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Prostaglandins Other Lipid Mediat. 1998 Aug;56(5-6):341-61.

The advent of highly selective inhibitors of cyclooxygenase--a review.

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1
Medical Service, Dallas VA Medical Center, TX 75216, USA. bcryer@mednet.swmed.edu

Abstract

Cyclooxygenase (COX) exists in two isoforms, COX-1 and COX-2, COX-1 is present and is constitutively expressed in most cells and tissues, whereas COX-2 is felt to principally mediate inflammation. However, this distinction appears to be challenged by recent observations. This review addresses the roles of COX-1 and COX-2 isoforms in physiologic and pathophysiologic states and reviews potential therapeutic roles for selective COX inhibitors.

PMID:
9990677
[Indexed for MEDLINE]
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