Format

Send to

Choose Destination
See comment in PubMed Commons below
J Hered. 1999 Jan-Feb;90(1):112-8.

A review of canine inherited bleeding disorders: biochemical and molecular strategies for disease characterization and carrier detection.

Author information

1
Comparative Coagulation Section, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. mbb9@cornell.edu

Abstract

Many different inherited bleeding disorders have been identified in dogs, defined on the basis of quantitative, functional, or structural defects in specific hemostatic proteins or pathways. Most of these disorders are caused by single-gene defects and biochemical assays provide an accurate measure of disease phenotype. Phenotypic disease classifications, however, are often genetically heterogeneous. Protein-based carrier detection assays are fast, inexpensive, and do not require specific identification of causative mutations. The limitations of these tests arise from variable "overlap" regions between carrier and clear dogs, influencing positive and negative predictive values of carrier detection tests within breed populations. Molecular diagnostic techniques enhance the accuracy of carrier detection, providing their clinical application takes into account the molecular heterogeneity underlying naturally occurring hemostatic defects in dogs.

PMID:
9987916
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center