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Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Sep-Oct;48(5):846-54.

[The cytochemical indices of the sensorimotor cortex neurons in rats differing in their trainability in a food-acquiring habit].

[Article in Russian]

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Brain Research Institute, Russian Academy of Medical Sciences, Moscow.


Comparative study of protein metabolism in neurons of layers III and V of the sensorimotor cortex was carried out in two groups of Wistar rats, which differed in learning results: "bad" (60% of population) and "good" learners (40%). It was found out that the associative neurons (layer III) were most sensitive to cognitive load. In "bad" learners, an increase in nuclear and cytoplasmic dimensions and rise in protein concentration and content took place in these neurons, while in the efferent neurons (layer V) the protein content increased only in the cytoplasm. In "good" learners, the cognitive load led to a decrease in all the cytochemical parameters in neurons of the layer III while in the neurons of the layer V the content and concentration of proteins increased both in nuclei and cytoplasm. It is suggested that the character of protein metabolism changes produced by information load can be considered as a reflection of individual peculiarities of cognitive activity, and the extent of cytochemical changes as a reflection of complicity of a cognitive task.

[Indexed for MEDLINE]

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