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Items: 1 to 20 of 31

1.

Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.

Leonard E, Ajikumar PK, Thayer K, Xiao WH, Mo JD, Tidor B, Stephanopoulos G, Prather KL.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13654-9. doi: 10.1073/pnas.1006138107. Epub 2010 Jul 19.

2.

Cytochrome P450 oxygenases of Taxol biosynthesis.

Kaspera R, Croteau R.

Phytochem Rev. 2006 Jun;5(2-3):433-444.

3.

Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering.

Morrone D, Lowry L, Determan MK, Hershey DM, Xu M, Peters RJ.

Appl Microbiol Biotechnol. 2010 Feb;85(6):1893-906. doi: 10.1007/s00253-009-2219-x. Epub 2009 Sep 24.

4.

Programming cells by multiplex genome engineering and accelerated evolution.

Wang HH, Isaacs FJ, Carr PA, Sun ZZ, Xu G, Forest CR, Church GM.

Nature. 2009 Aug 13;460(7257):894-898. doi: 10.1038/nature08187. Epub 2009 Jul 26.

5.

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production.

Engels B, Dahm P, Jennewein S.

Metab Eng. 2008 May-Jul;10(3-4):201-6. doi: 10.1016/j.ymben.2008.03.001. Epub 2008 Mar 26.

PMID:
18485776
6.

Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms.

Ajikumar PK, Tyo K, Carlsen S, Mucha O, Phon TH, Stephanopoulos G.

Mol Pharm. 2008 Mar-Apr;5(2):167-90. doi: 10.1021/mp700151b. Epub 2008 Mar 21. Review.

PMID:
18355030
7.

CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the cyclic ether 5(12)-oxa-3(11)-cyclotaxane.

Rontein D, Onillon S, Herbette G, Lesot A, Werck-Reichhart D, Sallaud C, Tissier A.

J Biol Chem. 2008 Mar 7;283(10):6067-75. doi: 10.1074/jbc.M708950200. Epub 2007 Dec 31.

8.

Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli.

Leonard E, Koffas MA.

Appl Environ Microbiol. 2007 Nov;73(22):7246-51. Epub 2007 Sep 28.

9.

Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene.

Klein-Marcuschamer D, Ajikumar PK, Stephanopoulos G.

Trends Biotechnol. 2007 Sep;25(9):417-24. Epub 2007 Aug 2. Review.

PMID:
17681626
10.

Production and engineering of terpenoids in plant cell culture.

Roberts SC.

Nat Chem Biol. 2007 Jul;3(7):387-95. Review.

PMID:
17576426
11.

Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli.

Jin YS, Stephanopoulos G.

Metab Eng. 2007 Jul;9(4):337-47. Epub 2007 Apr 12.

PMID:
17509919
12.

Expanding the metabolic engineering toolbox: more options to engineer cells.

Tyo KE, Alper HS, Stephanopoulos GN.

Trends Biotechnol. 2007 Mar;25(3):132-7. Epub 2007 Jan 24. Review.

PMID:
17254656
13.

The shape of things to come: structural and synthetic studies of taxol and related compounds.

Kingston DG.

Phytochemistry. 2007 Jul;68(14):1844-54. Epub 2006 Dec 20. Review.

14.

Taxanes: perspectives for biotechnological production.

Frense D.

Appl Microbiol Biotechnol. 2007 Jan;73(6):1233-40. Epub 2006 Nov 24. Review.

PMID:
17124581
15.

Production of isoprenoid pharmaceuticals by engineered microbes.

Chang MC, Keasling JD.

Nat Chem Biol. 2006 Dec;2(12):674-81.

PMID:
17108985
16.

Chromosomal promoter replacement of the isoprenoid pathway for enhancing carotenoid production in E. coli.

Yuan LZ, Rouvière PE, Larossa RA, Suh W.

Metab Eng. 2006 Jan;8(1):79-90. Epub 2005 Oct 28.

PMID:
16257556
17.

Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae.

Dejong JM, Liu Y, Bollon AP, Long RM, Jennewein S, Williams D, Croteau RB.

Biotechnol Bioeng. 2006 Feb 5;93(2):212-24.

PMID:
16161138
18.

Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets.

Alper H, Miyaoku K, Stephanopoulos G.

Nat Biotechnol. 2005 May;23(5):612-6. Epub 2005 Apr 10.

PMID:
15821729
19.

Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesis.

Jennewein S, Park H, DeJong JM, Long RM, Bollon AP, Croteau RB.

Biotechnol Bioeng. 2005 Mar 5;89(5):588-98.

PMID:
15672381
20.

Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis.

Jennewein S, Wildung MR, Chau M, Walker K, Croteau R.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9149-54. Epub 2004 Jun 3.

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