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Mosaic organization of DNA nucleotides.

Author information

1
Department of Physics, Boston University, Massachusetts 02215, USA.
2
Harvard Med Sch, Boston, MA

Abstract

Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structure ("patchiness") of DNA. We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms--one without and one with long-range power-law correlations. Although both types of sequences are highly heterogenous, they are quantitatively distinguishable by an alternative fluctuation analysis method that differentiates local patchiness from long-range correlations. Application of this analysis to selected DNA sequences demonstrates that patchiness is not sufficient to account for long-range correlation properties.

PMID:
9961383
[Indexed for MEDLINE]

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