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Vaccine. 1999 Jan;17(2):114-7.

For discussion: live attenuated vaccines for group B meningococcus.

Author information

1
University Department of Paediatrics, John Radcliffe Hospital, Oxford, UK. christoph.tang@paediatrics.oxford.ac.uk

Abstract

Current attempts at preventing infections caused by group B Neisseria meningitidis are largely directed on generating immune responses to outer membrane proteins or the lipopolysaccharide of this organism. We suggest an alternative approach: the use of a live, attenuated strain of Neisseria meningitidis which could be delivered mucosally to elicit both local and systemic immune responses.

PMID:
9987144
DOI:
10.1016/s0264-410x(98)00163-7
[Indexed for MEDLINE]

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