Format

Send to

Choose Destination
Bioorg Med Chem Lett. 1998 Dec 15;8(24):3637-42.

Design and synthesis of novel conformationally restricted HIV protease inhibitors.

Author information

1
Vertex Pharmaceuticals Incorporated, Cambridge, MA 02139, USA.

Abstract

A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent protease inhibitors. Thus, probe compounds 3-7 were designed, synthesized, and found to be potent inhibitors of HIV protease.

PMID:
9934485
DOI:
10.1016/s0960-894x(98)00670-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center