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Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity and reduced recurrence-free survival.

Cosgrove CM, Cohn DE, Hampel H, Frankel WL, Jones D, McElroy JP, Suarez AA, Zhao W, Chen W, Salani R, Copeland LJ, O'Malley DM, Fowler JM, Yilmaz A, Chassen AS, Pearlman R, Goodfellow PJ, Backes FJ.

Gynecol Oncol. 2017 Sep;146(3):588-595. doi: 10.1016/j.ygyno.2017.07.003. Epub 2017 Jul 11.


Effect of histone modifications on hMLH1 alternative splicing in gastric cancer.

Zhao JX, Li XW, Shi BY, Wang F, Xu ZR, Meng HL, Su YY, Wang JM, Xiao N, He Q, Wang YP, Fan YM.

Tumour Biol. 2017 Apr;39(4):1010428317697546. doi: 10.1177/1010428317697546.


The silent mutation MLH1 c.543C>T resulting in aberrant splicing can cause Lynch syndrome: a case report.

Yamaguchi T, Wakatsuki T, Kikuchi M, Horiguchi SI, Akagi K.

Jpn J Clin Oncol. 2017 Jun 1;47(6):576-580. doi: 10.1093/jjco/hyx023.


Modulation of transcription factor binding and epigenetic regulation of the MLH1 CpG island and shore by polymorphism rs1800734 in colorectal cancer.

Savio AJ, Bapat B.

Epigenetics. 2017 Jun 3;12(6):441-448. doi: 10.1080/15592294.2017.1305527. Epub 2017 Mar 17.


Expression and promoter DNA methylation of MLH1 in colorectal cancer and lung cancer.

Ma Y, Chen Y, Petersen I.

Pathol Res Pract. 2017 Apr;213(4):333-338. doi: 10.1016/j.prp.2017.01.014. Epub 2017 Jan 22.


Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.

Jia P, Chastain M, Zou Y, Her C, Chai W.

Nucleic Acids Res. 2017 Feb 17;45(3):1219-1232. doi: 10.1093/nar/gkw1170.


Autophagy influences the low-dose hyper-radiosensitivity of human lung adenocarcinoma cells by regulating MLH1.

Wang Q, Xiao Z, Lin Z, Zhou J, Chen W, Jie W, Cao X, Yin Z, Cheng J.

Int J Radiat Biol. 2017 Jun;93(6):600-606. doi: 10.1080/09553002.2017.1286052. Epub 2017 Feb 13.


Molecular analysis of MLH1 variants in Chinese sporadic colorectal cancer patients.

Peng HX, Xu X, Yang R, Chu YM, Yang DM, Xu Y, Zhou FL, Ma WZ, Zhang XJ, Guan M, Yang ZH, Jin ZD.

Genet Mol Res. 2016 Apr 26;15(2). doi: 10.4238/gmr.15027689.


Polymorphisms of Selected DNA Repair Genes and Lung Cancer in Chromium Exposure.

Halasova E, Matakova T, Skerenova M, Krutakova M, Slovakova P, Dzian A, Javorkova S, Pec M, Kypusova K, Hamzik J.

Adv Exp Med Biol. 2016;911:17-22. doi: 10.1007/5584_2016_218.


In vitro study of human mutL homolog 1 hypermethylation in inducing drug resistance of esophageal carcinoma.

Cao Y, Chen Y, Huang Y, Liu Z, Li G.

Ir J Med Sci. 2017 May;186(2):257-263. doi: 10.1007/s11845-016-1401-2. Epub 2016 Jan 18.


Exonic Splicing Mutations Are More Prevalent than Currently Estimated and Can Be Predicted by Using In Silico Tools.

Soukarieh O, Gaildrat P, Hamieh M, Drouet A, Baert-Desurmont S, Fr├ębourg T, Tosi M, Martins A.

PLoS Genet. 2016 Jan 13;12(1):e1005756. doi: 10.1371/journal.pgen.1005756. eCollection 2016 Jan. Erratum in: PLoS Genet. 2016 Apr;12(4):e1005971.


Polymorphisms in mismatch repair genes are associated with risk and microsatellite instability of gastric cancer, and interact with life exposures.

Zhu H, Li X, Zhang X, Chen D, Li D, Ren J, Gu H, Shu Y, Wang D.

Gene. 2016 Mar 15;579(1):52-7. doi: 10.1016/j.gene.2015.12.050. Epub 2015 Dec 24.


Reappraisal of hMLH1 promoter methylation and protein expression status in the serrated neoplasia pathway.

Lee EJ, Chun SM, Kim MJ, Jang SJ, Kim do S, Lee DH, Youk EG.

Histopathology. 2016 Aug;69(2):198-210. doi: 10.1111/his.12925. Epub 2016 Feb 28.


Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors.

Levine AJ, Phipps AI, Baron JA, Buchanan DD, Ahnen DJ, Cohen SA, Lindor NM, Newcomb PA, Rosty C, Haile RW, Laird PW, Weisenberger DJ.

Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):68-75. doi: 10.1158/1055-9965.EPI-15-0935. Epub 2015 Oct 28.


The hMLH1 -93G>A Polymorphism and Risk of Ovarian Cancer in the Chinese Population.

Niu L, Li S, Liang H, Li H.

PLoS One. 2015 Aug 14;10(8):e0135822. doi: 10.1371/journal.pone.0135822. eCollection 2015.


Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.

Wu H, Zeng H, Lam R, Tempel W, Kerr ID, Min J.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):981-5. doi: 10.1107/S2053230X15010183. Epub 2015 Jul 28.


DNA methylation of hMLH1 correlates with the clinical response to cisplatin after a surgical resection in Non-small cell lung cancer.

Wu F, Lu M, Qu L, Li DQ, Hu CH.

Int J Clin Exp Pathol. 2015 May 1;8(5):5457-63. eCollection 2015.


Segregation of a novel MLH1 mutation in an Iranian Lynch syndrome family.

Ghafouri-Fard S, Fardaei M, Lankarani KB, Miryounesi M.

Gene. 2015 Oct 10;570(2):304-5. doi: 10.1016/j.gene.2015.07.005. Epub 2015 Jul 3.


Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer.

Shigeyasu K, Nagasaka T, Mori Y, Yokomichi N, Kawai T, Fuji T, Kimura K, Umeda Y, Kagawa S, Goel A, Fujiwara T.

PLoS One. 2015 Jun 29;10(6):e0130409. doi: 10.1371/journal.pone.0130409. eCollection 2015.


Lynch syndrome caused by MLH1 mutations is associated with an increased risk of breast cancer: a cohort study.

Harkness EF, Barrow E, Newton K, Green K, Clancy T, Lalloo F, Hill J, Evans DG.

J Med Genet. 2015 Aug;52(8):553-6. doi: 10.1136/jmedgenet-2015-103216. Epub 2015 Jun 22.


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