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Items: 18


Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors.

Adibekian A, Martin BR, Wang C, Hsu KL, Bachovchin DA, Niessen S, Hoover H, Cravatt BF.

Nat Chem Biol. 2011 May 15;7(7):469-78. doi: 10.1038/nchembio.579. Erratum in: Nat Chem Biol. 2012 Mar;8(3):318.


Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.

Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF.

J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. doi: 10.1124/jpet.111.180257.


The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission.

Tanimura A, Yamazaki M, Hashimotodani Y, Uchigashima M, Kawata S, Abe M, Kita Y, Hashimoto K, Shimizu T, Watanabe M, Sakimura K, Kano M.

Neuron. 2010 Feb 11;65(3):320-7. doi: 10.1016/j.neuron.2010.01.021.


Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice.

Gao Y, Vasilyev DV, Goncalves MB, Howell FV, Hobbs C, Reisenberg M, Shen R, Zhang MY, Strassle BW, Lu P, Mark L, Piesla MJ, Deng K, Kouranova EV, Ring RH, Whiteside GT, Bates B, Walsh FS, Williams G, Pangalos MN, Samad TA, Doherty P.

J Neurosci. 2010 Feb 10;30(6):2017-24. doi: 10.1523/JNEUROSCI.5693-09.2010.


Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.

Hoover HS, Blankman JL, Niessen S, Cravatt BF.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5838-41. doi: 10.1016/j.bmcl.2008.06.091.


Targeting the endocannabinoid system: to enhance or reduce?

Di Marzo V.

Nat Rev Drug Discov. 2008 May;7(5):438-55. doi: 10.1038/nrd2553. Review.


Enzymatic pathways that regulate endocannabinoid signaling in the nervous system.

Ahn K, McKinney MK, Cravatt BF.

Chem Rev. 2008 May;108(5):1687-707. doi: 10.1021/cr0782067. Review. No abstract available.


Endocannabinoid-mediated synaptic plasticity in the CNS.

Chevaleyre V, Takahashi KA, Castillo PE.

Annu Rev Neurosci. 2006;29:37-76. Review.


A streamlined platform for high-content functional proteomics of primary human specimens.

Jessani N, Niessen S, Wei BQ, Nicolau M, Humphrey M, Ji Y, Han W, Noh DY, Yates JR 3rd, Jeffrey SS, Cravatt BF.

Nat Methods. 2005 Sep;2(9):691-7.


Profiling enzyme activities in vivo using click chemistry methods.

Speers AE, Cravatt BF.

Chem Biol. 2004 Apr;11(4):535-46.


Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain.

Bisogno T, Howell F, Williams G, Minassi A, Cascio MG, Ligresti A, Matias I, Schiano-Moriello A, Paul P, Williams EJ, Gangadharan U, Hobbs C, Di Marzo V, Doherty P.

J Cell Biol. 2003 Nov 10;163(3):463-8.


Discovering potent and selective reversible inhibitors of enzymes in complex proteomes.

Leung D, Hardouin C, Boger DL, Cravatt BF.

Nat Biotechnol. 2003 Jun;21(6):687-91.


Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness.

Jessani N, Liu Y, Humphrey M, Cravatt BF.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10335-40.


Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics.

Ong SE, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, Pandey A, Mann M.

Mol Cell Proteomics. 2002 May;1(5):376-86.


An automated multidimensional protein identification technology for shotgun proteomics.

Wolters DA, Washburn MP, Yates JR 3rd.

Anal Chem. 2001 Dec 1;73(23):5683-90.


Large-scale analysis of the yeast proteome by multidimensional protein identification technology.

Washburn MP, Wolters D, Yates JR 3rd.

Nat Biotechnol. 2001 Mar;19(3):242-7.


Activity-based protein profiling: the serine hydrolases.

Liu Y, Patricelli MP, Cravatt BF.

Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14694-9.

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