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Med Oncol. 1998 Dec;15(4):279-81.

Combined radiation and chemotherapy in posttransplant lymphoproliferative disorder.

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Hematology-Oncology Division, University of Pennsylvania Medical Center, Philadelphia 19104, USA.


The optimal treatment for posttransplant lymphoproliferative disorder which has progressed despite a reduction in immunosuppression has not been defined. We report on two patients with stage I posttransplant lymphoproliferative disorder who developed progressive disease despite a reduction in the level of immunosuppression. Both patients were treated with combined short course CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy followed by involved-field radiation therapy. In both patients, a rapid response was obtained followed by complete remission. Combined modality therapy can be utilized successfully in progressive limited stage posttransplant lymphoproliferative disorder.

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