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Am J Psychiatry. 1999 Feb;156(2):315-6.

Prevalence of depressive symptoms early in the course of schizophrenia.

Author information

1
Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa College of Medicine, Iowa City 52242, USA. thomas-wassink@uiowa.edu

Abstract

OBJECTIVE:

The rate of depressive symptoms early in the course of schizophrenia was determined.

METHOD:

Seventy subjects with recent-onset schizophrenia were followed for 5 years by using semistructured interview instruments. The initial assessment included ratings of each criterion A symptom of a DSM-III-R major depressive episode. The rates of symptoms experienced with at least moderate severity were calculated, and an algorithm based on DSM identified subjects meeting the criteria for a major depressive episode.

RESULTS:

Four symptoms were present to at least a moderate degree in a majority of subjects, while no symptom was present in fewer than 12% of subjects. More than one-third of the subjects met the algorithmic criteria for a major depressive episode at the time of intake.

CONCLUSIONS:

Depressive symptoms are common early in the course of schizophrenia. This finding is consistent with other recent data and has potential implications for current diagnostic and treatment practices.

PMID:
9989572
DOI:
10.1176/ajp.156.2.315
[Indexed for MEDLINE]

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