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Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors.

Agaram NP, Zhang L, Sung YS, Chen CL, Chung CT, Antonescu CR, Fletcher CD.

Am J Surg Pathol. 2016 Oct;40(10):1407-16. doi: 10.1097/PAS.0000000000000675.


Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern.

Haller F, Knopf J, Ackermann A, Bieg M, Kleinheinz K, Schlesner M, Moskalev EA, Will R, Satir AA, Abdelmagid IE, Giedl J, Carbon R, Rompel O, Hartmann A, Wiemann S, Metzler M, Agaimy A.

J Pathol. 2016 Apr;238(5):700-10. doi: 10.1002/path.4701.


NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer.

Park DY, Choi C, Shin E, Lee JH, Kwon CH, Jo HJ, Kim HR, Kim HS, Oh N, Lee JS, Park OK, Park E, Park J, Shin JY, Kim JI, Seo JS, Park HD, Park J.

Oncotarget. 2016 Feb 16;7(7):8399-412. doi: 10.18632/oncotarget.6724.


Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.

Russo M, Misale S, Wei G, Siravegna G, Crisafulli G, Lazzari L, Corti G, Rospo G, Novara L, Mussolin B, Bartolini A, Cam N, Patel R, Yan S, Shoemaker R, Wild R, Di Nicolantonio F, Bianchi AS, Li G, Siena S, Bardelli A.

Cancer Discov. 2016 Jan;6(1):36-44. doi: 10.1158/2159-8290.CD-15-0940. Epub 2015 Nov 6.


TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines.

Pasini L, Re A, Tebaldi T, Ricci G, Boi S, Adami V, Barbareschi M, Quattrone A.

BMC Cancer. 2015 Oct 24;15:777. doi: 10.1186/s12885-015-1791-y.


NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line.

Lee SJ, Li GG, Kim ST, Hong ME, Jang J, Yoon N, Ahn SM, Murphy D, Christiansen J, Wei G, Hornby Z, Lee DW, Park JO, Park YS, Lim HY, Hong SN, Kim SH, Kang WK, Park K, Park WY, Kim KM, Lee J.

Oncotarget. 2015 Nov 17;6(36):39028-35. doi: 10.18632/oncotarget.5494.


Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma.

Créancier L, Vandenberghe I, Gomes B, Dejean C, Blanchet JC, Meilleroux J, Guimbaud R, Selves J, Kruczynski A.

Cancer Lett. 2015 Aug 28;365(1):107-11. doi: 10.1016/j.canlet.2015.05.013. Epub 2015 May 19.


Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells.

Pajtler KW, Mahlow E, Odersky A, Lindner S, Stephan H, Bendix I, Eggert A, Schramm A, Schulte JH.

Oncotarget. 2014 Nov 30;5(22):11180-92.


Functional characterization of NTRK1 mutations identified in melanoma.

Miranda C, Mazzoni M, Sensi M, Pierotti MA, Greco A.

Genes Chromosomes Cancer. 2014 Oct;53(10):875-80. doi: 10.1002/gcc.22200. Epub 2014 Jun 26.


Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.

Vaishnavi A, Capelletti M, Le AT, Kako S, Butaney M, Ercan D, Mahale S, Davies KD, Aisner DL, Pilling AB, Berge EM, Kim J, Sasaki H, Park S, Kryukov G, Garraway LA, Hammerman PS, Haas J, Andrews SW, Lipson D, Stephens PJ, Miller VA, Varella-Garcia M, Jänne PA, Doebele RC.

Nat Med. 2013 Nov;19(11):1469-1472. doi: 10.1038/nm.3352. Epub 2013 Oct 27.


TrkAIII promotes microtubule nucleation and assembly at the centrosome in SH-SY5Y neuroblastoma cells, contributing to an undifferentiated anaplastic phenotype.

Farina AR, Di Ianni N, Cappabianca L, Ruggeri P, Ragone M, Ianni G, Gulino A, Mackay AR.

Biomed Res Int. 2013;2013:740187. doi: 10.1155/2013/740187. Epub 2013 Jun 6.


Proliferation enhanced by NGF-NTRK1 signaling makes pancreatic cancer cells more sensitive to 2DG-induced apoptosis.

Cheng Y, Diao DM, Zhang H, Song YC, Dang CX.

Int J Med Sci. 2013;10(5):634-40. doi: 10.7150/ijms.5547. Epub 2013 Mar 23.


Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells.

Pajtler KW, Rebmann V, Lindemann M, Schulte JH, Schulte S, Stauder M, Leuschner I, Schmid KW, Köhl U, Schramm A, Eggert A.

Int J Cancer. 2013 Aug 15;133(4):908-19. doi: 10.1002/ijc.28096. Epub 2013 Mar 16.


Receptor tyrosine kinase signaling mechanisms: Devolving TrkA responses with phosphoproteomics.

Bradshaw RA, Chalkley RJ, Biarc J, Burlingame AL.

Adv Biol Regul. 2013 Jan;53(1):87-96. doi: 10.1016/j.jbior.2012.10.006. Epub 2012 Nov 3. Review.


Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis.

Li M, Liang JY, Sun ZH, Zhang H, Yao ZR.

Genet Mol Res. 2012 Aug 13;11(3):2156-62. doi: 10.4238/2012.May.18.8.


Kinomic profiling approach identifies Trk as a novel radiation modulator.

Jarboe JS, Jaboin JJ, Anderson JC, Nowsheen S, Stanley JA, Naji F, Ruijtenbeek R, Tu T, Hallahan DE, Yang ES, Bonner JA, Willey CD.

Radiother Oncol. 2012 Jun;103(3):380-7. doi: 10.1016/j.radonc.2012.03.014. Epub 2012 May 5.


Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults.

Braskie MN, Jahanshad N, Stein JL, Barysheva M, Johnson K, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM.

J Neurosci. 2012 Apr 25;32(17):5964-72. doi: 10.1523/JNEUROSCI.5561-11.2012.


[Responses of pancreatic cancer cells to stimulations by nerve growth factor and the role of Trk-A expression].

Diao DM, Song YC, Hou N, Xu HF, Wang JG, Dang CX.

Nan Fang Yi Ke Da Xue Xue Bao. 2012 Mar;32(3):296-300. Chinese.


The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages.

Ley S, Weigert A, Weichand B, Henke N, Mille-Baker B, Janssen RA, Brüne B.

Oncogene. 2013 Jan 31;32(5):631-40. doi: 10.1038/onc.2012.77. Epub 2012 Mar 12.


Clinical significance of NTRK family gene expression in neuroblastomas.

Light JE, Koyama H, Minturn JE, Ho R, Simpson AM, Iyer R, Mangino JL, Kolla V, London WB, Brodeur GM.

Pediatr Blood Cancer. 2012 Aug;59(2):226-32. doi: 10.1002/pbc.23343. Epub 2011 Oct 11.

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