMID:
23059706
18.

Flash generation of a highly reactive Pd catalyst for Suzuki-Miyaura coupling by using a flow microreactor.

Nagaki A, Takabayashi N, Moriwaki Y, Yoshida J.

Chemistry. 2012 Sep 17;18(38):11871-5. doi: 10.1002/chem.201201579. Epub 2012 Aug 17.

PMID:
22903340
19.

Cross-coupling of aryllithiums with aryl and vinyl halides in flow microreactors.

Nagaki A, Moriwaki Y, Haraki S, Kenmoku A, Takabayashi N, Hayashi A, Yoshida J.

Chem Asian J. 2012 May;7(5):1061-8. doi: 10.1002/asia.201101019. Epub 2012 Feb 29.

PMID:
22378563
20.

Lithiation of 1,2-dichloroethene in flow microreactors: versatile synthesis of alkenes and alkynes by precise residence-time control.

Nagaki A, Matsuo C, Kim S, Saito K, Miyazaki A, Yoshida J.

Angew Chem Int Ed Engl. 2012 Mar 26;51(13):3245-8. doi: 10.1002/anie.201108932. Epub 2012 Feb 15. No abstract available.

PMID:
22337289

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